Clinical Trials /

Anti-ICOS Monoclonal Antibody MEDI-570 in Treating Patients With Relapsed or Refractory Peripheral T-cell Lymphoma Follicular Variant or Angioimmunoblastic T-cell Lymphoma

NCT02520791

Description:

This phase I trial studies the side effects and best dose of anti-inducible T-cell co-stimulator (ICOS) monoclonal antibody MEDI-570 in treating patients with peripheral T-cell lymphoma follicular variant or angioimmunoblastic T-cell lymphoma that has returned after a period of improvement (relapsed) or has not responded to previous treatment (refractory). Immunotherapy with monoclonal antibodies, such as anti-ICOS monoclonal antibody MEDI-570, may induce changes in the body's immune system and may interfere with the ability of tumor cells to grow and spread.

Related Conditions:
  • Angioimmunoblastic T-Cell Lymphoma
  • Follicular Lymphoma
  • Peripheral T-Cell Lymphoma
  • Primary Cutaneous T Cell Non-Hodgkin Lymphoma
Recruiting Status:

Recruiting

Phase:

Phase 1

Trial Eligibility

Document

Title

  • Brief Title: Anti-ICOS Monoclonal Antibody MEDI-570 in Treating Patients With Relapsed or Refractory Peripheral T-cell Lymphoma Follicular Variant or Angioimmunoblastic T-cell Lymphoma
  • Official Title: A Phase I Trial of MEDI-570 in Patients With Relapsed/Refractory Peripheral T-Cell Lymphoma (PTCL) Follicular Variant and Angioimmunoblastic T-Cell Lymphoma (AITL)

Clinical Trial IDs

  • ORG STUDY ID: NCI-2015-01271
  • SECONDARY ID: NCI-2015-01271
  • SECONDARY ID: PJC-021
  • SECONDARY ID: 9930
  • SECONDARY ID: 9930
  • SECONDARY ID: UM1CA186644
  • NCT ID: NCT02520791

Conditions

  • Follicular T-Cell Lymphoma
  • Grade 1 Follicular Lymphoma
  • Grade 2 Follicular Lymphoma
  • Grade 3a Follicular Lymphoma
  • Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma
  • Recurrent Angioimmunoblastic T-Cell Lymphoma
  • Recurrent Follicular Lymphoma
  • Recurrent Mature T- Cell and NK-Cell Non-Hodgkin Lymphoma
  • Recurrent Mycosis Fungoides
  • Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
  • Refractory Angioimmunoblastic T-Cell Lymphoma
  • Refractory Follicular Lymphoma
  • Refractory Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma
  • Stage IB Mycosis Fungoides AJCC v7
  • Stage II Mycosis Fungoides AJCC v7
  • Stage III Cutaneous T-Cell Non-Hodgkin Lymphoma
  • Stage III Mycosis Fungoides AJCC v7
  • Stage IV Cutaneous T-Cell Non-Hodgkin Lymphoma
  • Stage IV Mycosis Fungoides AJCC v7

Interventions

DrugSynonymsArms
Anti-ICOS Monoclonal Antibody MEDI-570MEDI-570Treatment (MEDI-570)

Purpose

This phase I trial studies the side effects and best dose of anti-inducible T-cell co-stimulator (ICOS) monoclonal antibody MEDI-570 in treating patients with peripheral T-cell lymphoma follicular variant or angioimmunblastic T-cell lymphoma that has returned after a period of improvement (relapsed) or has not responded to previous treatment (refractory). Immunotherapy with monoclonal antibodies, such as anti-ICOS monoclonal antibody MEDI-570, may induce changes in the body's immune system and may interfere with the ability of tumor cells to grow and spread.

Detailed Description

      PRIMARY OBJECTIVES:

      I. To determine the safety, maximum tolerated dose and recommended phase II dose (RP2D) of
      MEDI-570 (anti-ICOS monoclonal antibody MEDI-570) in patients with refractory/relapsed
      peripheral T-cell lymphoma-not otherwise specified (PTCL-NOS), angioimmunoblastic T-cell
      lymphoma (AITL), follicular lymphoma, mycosis fungoides (MF) and cutaneous T-cell lymphomas
      (CTCL).

      SECONDARY OBJECTIVES:

      I. To evaluate the pharmacokinetic profile of MEDI-570. II. To evaluate the overall response
      rate (ORR) and progression free survival (PFS) of MEDI-570 at all dose levels and in a
      10-patient expansion cohort at the maximum tolerated dose (MTD).

      III. To determine short and long term effects of MEDI-570 at all dose levels on the immune
      system and on T-cell lymphocyte subsets.

      IV. To determine the relationship between ICOS expression on tumor cells and response to
      MEDI-570.

      EXPLORATORY OBJECTIVES:

      I. To evaluate biomarkers of response and resistance to MEDI-570 in the study population.

      OUTLINE: This is a dose-escalation study.

      Patients receive anti-ICOS monoclonal antibody MEDI-570 intravenously (IV) over 1-4 hours on
      day 1. Treatment repeats every 21 days for up to 12 cycles in the absence of disease
      progression or unacceptable toxicity.

      After completion of study treatment, patients are followed up at 30 days and then every 6
      weeks for 12 weeks.
    

Trial Arms

NameTypeDescriptionInterventions
Treatment (MEDI-570)ExperimentalPatients receive anti-ICOS monoclonal antibody MEDI-570 IV over 1-4 hours on day 1. Treatment repeats every 21 days for up to 12 cycles in the absence of disease progression or unacceptable toxicity.
  • Anti-ICOS Monoclonal Antibody MEDI-570

Eligibility Criteria

        Inclusion Criteria:

          -  Pathologic diagnosis of one of the following:

               -  For dose escalation:

                    -  Confirmed diagnosis of peripheral T-cell lymphoma (PTCL) or
                       angioimmunoblastic T-cell lymphoma (AITL) that is refractory to at least one
                       line of therapy; anaplastic large cell lymphoma (ALCL) and natural killer
                       T-cell lymphoma nasal type (NKTCL) are excluded

                    -  Advanced stage cutaneous T-cell lymphoma (CTCL), specifically CTCL NOS,
                       small/medium T-cell lymphoma (SMTCL) and mycosis fungoides (MF) stage IB,
                       IIA, IIB, III and IV that have relapsed after at least one specific prior
                       therapy (e.g. interferon, photopheresis, denileukin difitox, bexarotene,
                       etc); anaplastic cutaneous large cell lymphoma (ACLCL) and lymphomatoid
                       papulopsis are excluded

                    -  Follicular lymphoma grade 1, 2 or 3A that meets the following criteria:

                         -  Relapsed or refractory to at least 2 lines of therapy AND

                         -  Relapsed or refractory post autologous cell transplantation (HCT)

               -  For dose expansion/dose confirmation phase:

                    -  Patients with confirmed diagnosis of peripheral T-cell lymphoma (PTCL)
                       follicular type or angioimmunoblastic T-cell lymphoma (AITL) that is
                       refractory to at least one line of therapy

          -  At least 14 days from the last therapy dose or 5 half-lives (whichever is shorter),
             and resolution of toxicity related to the last therapy, excluding grade 2 or less
             peripheral neuropathy and alopecia; for radiation therapy, a minimum of 2 weeks and
             resolution of all acute toxicity will be required

          -  Patients must have at least one measurable lesion that can be accurately measured with
             spiral computed tomography (CT) scan, magnetic resonance imaging (MRI) scan, or
             physical exam (by calipers only); (PTCL, AITL and follicular lymphoma patients will be
             assessed on this study using the Lugano criteria for the evaluation of lymphomas; CTCL
             and MF patients will be assessed using International Society for Cutaneous Lymphomas
             [ISCL] and European Organization for Research and Treatment of Cancer [EORTC
             criteria])

          -  Eastern Cooperative Oncology Group (ECOG) performance status =< 2 (Karnofsky >= 60%)

          -  Life expectancy of greater than 6 months

          -  Leukocytes >= 3,000/mcL

          -  Hemoglobin >= 80 d/L (or >= 8 g/dL)

               -  Patients must not have received a transfusion, with packed red blood cells,
                  within 2 weeks prior to sample being collected

          -  Absolute neutrophil count (ANC) >= 1,500/mcL

          -  Platelets (PLT) >= 50,000/mcL

          -  Absolute CD4 count > 100 cells/uL

          -  Total bilirubin < 1.5 upper limit of normal (ULN)

          -  Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase
             [SGOT])/alanine aminotransferase (ALT) (serum glutamic pyruvic transaminase [SGPT]) =<
             2.5 x institutional upper limit of normal

          -  Creatinine < 1.5 mg/dl (= 132 umol/L) or

          -  Creatinine clearance >= 50 mL/min/1.73 m^2 for patients with creatinine levels above
             institutional normal

          -  In patients with bone marrow involvement the minimum requirement is as follows:

               -  Leukocytes >= 2000/mcL

               -  ANC >= 1000/mcL

               -  PLT >= 50 000/mcL

          -  Availability of tissue for correlative studies; patients must have at least 6-8
             unstained slides of archived formalin-fixed, paraffin-embedded tumor tissue available;
             if not enough archived tissue is available, a fresh tumor biopsy prior to study
             initiation is mandatory; for patients who have undergone a fresh baseline biopsy at
             baseline, the archived tissue is not mandatory

          -  The effects of MEDI-570 on the developing human fetus are unknown; for this reason,
             women of child-bearing potential and men must agree to use adequate contraception
             (hormonal or barrier method of birth control; abstinence) prior to study entry, during
             the study participation, and for 3 months after the last dose of the drug; should a
             woman become pregnant or suspect she is pregnant while she or her partner is
             participating in this study, she should inform her treating physician immediately; men
             treated or enrolled on this protocol must have either had a prior vasectomy or agree
             to use effective contraception prior to the study, during the study, and for 3 months
             after the last dose of the drug; males should avoid fathering children during and for
             at least three months after therapy is completed

          -  Ability to understand and the willingness to sign a written informed consent document

        Exclusion Criteria:

          -  Patients who are receiving any other investigational agents

          -  Patients with known brain metastases should be excluded from this clinical trial
             because of their poor prognosis and because they often develop progressive neurologic
             dysfunction that would confound the evaluation of neurologic and other adverse events

          -  History of allergic reactions attributed to compounds of similar chemical or biologic
             composition to MEDI-570 or history of anaphylaxis to any biological component

          -  Any history or evidence of opportunistic infection within 6 months of screening
             including tuberculosis, severe cytomegalovirus (CMV) or herpetic infections (such as
             disseminated herpes, herpes encephalitis, ophthalmic herpes)

          -  Evidence of active infection by hepatitis B and/or C; active viral infection by
             hepatitis B and hepatitis C could be associated with cytopenias (due to hypersplenism
             or due to the active virus itself), which could add further risk when a potential
             immunosuppressive medication is used; for patients with hepatitis B treated with
             anti-virals to undetectable viral load, and for patients with hepatitis C with
             undetectable ribonucleic acid (RNA) levels and no evidence of liver damage, enrollment
             may be considered and should discuss first with study's principal investigator

          -  History of human immunodeficiency virus (HIV) infection; the human immunodeficiency
             virus (HIV) depletes CD4 T-cells and could also have a role in T-cell anergy; since
             MEDI-570 preferentially affects CD4 T-cell numbers and function, and the resultant
             immunosuppression by this agent can be prolonged, exposing HIV patients to MEDI-570
             will place them in an unnecessary risk of developing infections due to an underlying
             acquired cellular immunity defect

          -  History of primary immunodeficiency

          -  Receipt of live or live attenuated vaccine within 12 weeks prior to enrollment

          -  All potential patients must undergo a tuberculosis (TB) test prior to study entry to
             rule out active or latent tuberculosis (either purified protein derivative [PPD] or
             QuantiFERON-TB Gold, whichever is preferred and available at the institution);
             patients with a history of TB (even if treated), or evidence of active or latent TB,
             are excluded; the diagnosis of active TB is defined per current guidelines; patients
             with a positive TB test (e.g. PPD or QuantiFERON-TB Gold) will be excluded; patients
             with history of Bacille-Calmette-Guerin (BCG) vaccination will be tested with
             QuantiFERON-TB Gold test in order to rule out exposure to TB

          -  Patients who have undergone allogeneic stem cell transplantation

          -  Patients who have undergone autologous stem cell transplantation within 3 months from
             study entry

          -  Major surgery within 30 days prior or during the study period

          -  Uncontrolled intercurrent illness including, but not limited to, ongoing or active
             infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
             arrhythmia, or psychiatric illness/social situations that would limit compliance with
             study requirements

          -  Pregnant women are excluded from this study due to the potential toxicity in
             pre-clinical reproductive studies; in addition, there is an unknown but potential risk
             for adverse events in nursing infants secondary to treatment of the mother with
             MEDI-570; breastfeeding should be discontinued if the mother is treated with MEDI-570

          -  Patients with active, known, or suspected autoimmune disease, except in these
             conditions:

               -  Participants with well-controlled asthma and/or mild allergic rhinitis (seasonal
                  allergies) are eligible

               -  Participants with the following disease conditions are also eligible:

                    -  Vitiligo,

                    -  Type 1 diabetes mellitus

                    -  Residual hypothyroidism due to autoimmune condition only requiring hormone
                       replacement

                    -  Euthyroid participants with a history of Grave's disease (participants
                       suspected autoimmune thyroid disorders must be negative for thyroglobulin
                       and thyroid peroxidase antibodies and thyroid stimulating immunoglobulin
                       prior to first dose of study drug)

                    -  For patients with ITP (idiopathic thrombocytopenic purpura) or AIHA
                       (autoimmune hemolytic anemia), a case by case discussion with study
                       principal investigator (PI) may be considered

                    -  Patients not receiving systemic therapy (i.e., systemic steroids or biologic
                       therapy with disease modifying anti-rheumatic drugs [DMARDs]) within 2 years
                       can be also eligible

          -  Patients with a weight of < 39 kg
      
Maximum Eligible Age:N/A
Minimum Eligible Age:18 Years
Eligible Gender:All
Healthy Volunteers:No

Primary Outcome Measures

Measure:Incidence of toxicity and safety of anti-inducible T-cell co-stimulator (ICOS) monoclonal antibody MEDI-570
Time Frame:Up to 12 weeks after completion of study treatment
Safety Issue:
Description:Graded according to the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. Frequency and severity of adverse events will be tabulated using counts and proportions detailing frequently occurring, serious and severe events of interest. Adverse events will be summarized using all adverse events experienced, although a sub-analysis may be conducted including only those adverse events in which the treating physician deems possibly, probably or definitely attributable to one or both study treatments.

Secondary Outcome Measures

Measure:Pharmacokinetics (PK), such as plasma concentration and PK parameters, of monoclonal antibody therapy
Time Frame:Prior to dose on day 1, immediately after dose, and at 6 minutes, 24, 48 and 72 hours post dose of cycle 1 and cycle 2, and then on day 1 pre-dose of every subsequent cycle
Safety Issue:
Description:Attempts to model associations between pharmacokinetic data with toxicity profiles will be performed primarily using descriptive statistics; however, logistic regression may be used if warranted.
Measure:Overall response rate
Time Frame:Up to 36 weeks
Safety Issue:
Description:Assessed per the Revised Response Criteria for Malignant Lymphoma of the Lugano Classification. Summary statistics, such as the mean, median, counts and proportion, will be used to describe patients' clinical characteristics. For all statistical tests, two-sided tests will be performed and no p-value adjustment performed due to the exploratory nature of these tests. A p-value of 0.05 or less will be considered statistically significant.
Measure:Progression-free survival
Time Frame:Up to 12 weeks after completion of study treatment
Safety Issue:
Description:Summary statistics, such as the mean, median, counts and proportion, will be used to describe patients' clinical characteristics. For all statistical tests, two-sided tests will be performed and no p-value adjustment performed due to the exploratory nature of these tests. A p-value of 0.05 or less will be considered statistically significant.
Measure:Immunogenicity
Time Frame:Up to 36 weeks
Safety Issue:
Description:Summary statistics, such as the mean, median, counts and proportion, will be used to describe patients' clinical characteristics. For all statistical tests, two-sided tests will be performed and no p-value adjustment performed due to the exploratory nature of these tests. A p-value of 0.05 or less will be considered statistically significant.
Measure:Overall survival (OS)
Time Frame:Up to 12 weeks after completion of study treatment
Safety Issue:
Description:Summary statistics, such as the mean, median, counts and proportion, will be used to describe patients' clinical characteristics. For all statistical tests, two-sided tests will be performed and no p-value adjustment performed due to the exploratory nature of these tests. A p-value of 0.05 or less will be considered statistically significant.

Details

Phase:Phase 1
Primary Purpose:Interventional
Overall Status:Recruiting
Lead Sponsor:National Cancer Institute (NCI)

Last Updated

February 20, 2020