Inclusion Criteria:

        Patients must be ≥18 years of age

        Patients must have documented IDH1 and/or IDH2 gene-mutated disease

        Patients must have an advanced hematologic malignancy with an IDH1 and/or IDH2 mutation

        Patient must be able to understand and willing to sign an informed consent

        Patients must have ECOG PS of 0 to 2

        Patients must have adequate hepatic function as evidenced by serum total bilirubin ≤1.5
        upper limit of normal (ULN), unless considered due to Gilbert's disease or leukemic
        involvement

        Aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase
        (ALP) ≤3.0 × ULN, unless considered due to involvement by the neoplasm under consideration
        for treatment

        Patients must have adequate renal function as evidenced by a serum creatinine ≤2.0 × ULN or
        Creatinine clearance 40 mL/min based on the Cockroft-Gault glomerular filtration rate (GFR)
        estimation

        Patients must be recovered from any clinically relevant toxic effects of any prior surgery,
        radiotherapy, or other therapy intended for the treatment of cancer

        Female patients with reproductive potential must have a negative serum pregnancy test
        within 7 days prior to the start of therapy. Patients with reproductive potential are
        defined as sexually mature women who have not undergone a hysterectomy, bilateral
        oophorectomy or tubal occlusion or who have not been naturally postmenopausal (i.e., who
        have not menstruated at all) for at least 24 consecutive months (i.e., has had menses at
        any time in the preceding 24 consecutive months)

        Exclusion Criteria:

        Patients who have undergone HSCT within 60 days

        Patients who received systemic anticancer therapy or radiotherapy <14 days prior to their
        first day of study drug administration

        Patients who received an investigational agent <14 days prior

        Patients who are pregnant or breast feeding

        Patients with an active severe infection who require anti-infective therapy or with an
        unexplained fever >38.5°C during Screening visits or on their first day of study drug
        administration (at the discretion of the Investigator, patients with tumor fever may be
        enrolled)

        Patients with New York Heart Association (NYHA) Class III or IV congestive heart failure or
        LVEF <40% by echocardiogram (ECHO) or multi-gated acquisition (MUGA) scan within
        approximately 28 days of C1D1

        Patients with a history of myocardial infarction within the last 6 months

        Patients with known unstable or uncontrolled angina pectoris

        Patients with a known history of severe and/or uncontrolled ventricular arrhythmias

        Patients with QTc interval ≥450 msec or with other factors that increase the risk of QT
        prolongation or arrhythmic events

        Patients taking medications that are known to prolong the QT interval

        Patients with known infection with human immunodeficiency virus (HIV) or active hepatitis B
        or C

        Patients with clinical symptoms suggesting active central nervous system (CNS) leukemia or
        known CNS leukemia. Evaluation of cerebrospinal fluid is only required if there is a
        clinical suspicion of CNS involvement by leukemia during Screening

        Patients with immediately life-threatening, severe complications of hematologic
        malignancies such as uncontrolled bleeding, pneumonia with hypoxia or shock, and/or
        disseminated intravascular coagulation