Inclusion Criteria:

          1. Female patients, age ≥20 years

          2. Histologically confirmed invasive ER-, PR-, and HER2-negative (triple-negative)
             adenocarcinoma of the breast

          3. Triple-negative tumors are defined as:

             i. For HER2-negative: Fluorescence in situ hybridization (FISH)-negative (defined by
             ratio <2.0) or Immunohistochemical (IHC) 0, IHC 1+, or IHC 2+ or IHC 3+and
             FISH-negative (defined by ratio <2.0) ii. For ER- and PR-negative: < 5% tumor staining
             by immunohistochemistry (IHC)

          4. The first TNBC 20 patients with or without EGFR expression or mutation are eligible.
             Interim analysis of response rate will be calculated to determine the criteria of 21
             to 40 patients.

          5. All of the newly diagnosed TNBC patients should be met the following criteria:
             clinical node-positive with any T stage patents or clinical node-negative patients
             with cT2-4. cT1N0M0 lesions are excluded. Patients with metastatic disease are
             excluded. The measurement method of tumor size can be by physical exam and/or image
             study.

          6. Eastern Cooperative Oncology Group performance status (ECOG PS) 0-1.

          7. Within 2 weeks prior randomization:

             i. Adequate bone marrow function, hepatic function, and renal function. ii. Controlled
             blood pressure with or without antihypertensive treatment iii. Normal prothrombin time
             (PT) and partial thromboplastin time (PTT) iv. Adequate cardiac function assessed by
             12-lead ECG and if clinically indicated echocardiography to document LVEF

          8. Bilateral, synchronous breast cancer is allowed if one primary tumor meets the
             inclusion criteria.

          9. Adequate bone marrow function defined as WBC ≥3.5 x 109/L, ANC ≥1.5 x 109/L, platelets
             ≥LLN, and hemoglobin ≥10 g/dL.

         10. Adequate liver function defined as total serum bilirubin ≤1.5X ULN and serum
             transaminases ≤2.5X ULN

         11. Adequate renal function defined as creatinine ≤1.5X ULN

         12. Able and willing to give informed consent and comply with the protocol

         13. Written informed consent obtained prior to any Screening/baseline procedures

         14. Knowledge of the investigational nature of the study and ability to provide consent
             for study participation; and ability and willingness to comply with study visits,
             treatment, testing, and other study procedures

        Exclusion Criteria:

          1. ER+ (>5%) or PR+ (>5%) or Her-2 overexpression

          2. Active second malignancy during the last five years except non melanomatous skin
             cancer or carcinoma in situ of the cervix.

          3. Prior chemotherapy, radiotherapy or targeted therapy including afatinib or Her-2 or
             EGFR inhibitors.

          4. Participation in another interventional clinical trial in the preceding 30 days prior
             to trial.

          5. Patients with other concurrent severe and/or uncontrolled medical disease or infection
             which could compromise participation in the study

          6. Prior hypersensitivity reactions to a taxane or to Cremophor® EL (polyoxyethylated
             castor oil)

          7. Pregnant or breast feeding (lactating) women, where pregnancy is defined as the state
             of a female after conception and until the termination of gestation, confirmed by
             positive β-HCG laboratory test (serum > 5 mIU/mL)

          8. Women of child-bearing potential, defined as all women physiologically capable of
             becoming pregnant, unless they are using highly effective methods of contraception
             during dosing and for at least 180 days after study treatment. Highly effective
             contraception methods include:

               -  True abstinence in line with the preferred and usual lifestyle of the subject

               -  Female subject or male partner sterilization or

               -  Combination of any two of the following (a+b or a+c, or b+c):

                    1. Use of oral, injected or implanted hormonal methods of contraception

                    2. Placement of an intrauterine device (IUD) or intrauterine system (IUS)

                    3. Barrier methods of contraception: condom for male partner or occlusive cap

                    4. (diaphragm or cervical/vault caps) with spermicidal
                       foam/gel/film/cream/vaginal suppository

          9. Patients with any psychological, familial, sociological or geographical condition
             potentially hampering compliance with the study protocol and follow-up schedule; those
             conditions should be discussed with the patient before registration in the trial.