Inclusion Criteria:

          1. Provision of fully informed consent prior to any study specific procedures.

          2. Patients must be ≥20 years of age.

          3. RET fusion positive,FGFR amplification, Refractory Solid Tumors that has recurred or
             progressed following standard therapy, or that has not responded to standard therapy,
             or for which there is no standard therapy.

          4. ECOG performance status 0-2.

          5. Have measurable or evaluated disease based on RECIST1.1. as determined by
             investigator.

          6. Adequate Organ Function Laboratory Values

               -  Absolute neutrophil count ≥ 1.5 x 109/L, Hemoglobin ≥ 9g/dL, Platelets ≥ 75 x
                  109/L

               -  bilirubin ≤ 1.5 x upper limit of normal AST/ALT ≤ 2.5 x upper limit of normal
                  (5.0 X upper limit of normal , for subjects with liver metastases)

               -  creatinine ≤1.5 x UNL

          7. Patients of child-bearing potential should be using adequate contraceptive measures
             (two forms of highly reliable methods) should not be breast feeding and must have a
             negative pregnancy test prior to start of dosing.

          8. Adequate heart function.

        Exclusion Criteria:

          1. Patients with second primary cancer, except: adequately treated non-melanoma skin
             cancer, curatively treated in-situ cancer of the cervix, or other solid tumours
             curatively treated with no evidence of disease for ≤5 years.

          2. Has known active central nervous system (CNS) metastases.

          3. Has an active infection requiring systemic therapy.

          4. Pregnancy or breast feeding

          5. Patients with cardiac problem.

          6. Any previous treatment with sunitinib