This is a single-arm, open-label, multicenter, phase 2 clinical trial aimed at evaluating the
efficacy and safety of the combination of bendamustine and brentuximab vedotin as a first
salvage therapy in patients with relapsed or refractory Hodgkin's lymphoma or PTCL.
A total of 25 patients with PTCL, and 40 with Hodgkin's lymphoma are expected to be treated
according to this treatment protocol.
In the study, intravenous bendamustine will be administered at a dose of 90 mg/m2 on day 1
and 2 and brentuximab will be given intravenously at a total dose of 1.8 mg/kg on day 1 of
each 21 days-based cycle, for 6 cycles. All patients achieving a CR can be considered
eligible to peripheral blood stem cell mobilization (to be performed with granulocytecolony
stimulating factor alone) and may proceed to an ASCT at any time after cycle 4.
Inclusion criteria for patients with classical Hodgkin's lymphoma:
1. Patients with primary refractory disease after one previous line of therapy or at
first relapse after one previous line of therapy. Patients must have completed any
prior treatment with radiation, chemotherapy, biologics, immunotherapy and/or other
investigational agents at least 4 weeks prior to the first BBV dose
2. Histologically-confirmed CD30+ disease (IHC BerH2 antibody)
3. Age from 18 to 60 years.
4. Fluorodeoxyglucose (FDG)-avid and measurable disease (lymph nodes must have long axis
of 1.5 cm regardless of short axis or long axis 1.1 to 1.5 and short axis > 1.0 cm) as
documented by both PET and CT.
5. An Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
6. The following required baseline laboratory data: absolute neutrophil count (ANC) ≥
1500/μL, unless known marrow involvement due to disease, platelets ≥ 75,000/μL, unless
known marrow involvement due to disease, bilirubin ≤ 1.5 x upper limit of normal (ULN)
or ≤ 3 x ULN for patients with Gilbert's disease, serum creatinine ≤ 1.5 X ULN,
alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 X ULN.
7. Serum Albumin ≥ 3 g/dL.
8. Females of childbearing potential must have a negative serum or urine β-hCG pregnancy
test result within 7 days prior to the first dose of therapy. Females of
non-childbearing potential are those who are postmenopausal for more than 1 year or
who have had a bilateral tubal ligation or hysterectomy.
9. Both females of childbearing potential and males who have partners of childbearing
potential must agree to use an effective contraceptive method during the study and for
at least 6 months following the last dose of study drug.
10. Male patients, even if surgically sterilized (i.e., post vasectomy), who:
1. Agree to practice effective barrier contraception during the entire study
treatment period and through 6 months after the last dose of the study drug, or
2. Agree to completely abstain from heterosexual intercourse.
11. Patients must provide written informed consent
Exclusion criteria for patients with classical Hodgkin's lymphoma:
1. Previous treatment with bendamustine or brentuximab vedotin.
2. Prior autologous stem cell transplant.
3. Known history of any of the following cardiovascular conditions: myocardial infarction
within 2 years of study entry; NYHA class III or IV heart failure; cardiac
arrhythmias; angina; any electrocardiographic evidence of acute ischemia or conduction
system abnormalities; recent evidence (within 6 months before the first dose of study
drug) of a left-ventricular ejection fraction < 50%.
4. History of another primary malignancy for within 3 years of study entry (the following
are exempt from the 3-year limit: non-melanoma skin cancer, curatively treated
localized prostate cancer and cervical carcinoma in situ on biopsy or a squamous
intraepithelial lesion on PAP smear).
5. Known cerebral/meningeal disease (HL or any other etiology) or testicular involvement.
6. Signs or symptoms of progressive multifocal leukoencephalopathy (PML).
7. Pre-existing Peripheral Neuropathy ≥ 2.
8. Any active systemic viral, bacterial, or fungal infection requiring treatment with
antimicrobial therapy within 2 weeks prior to the first dose of therapy.
9. Current therapy with other systemic anti-neoplastic or investigational agents.
10. Therapy with corticosteroids at greater than or equal to 20 mg/day prednisone
equivalent within 1 week prior to the first dose of therapy.
11. Women who are pregnant or breastfeeding.
12. Patients with a known hypersensitivity to recombinant proteins, murine proteins, or
any excipient contained in the drug formulation of brentuximab vedotin and to
bendamustine.
13. HIV positive.
14. HCV positive.
15. HBsAg positive; HBsAg negative patients with anti-HBcAg positive can be enrolled if
HBV DNA is negative and antiviral treatment with Lamivudine or Tenofir is provided.
16. Active varicella zoster virus (VZV) infection; previously infected patients is
accepted only with concomitant treatment with Valacyclovir or Acyclovir.
17. Patients with dementia or altered mental state that would preclude the understanding
and rendering of informed consent.
Inclusion criteria for patients with peripheral T-cell lymphomas:
1. Patients with refractory or relapsed PTCL regardless of the number of prior therapy
lines. Patients must have completed any prior treatment with radiation, chemotherapy,
biologics, immunotherapy and/or other investigational agents at least 4 weeks prior to
the first dose of therapy.
2. Signed written informed consent.
3. Age from 18 to 60 years.
4. Histologically confirmed diagnosis of PTCL, i.e. PTCL-not otherwise specified
(PTCL-NOS), angioimmunoblastic T cell lymphoma (AITL) and transformed mycosis
fungoides according to the World Health Organization (WHO) 2008 classification.
5. Histologically confirmed CD30+ PTCL (IHC BerH2 antibody).
6. Eastern Cooperative Oncology Group (ECOG) performance status score of ≤ 1 at study
entry.
7. At least one site of measurable disease in two dimensions by computed tomography. Both
nodal and extranodal sites will be taken into consideration (lymph nodes must have
long axis of 1.5 cm regardless of short axis or long axis 1.1 to 1.5 cm and short axis
> 1.0 cm).
8. Hematology values within the following limits:
1. absolute neutrophil count (ANC) ≥ 1500/mm3 independent of growth factor support;
2. platelets ≥ 75,000/mm3 or ≥ 50,000/mm3 if bone marrow involvement is independent
of transfusion support;
3. hemoglobin level ≥ 8 g/dL.
9. Biochemical values within the following limits:
1. alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 3 x upper
limit of normal (ULN);
2. total bilirubin < 1.5 x ULN (unless bilirubin rise is due to Gilbert's syndrome
or has a non-hepatic origin);
3. serum creatinine ≤ 2 x ULN;
4. serum albumin ≥ 3 g/dL.
10. Women of childbearing potential must have a negative pregnancy test within 7 days of
receiving study medication and must agree to use effective contraception, defined as:
oral contraceptives, double barrier method or practice true abstinence from sexual
intercourse during the study and for at least 6 months after the last dose of study
drug.
11. Male subjects and their female partners of childbearing potential must be willing to
use an appropriate method of contraception or practice true abstinence from sexual
intercourse during the study and for at least 6 months after the last dose of study
drug.
Exclusion criteria for patients with peripheral T-cell lymphomas:
1. Diagnosis of cutaneous T-cell lymphoma, anaplastic large-cell lymphoma (ALCL), mycosis
fungoides or Sézary Syndrome.
2. Previous treatment with bendamustine or brentuximab vedotin.
3. Known hypersensitivity to recombinant proteins, murine proteins, or to any excipient
contained in the drug formulation of brentuximab vedotin and to bendamustine.
4. Any serious active disease or co-morbid medical condition (according to investigator's
decision).
5. Prior history of malignancies other than lymphoma (except for a history of a complete
resection for basal cell or squamous cell carcinoma of the skin or carcinoma in situ
of the cervix or breast) unless the subject has been free of the disease for ≥ 3
years.
6. Pre-existing peripheral neuropathy grade ≥ 2.
7. Signs or symptoms of progressive multifocal leukoencephalopathy (PML).
8. Any serious medical condition, laboratory abnormality, or psychiatric illness that
would prevent the subject from signing the informed consent form.
9. Pregnant or lactating females or men or women of childbearing potential not willing to
use an adequate method of birth control for the duration of the study or a positive
pregnancy test on day 1 before first dose of study drug.
10. Central nervous system disease (meningeal and/or brain involvement by lymphoma) or
testicular involvement.
11. History of clinically relevant liver or renal insufficiency; significant pulmonary,
gastrointestinal, endocrine, neurologic, rheumatologic, hematologic, psychiatric, or
metabolic disturbances.
12. Known history of any of the following cardiovascular conditions: myocardial infarction
within 2 years of study entry; NYHA class III or IV heart failure; cardiac
arrhythmias; angina; any electrocardiographic evidence of acute ischemia or conduction
system abnormalities; recent evidence (within 6 months before the first dose of study
drug) of a left-ventricular ejection fraction < 50%.
13. Active systemic, viral, bacterial, or fungal infection requiring systemic antibiotics
within 2 weeks prior to first dose of study drug.
14. HIV positive.
15. HCV positive.
16. HBsAg positive; HBsAg negative patients with anti-HBcAg positive can be enrolled if
HBV DNA is negative and antiviral treatment with Lamivudine or Tenofir is provided.
17. Active varicella zoster virus (VZV) infection; previously infected patients is
accepted only with concomitant treatment with Valacyclovir or Acyclovir.
18. Prior allogeneic stem cell transplant
19. Patients with dementia or altered mental state that would preclude the understanding
and rendering of informed consent.
