Inclusion Criteria:

          1. Written informed consent

          2. Women aged ≥ 18 years

          3. Histologically confirmed invasive breast cancer

          4. American Joint Committee on Cancer (AJCC) stage: ⅡA-ⅢC, no evidence of metastasis

          5. At least one measurable disease in breast and/or axilla

          6. ER and/or progesterone receptor(PgR) positive(≥10% of the cells by IHC)

          7. HER2 negative(by IHC and/or FISH)

          8. Premenopause status (estradiol in premenopausal range or with normal menstrual cycle
             in the past 6 months with no use of hormonal drugs)

          9. Eastern Cooperative Oncology Group（ECOG）score 0-1, an estimated life expectancy of at
             least 12 months

         10. Adequate bone marrow function: Leukocyte ≥ 3.0*109/L; Neutrophil ≥ 1.5*109/L; Hb ≥
             100g/L; Platelet(PLT） ≥ 80*109/L

         11. Adequate liver, renal function and coagulation function: Alanine transaminase（ALT）
             and/or Aspartate transaminase（AST）≤ 1.5 upper normal limit（UNL）, total bilirubin
             ≤upper normal limit, creatinine ≤ 110umol/L, Creatinine clearance > 60ml/min, blood
             urea nitrogen（BUN） ≤ 7.1mmol/L, activated partial thromboplastin time（APTT） ≤ 1.5
             upper normal limit（UNL）

         12. Women with child-bearing potential must have a negative pregnancy test (urine or
             serum) within 7 days of drug administration and agree to use an acceptable method of
             birth control to avoid pregnancy for the duration of the study

         13. Serological records of hepatitis B virus（HBV）and hepatitis C virus（HCV） testing.

        Exclusion Criteria:

          1. Stage IV breast cancer

          2. Prior systemic or loco-regional treatment of breast cancer

          3. Any anti-neoplastic treatment within 28 days before the beginning of study

          4. Known severe hypersensitivity to any drugs in this study

          5. History of malignancy within 5 years except carcinoma in situ of cervix or skin basal
             cell carcinoma that had received adequate treatment

          6. Peripheral neuropathy ≥ 2°, according to National Cancer Institute(NCI) Common
             Terminology Criteria for Adverse Events(CTCAE)(Version 4.0)

          7. Any cardiac or pulmonary dysfunction defined as following:

        (1) ≥ 3° symptomatic congestive heart failure (CHF) according to NCI CTCAE(Version 4.0) or
        ≥ 2° CHF according to New York Heart Association（NYHA）

        (2) Angina that needs anti-anginal drugs, advanced conduction abnormality or significant
        vascular disease

        (3) Uncontrolled high-risk arrhythmia: atrial tachycardia that silent heart rate >100/min,
        significant ventricular arrythmia or advanced atrioventricular block(2° type II
        atrioventricular or 3° atrioventricular block)

        (4) Poorly controlled hypertension (systolic BP > 180 mmHg or diastolic BP > 100 mmHg)

        (5) Transmural myocardial infarction in EKG

        (6) Long-term oxygen therapy

        8. Uncontrolled severe systemic disease(clinically significant cardiovascular
        disease，pulmonary disease or metabolic disease, wound healing disorder, ulcer, severe
        infection)

        9. Pregnant or breast feeding

        10. Major operation, obvious trauma within 28 days before randomization or planned major
        operation during the study

        11. Known active hepatic disease due to hepatitis B virus, hepatitis C virus, auto-immune
        liver disease or sclerosing cholangitis

        12. Known HIV infection

        13. Any reasons investigators consider that not suitable for the study