Inclusion Criteria:

          1. Histologically proven unilateral or bilateral primary breast carcinoma. (In case of
             bilateral cancer, the investigator has to decide prospectively which side will be
             evaluated for the primary endpoint.)

          2. Tumor size is clinically at least 1 cm in greatest diameter (palpable or by imaging)
             and/or with involved lymph node. In case of inflammatory disease, the extent of
             inflammation may be the measurable lesion.

          3. Documentation of inflammatory breast cancer

          4. Woman age > or = 18

          5. Performance status of 0-2 by Eastern Cooperative Oncology Group (ECOG) criteria

          6. Known HER2 status

          7. Normal cardiac function must be documented within 90 days prior to registration either
             via an ECHO or MUGA or per physician's review of symptoms and medical history. If an
             ECHO is performed as standard of care, the ejection fraction must be above the normal
             limit of the institution.. If not available in the medical chart, the ECHOs or MUGAs
             are not required to be repeated for research purposes.

             a. Date of Echo or multigated acquisition (MUGA) (within 90 days) if performed

          8. Staging work-up prior to registration

               1. Date of physical examination (within 90 days)

               2. Date of bilateral mammogram (within 90 days)

               3. Date of breast ultrasound (within 90 days)

               4. Date of MRI breast (within 30 days)

               5. Chest X-ray or CT- Chest or CT/PET Scan that includes the Chest may be done at
                  physician's discretion (within 90 days). If not available in the medical chart,
                  the Chest X-ray or CT- Chest or CT/PET Scan that includes the Chest is not
                  required to be repeated for research purposes.

               6. Other tests as clinically indicated

          9. Laboratory requirements:

               1. Hematology:

                    -  Absolute Neutrophil Count (ANC) ≥ 1,500/μl

                    -  Platelets ≥ 100,000/μl

               2. Hepatic Function

                    -  Total Bilirubin <1x upper limit of normal (ULN)

                    -  aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2x ULN

               3. Renal Function

                  - Creatinine <1.5x ULN

               4. Proteinuria

                  - Random urine total protein <100mg/dL. Urine Protein Creatinine (UPC) ratio <2g

               5. Negative pregnancy test for women of childbearing potential within 14 days prior
                  to registration.

         10. All patients must be informed of the investigational nature of this study and must
             sign and give written informed consent in accordance with institutional and federal
             guidelines.

             Exclusion Criteria:

         11. Evidence of distant metastasis. If radiographic suspicion of distant metastatic site,
             a negative biopsy must be available in the medical record. If not available in the
             medical record, the subject may be included and a confirmatory biopsy is not required
             to be performed for research purposes.

         12. Known or suspected congestive heart failure, angina pectoris requiring antianginal
             medication, or other clinically significant cardiac condition.

         13. Pregnant or nursing women may not participate due to the possibility of harm to fetus
             or nursing infants from this treatment regimen. Women of childbearing potential may
             not participate unless they have agreed to use an adequate contraceptive method
             throughout study treatment and for one month after completion of treatment.

         14. Male patients

         15. Pre-existing peripheral neuropathy of severity grade ≥ 2 (limiting instrumental
             activities of daily living).

         16. Incomplete wound healing.

         17. Active and significant bleeding

         18. Known allergy, hypersensitivity or prior infusion reaction to one or more of the
             therapies incorporated into this treatment protocol.

         19. Bone marrow depression or hematologic parameters in the range that would increase the
             risk for severe bleeding.