Inclusion Criteria:

          1. Is male or female, aged 18 years or older at the time of consent; preferably
             non-Asian.

          2. Has histologically or cytologically confirmed metastatic, or unresectable locally
             advanced, recurrent NSCLC.

          3. Has at least one measurable disease by computed tomography (CT) or magnetic resonance
             imaging (MRI), according to Response Evaluation Criteria in Solid Tumors (RECIST)
             Version 1.1.

          4. Has documented evidence of an activating EGFR mutation in the tumor tissue determined
             by either sequencing or PCR-based technique (Part 1).

          5. For Part 1 only: subjects with a positive T790M mutation are preferred, but not
             required. Confirmation of T790M mutation status will be determined from an archived
             tumor tissue sample or fresh tumor tissue sample obtained via biopsy if archived
             tissue is not available. In Part 2, subjects must have a confirmed, positive T790M
             EGFR mutation (acquired T790M EGFR mutation or "de novo" T790M EGFR mutation).

          6. Has a life expectancy of at least 3 months.

          7. Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

          8. Has adequate hematological and physiological functions.

          9. Has documented disease progression while receiving at least 30 days of treatment with
             a currently approved EGFR tyrosine kinase inhibitor (TKI) (e.g., erlotinib, gefitinib
             or afatinib) with intervening treatment after most recent EGFR TKI therapy (not
             required for "de novo" T790M EGFR mutation).

         10. Signed and dated written informed consent obtained prior to any study-specific
             evaluation.

        Exclusion Criteria:

          1. Has a history of interstitial lung disease related to prior EGFR inhibitor therapy.

          2. Has an EGFR TKI- related toxicity that has NOT resolved to Grade 1 or less.

          3. Is test positive for hepatitis C virus (HCV), hepatitis B virus (HBV) or human
             immunodeficiency virus (HIV) antibody.

          4. Has received the prohibited therapy (e.g., concurrent anti-cancer therapy including
             but not limited to: chemotherapy, radiation, hormonal, or immunotherapy) ≤14 days
             prior to first planned dose of AC0010MA.

          5. Received prior treatment with AZD9291 (osimertinib) or CO1686 (rociletinib) and
             experienced disease progression.

          6. Is a female subject who is pregnant or breastfeeding.

          7. Female subjects (if of child bearing potential) and male subjects (with a partner of
             child bearing potential) must use medically acceptable methods of birth control before
             study entry, for the duration of the study, and for at least 6 months after the last
             intake of study drug.

          8. Has a serious or unstable concomitant systemic disorder incompatible with the clinical
             study (e.g., substance abuse, uncontrolled psychiatric condition, uncontrolled
             intercurrent illness including active infection, arterial thrombosis, or symptomatic
             pulmonary embolism).

          9. Has any other reason(s) for the investigator to consider that the subject should not
             participate in the study.

         10. Is receiving treatment with medication(s) that are known to be strong inhibitors or
             inducers of CYP3A4/5.