Clinical Trials /

BI 894999 First in Human Dose Finding Study in Advanced Malignancies

NCT02516553

Description:

This study is open to adults with different types of advanced cancer (solid tumours). The study is also open to patients with diffuse large B-cell lymphoma in whom previous treatment was not successful. In some countries, adolescents who are at least 15 years old and who are diagnosed with NUT carcinoma can also participate. No standard treatment exists for this rare and aggressive form of cancer. The purpose of this study is to find out the highest dose of BI 894999 that people can tolerate. BI 894999 is tested for the first time in humans. Participants take tablets once daily. The study also tests whether participants can tolerate BI 894999 better when taken continuously or with breaks in between. Participants can stay in the study as long as they benefit from the treatment and can tolerate it. The doctors also regularly check the general health of the participants.

Related Conditions:
  • Diffuse Large B-Cell Lymphoma
  • Malignant Solid Tumor
Recruiting Status:

Recruiting

Phase:

Phase 1

Trial Eligibility

Document

Title

  • Brief Title: BI 894999 First in Human Dose Finding Study in Advanced Malignancies
  • Official Title: An Open Label, Phase Ia/Ib Dose Finding Study With BI 894999 Orally Administered Once a Day in Patients With Advanced Malignancies, With Repeated Administration in Patients With Clinical Benefit

Clinical Trial IDs

  • ORG STUDY ID: 1367.1
  • SECONDARY ID: 2015-001111-12
  • NCT ID: NCT02516553

Conditions

  • Neoplasms
  • NUT Carcinoma

Interventions

DrugSynonymsArms
BI 894999arm A
BI 894999arm B
BI 894999arm C

Purpose

The aim of the phase Ia (dose escalation) part of this trial is to assess-> determine the Maximum Tolerated Dose (MTD) using a continuous dosing schedule A, using an intermittent Schedule B (2 weeks on, one week off in 3-week cycles) and the MTD using an intermittent Schedule C (one week on followed by one week off treatment, repeated every two weeks in 4-week cycles) in patients with solid tumours. In the phase Ib expansion part, the aim is to further evaluate the safety profile of BI 894999 at the dose recommended by the data monitoring committee (DMC). Once the MTD has been determined for both schedules A and B in patients with solid tumours, the MTD will be determined as well in patients with diffuse large B-cell lymphoma (DLBCL), using the DMC recommended schedule for solid tumours

Trial Arms

NameTypeDescriptionInterventions
arm AExperimentalonce daily continuous oral intake in 3-week cycles
  • BI 894999
arm BExperimentalonce daily intermittent oral intake with two weeks on treatment followed by one week off in 3-week cycles
  • BI 894999
arm CExperimentalone week on followed by one week off treatment, repeated every two weeks in 4-week cycles
  • BI 894999

Eligibility Criteria

        Inclusion criteria:

        For all patients

          -  Age 18 years or older at the time of signature of the informed consent.

          -  Life expectancy of at least 12 weeks after the start of the treatment according to the
             investigator's judgement

          -  Male or female patients. Women of childbearing potential* must be ready and able to
             use highly effective methods of birth control per ICH M3(R2) that result in a low
             failure rate of less than 1% per year when used consistently and correctly. A list of
             contraception methods meeting these criteria is provided in the patient information.
             For women of childbearing potential using a contraceptive pill, an additional barrier
             method is necessary due to the potential CYP3A4 inducing effect of BI894999. Male
             patients having a partner of childbearing potential must use condoms and ensure their
             partner is using a highly effective method of birth control as described above, during
             the trial and for at least three months after the end of the trial * Any female who
             has experienced menarche and does not meet the criteria for "women not of childbearing
             potential" as described below.

        Women not of childbearing potential are defined as: women who are postmenopausal (12 months
        with no menses without an alternative medical cause) or who are permanently sterilized
        (e.g., tubal occlusion, hysterectomy, bilateral oophorectomy or bilateral salpingectomy).

        - Written informed consent consistent with ICH-GCP and local legislation

        For patients with solid tumours

          -  Patients with a histologically or cytologically confirmed diagnosis of an advanced
             unresectable and/or metastatic, malignant solid tumour, who have failed conventional
             treatment or for whom no therapy of proven efficacy exists, or who are not amenable to
             standard therapies

          -  Age ≥ legal age to be adult for the given country at the time of signature of the
             informed consent. For NC patients, age 15 years or older at the time of signature of
             the informed consent ( in Germany and South Korea, only legally adult patients may be
             included

          -  Eastern Cooperative Oncology Group (ECOG, R01-0787) performance score 0 or 1 at the
             time of screening. A score of 2 is allowed for NUT carcinoma patients

          -  Recovery of therapy-related toxicities from previous chemotherapy, tyrosine kinase
             inhibitors, hormone therapy, immunotherapy, antibodies, vaccine therapy, or
             radiotherapy to CTCAE ≤ grade 1 (with the exception of alopecia, peripheral sensory
             neuropathy grade 2)

          -  Life expectancy of at least 12 weeks after the start of the treatment according to the
             investigator's judgement

          -  Male or female patients. Women of childbearing potential* must be ready and able to
             use highly effective methods of birth control per ICH M3(R2) that result in a low
             failure rate of less than 1% per year when used consistently and correctly. A list of
             contraception methods meeting these criteria is provided in the patient information.
             For women of childbearing potential using a contraceptive pill, an additional barrier
             method is necessary due to the potential CYP3A4 inducing effect of BI894999. Male
             patients having a partner of childbearing potential must use condoms and ensure their
             partner is using a highly effective method of birth control as described above, during
             the trial and for at least three months after the end of the trial treatment

          -  Written informed consent consistent with ICH-GCP and local legislation. For adolescent
             NC patients aged 15 years to < legal adult age, written assent of the patient and
             written informed consent of the parents (both or one according to national regulation)
             or legal guardian of the adolescent

          -  Written informed consent for tumour biopsies in the escalation phase Ia

               -  Optional for those patients until extension of the MTD cohort,

               -  Optional for the patients in the extension of MTD cohort at the same time points
                  as described below for the expansion phase. For these patients in the extension
                  of the MTD cohort, if they have an accessible lesion for biopsy, they will be
                  offered optional consent for tumour biopsies

          -  In addition, all patients included in the expansion Phase Ib must:

          -  Have been diagnosed with one of the four types of tumours selected:

               -  small cell lung cancer (SCLC)

               -  metastatic castrate resistant prostate cancer (mCRPC)

               -  colorectal cancer (CRC)

               -  NUT carcinoma (NC) (for which the "midline" origin is not a prerequisite)

          -  Have failed conventional treatments or who are not amenable to standard therapies (per
             criterion 1) that specifically include for:

               -  SCLC: a platinum-based therapy (previous treatment with topotecan is not
                  mandatory)

               -  mCRPC: a hormonal agent (abiraterone, enzalutamide, or apalutamide) and a taxane
                  (docetaxel or cabazitaxel)

               -  CRC: fluoropyrimidine, oxaliplatin and irinotecan, bevacizumab for patients
                  eligible to this treatment and an anti-epidermal growth factor receptor (EGFR) in
                  RAS (Rat Sarcoma Virus) wild type metastatic CRC.

          -  Have measurable disease (radiated lesions and lesions used for biopsy do not qualify
             as target lesions), according to RECIST 1.1 (R09-0262) (for NC patients only
             nonmeasurable disease is acceptable); or according to PCWG3 (R17-3377) for the mCRPC
             cohort (see point 5 of inclusion criteria below, specific to mCRPC patients)

          -  Have progressive disease within the last 6 months, according to RECIST 1.1 (R09-0262)
             or according to PCWG3 (R17-3377) for the mCRPC cohort (see point 5 of inclusion
             criteria below, specific to mCRPC patients). NC patients do not need to show
             progression per RECIST 1.1 (for example, if newly diagnosed).

          -  Have a tumour lesion accessible for biopsies (pre- and at steady state under treatment
             in Cycle 1, ideally from the same anatomic lesion) (except for mCRPC patients having
             only bone metastases or for patients with therapeutic INR because of treatment with a
             vitamin K antagonist or a novel oral anticoagulant. Biopsies are optional for NC
             patients

          -  Give written informed consent for two tumour biopsies, one at screening and one after
             start of treatment, between Day 8 and Day 11 of Cycle 1 (or between day 3 and day 8 if
             the day of biopsy in Cycle 1 needs to be moved as explained in Section 3.1) (when
             applicable)

          -  In addition, all patients in the mCRPC expansion cohort of Phase Ib must have:

          -  Histologically or cytologically confirmed adenocarcinoma of the prostate

          -  Radiographic evidence of metastatic prostate cancer (stage M1 or D2). Distant
             metastases evaluable by bone scan, CT scan, or MRI within 28 days before the start of
             study treatment.

          -  PSA ≥ 5 ng/mL (if no measurable disease by RECIST 1.1)

          -  Prior surgical or chemical castration with a serum testosterone of <50 ng/dL (< 1.7
             nmol/L) by luteinizing hormone releasing level hormone (LHRH) agonist or antagonist,
             or by abiraterone or by enzalutamide or apalutamide. If the actual method of
             castration is LHRH agonist or antagonist, the patient must be willing to continue the
             use of LHRH agonist or antagonist during protocol treatment.

          -  Progressive disease defined as at least one of the following:

               -  Progressive measurable disease: using conventional solid tumour criteria RECIST
                  1.1

               -  Bone scan progression: at least two new lesions on bone scan plus a rising PSA as
                  described in point c below

               -  Increasing PSA level: at least two consecutive rising PSA values over a reference
                  value (PSA no.1) taken at least 1 week apart. A third PSA (PSA no. 3) is required
                  to be > than PSA no. 2; if not, a fourth PSA (PSA no. 4) is required to be > to
                  PSA no. 2

        In patients with DLBCL

          -  Patients with histologically confirmed DLBCL who have failed 2 or more lines of
             systemic therapy including an anti-CD-20 therapy and an anthracycline or who are not
             amenable to standard therapies but have an indication for therapy as per
             investigator's judgement. Standard therapies may also include but are not limited to
             CAR-T cells therapy, depending on approved therapies in the country where the patient
             is treated

          -  ECOG Performance Status 0, 1 or 2 at the time of screening

          -  Measurable disease (radiated lesions do not qualify as target lesions) according to
             according to RECIL 2017 on the CT scan part of the FDG/PET-CT scan

          -  Recovery of therapy-related toxicities from previous anti-lymphoma therapy to CTCAE <=
             grade 1 (with the exception of alopecia, peripheral sensory neuropathy grade 2)

          -  written informed consent for tumour biopsies (optional)

          -  Further inclusion criteria apply

        Exclusion criteria:

        For all patients:

          -  Inability to swallow tablets

          -  Additional other serious illness, concomitant non-oncological disease (e.g. active
             infectious disease including an active infection with SARS-CoV-2 confirmed by a PCR
             test or had one in the prior 6 weeks or active hepatitis (Hep) B infection as defined
             by positive Hep B DNA test, active Hep C infection as defined by positive Hep C RNA
             test and human immunodeficiency virus (HIV) infection (positive result in established
             HIV diagnostic assay), or ongoing toxicity from prior therapies considered by the
             investigator to potentially compromise patient's safety in this trial

          -  Serum creatinine greater than 1.5 mg/dL (>132 µmol/L, SI unit equivalent)

          -  Women who are pregnant, nursing, or who plan to become pregnant while in the trial

          -  Treatment with other investigational drugs or participation in another clinical
             interventional trial within the past four weeks or within five times the half-life of
             the previous investigational drug, whichever is shorter, before start of therapy or
             concomitant with this trial

          -  Patients unable to comply with the protocol

          -  Patients who are actively abusing alcohol or drugs. Since no alcohol or drug testing
             is required per protocol, it is at the investigator's discretion to determine abuse.

        For patients with solid tumours:

          -  Additional other serious illness , concomitant non-oncological disease (e.g. active
             infectious disease or known chronic Hepatitis B/Hepatitis C infection and HIV), or
             ongoing toxicity from prior therapies considered by the investigator to potentially
             compromise patient's safety in this trial

          -  History or presence of cardiovascular abnormalities deemed clinically relevant by the
             investigator such as uncontrolled hypertension, congestive heart failure NYHA
             classification of 3, unstable angina or poorly controlled arrhythmia. Myocardial
             infarction within 6 months prior to study entry.Left Ventricular Ejection Fraction
             (LVEF) less than 50% at baseline

          -  Clinical evidence of symptomatic progressive brain or leptomeningeal disease during
             the last 28 days before the start of treatment with BI 894999

          -  Absolute neutrophil count less than 1500/mm^3

          -  Platelet count less than 100 000/mm^3

          -  Bilirubin greater than 1.5 mg/dL (>26 µmol/L, SI unit equivalent) (except known
             Gilbert's syndrome, accepted up to 2 mg/dL or up to 34.2 µmol/L in this case)

          -  Aspartate amino transferase (AST) and/or alanine amino transferase (ALT) greater than
             2.5 times the upper limit of normal (if related to liver metastases, greater than five
             times the upper limit of normal)

          -  Treatment with other investigational drugs or participation in another clinical
             interventional trial within the past four weeks (past two weeks for NC patients) or
             within five times the half-life of the previous investigational drug, whichever is the
             shorter, before start of therapy or concomitant with this trial

          -  Systemic anti-cancer therapy within four weeks (past two weeks for NC patients) or
             five times the half-life of the drug, whichever is shorter. Radiotherapy given for
             curative intent or other than palliative radiotherapy within the past four weeks
             before start of therapy or concomitantly with this trial. This These restrictions does
             not apply to LHRH agonists or antagonists, steroids (given at a stable dose in the
             last four weeks) used for palliative intent, bisphosphonates, and denosumab and to
             palliative radiotherapy (no wash out required)

        For patients with DLBCL:

          -  Patient is eligible for curative salvage high dose therapy followed by stem cell
             transplant.

          -  Primary central nervous system (CNS) lymphoma or known CNS involvement

          -  Prior allogeneic bone marrow or stem cell transplant

          -  High-dose therapy with stem cell support <3 months prior to visit 1

          -  AST or ALT >2.5 x upper limit of normal (CTCAE grade 2 or higher)

          -  Total bilirubin >1.5 x upper limit of normal (CTCAE grade 2 or higher)

          -  Absolute neutrophil count <1.0 x 10^9/L(without growth factor support)

          -  Platelets <100 x 10^9/L (without transfusions)

          -  Significant concurrent medical disease or condition which according to the
             investigator's judgement would either compromise patient safety or interfere with the
             evaluation of the safety of the test drug, e.g. symptomatic congestive heart failure,
             unstable angina pectoris, myocardial infarction within 6 months prior to study entry,
             cardiac arrhythmia requiring therapy with the exception of extra systoles or minor
             conduction abnormalities

          -  Chronic or ongoing infection requiring treatment at the time of enrolment or within
             the previous two weeks, e.g. active infectious disease or known Hepatitis B/Hepatitis
             C infection, HIV

          -  Systemic anti-DLBCL therapy within the past two weeks or five times the half-life of
             the drug, whichever is shorter (palliative radiotherapy and agents used for palliative
             reasons for example steroids and bisphosphonates, are allowed)

          -  Further exclusion criteria apply
      
Maximum Eligible Age:N/A
Minimum Eligible Age:18 Years
Eligible Gender:All
Healthy Volunteers:No

Primary Outcome Measures

Measure:In phase Ib: Number of patients experiencing DLTs from start of treatment until end of treatment (in all cycles) as assessed approximately every 3 weeks after Cycle 2 (at the end of each new cycle) in order to determine the recommended phase II dose
Time Frame:average of 12 months
Safety Issue:
Description:

Secondary Outcome Measures

Measure:efficacy endpoint in phases Ia and Ib: Objective response (OR), defined as CR or PR with tumour assessment during treatment period for each schedule
Time Frame:every 6 weeks, average of 4 months
Safety Issue:
Description:
Measure:efficacy endpoint in phase Ib: Progression-free Survival (PFS) or radiological PFS
Time Frame:average of 5 months
Safety Issue:
Description:
Measure:efficacy endpoint in phase Ib: Best overall response with an evaluation of approximately every 2 cycles (6 weeks if no delays) during the entire treatment period
Time Frame:every 6 weeks, average of 4 months
Safety Issue:
Description:
Measure:In both phases: Cmax,ss after single dose and at steady state, as measured during the first cycle (3 weeks) for Schedules A and B, the first 4 weeks for Schedule C)
Time Frame:up to 4 weeks
Safety Issue:
Description:
Measure:In both phases: AUC0-24 after single dose and at steady state, as measured during the first cycle (3 weeks) for Schedules A and B, the first 4 weeks for Schedule C)
Time Frame:up to 4 weeks
Safety Issue:
Description:
Measure:In both phases: AUC tau, ss after single dose and at steady state, as measured during the first cycle (3 weeks) for Schedules A and B, the first 4 weeks for Schedule C)
Time Frame:up to 4 weeks
Safety Issue:
Description:
Measure:Phase Ia: Number of patients experiencing DLTs from start of treatment until end of treatment (in all cycles) for each of the schedules (A, B and C) in patients with solid tumours and in schedule B in the DLBCL cohort
Time Frame:average of 12 months
Safety Issue:
Description:
Measure:In both phases: Cmax after single dose and at steady state, as measured during the first cycle (3 weeks) for Schedules A and B, the first 4 weeks for Schedule C)
Time Frame:up to 4 weeks
Safety Issue:
Description:
Measure:efficacy endpoint in phase Ib: Prostate Specific Antigen (PSA) response (decline in PSA value ≥50% from baseline) in patients with Metastatic Castration Resistant Prostate Cancer (mCRPC)
Time Frame:average of 12 months
Safety Issue:
Description:
Measure:Overall survival in patients with NUT Carcinoma (NC)
Time Frame:Up to 29 months
Safety Issue:
Description:

Details

Phase:Phase 1
Primary Purpose:Interventional
Overall Status:Recruiting
Lead Sponsor:Boehringer Ingelheim

Trial Keywords

  • NUT midline carcinoma

Last Updated

January 12, 2021