AZD5363 is a highly potent adenosine triphosphate (ATP)-competitive AKT inhibitor with
IC50<10nmol/l for all three AKT isoforms.
AZD5363 is well designed to inhibit the important main signal pathway in various human
cancer. AZD5363 is a specific inhibitor of the AKT pathway which is activated in a wide
spectrum of tumours.The combination of AZD5363 to standard chemotherapy, paclitaxel, might
improve the outcomes of 2nd line therapy in advanced gastric cancer patients .
Inclusion Criteria:
1. Provision of fully informed consent prior to any study specific procedures.
2. Patients must be ≥20 years of age.
3. Advanced gastric adenocarcinoma (including GEJ) that has progressed during or after
first-line therapy.
- The 1st line regimen must have contained doublet 5-fluoropyrimidine and platinum
based regimen.
- Relapse within 6 months of completion of adjuvant/neoadjuvant chemotherapy
containing doublet 5-fluoropyrimidine and platinum-based regimen could be
considered as 1st line therapy.
4. Previous adjuvant/neoadjuvant chemotherapy is allowed, if completed more than 6 months
prior to starting the 1st line therapy.
5. Provision of tumor sample (from either a resection or biopsy)
6. Patients with PIK3CA mutation and/or PIK3CA amplification
7. Eastern Cooperative Oncology Group performance status 0-1.
8. Patients must have a life expectancy ≥ 3 months from proposed first dose date.
9. Patients must have acceptable bone marrow, liver and renal function measured within 28
days prior to administration of study treatment as defined below:
- Haemoglobin ≥9.0 g/dL (transfusion allowed)
- Absolute neutrophil count (ANC) ≥ 1.5 x 109/L
- White blood cells (WBC) > 3 x 109/L
- Platelet count ≥100 x 109/L (transfusion allowed)
- Total bilirubin ≤ 1.5 x institutional upper limit of normal (ULN)
- AST (SGOT)/ALT (SGPT) ≤ 2.5 x institutional upper limit of normal unless liver
metastases are present in which case it must be ≤ 5x ULN
- Serum creatinine ≤1.5 x institutional ULN
10. At least one measurable lesion that can be accurately assessed by imaging or physical
examination at baseline and following up visits.
11. Negative urine or serum pregnancy test within 28 days of study treatment, confirmed
prior to treatment on day 1.
Patients of child-bearing potential should be using adequate contraceptive measures
(two forms of highly reliable methods) should not be breast feeding and must have a
negative pregnancy test prior to start of dosing.
12. Patients are willing and able to comply with the protocol for the duration of the
study including undergoing treatment and scheduled visits and examinations.
Exclusion Criteria:
1. More than one prior chemotherapy regimen (except for adjuvant/neoadjuvant chemotherapy
with more than 6 month wash out period) for the treatment of gastric cancer in the
advanced setting.
- In case of investigator's discretion, patient has a specific biomarker and meets
all eligible criteria except for line of therapy, patient will be allowed.
However, only 3rd line is allowed in this isolated cases. In the case of other,
PI should confirm.
2. Any previous treatment with PIK3CA and/or AKT inhibitors or agents with mixed PI3K /
mTOR activity.
3. Any previous treatment with paclitaxel
4. Patients with second primary cancer, except: adequately treated non-melanoma skin
cancer, curatively treated in-situ cancer of the cervix, or other solid tumours
curatively treated with no evidence of disease for ≤5 years.
5. HER2 positive patients (defined by HER2 3+ by immunohistochemistry or HER2 SISH +)
6. Patients unable to swallow orally administered medication.
7. Any investigational drug or product administered within 30 days or 5 half-lives,
whichever is longer, of the first dose of AZD5363.
8. Patients receiving any systemic chemotherapy, radiotherapy (except for palliative
reasons), within 3 weeks from the last dose prior to study treatment (or a longer
period depending on the defined characteristics of the agents used). The patient can
receive a stable dose of bisphosphonates or denosumab for bone metastases, before and
during the study as long as these were started at least 4 weeks prior to treatment.
9. Previous major surgery within 4weeks prior to first dose.
10. With the exception of alopecia, any ongoing toxicities (>Common Toxicity Criteria for
Adverse Effects grade 1) caused by previous cancer therapy.
11. Intestinal obstruction or Common Toxicity Criteria for Adverse Effects grade 3 or
grade 4 upper GI bleeding within 4 weeks before the enrollment.
12. Resting ECG with measurable QTcB > 480 msec on 2 or more time points within a 24 hour
period or family history of long QT syndrome.
13. Patients with cardiac problem as follows: uncontrolled hypertension (BP ≥150/95 mmHg
despite medical therapy) Left ventricular ejection fraction <55% measured by
echocardiography, Atrial fibrillation with a ventricular rate >100 bpm on ECG at rest
, Symptomatic heart failure (NYHA grade II-IV), Prior or current cardiomyopathy,
Severe valvular heart disease, Uncontrolled angina (Canadian Cardiovascular Society
grade II-IV despite medical therapy), Acute coronary syndrome within 6 months prior to
starting treatment.
14. Active or untreated brain metastases or spinal cord compression Patients with treated
brain metastases or spinal cord compression are eligible if they have minimal
neurologic symptoms, evidence of stable disease (for at least 1 month) or response on
follow-up scan, and require no corticosteroid therapy for ≥ 1 week.
15. Patients with proteinuria (3+ on dipstick analysis )
16. Female patients who are breast-feeding or child-bearing
17. Any evidence of severe or uncontrolled systemic disease, active infection, active
bleeding diatheses or renal transplant, including any patient known to have hepatitis
B, hepatitis C or human immunodeficiency virus (HIV)
18. Concomitant use of known potent CYP3A4 inhibitors such as ketoconazole, itraconazole,
ritonavir, indinavir, saquinavir, telithromycin, clarithromycin and nelfinavir.
