Inclusion Criteria:

1. Age greater than or equal to 18 years

2. Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1

3. Life expectancy greater than or equal to 12 weeks

4. Participants must have any of the following tumor types, confirmed by available
pathology records or current biopsy, that is advanced, nonresectable, or recurrent
and progressing since last antitumor therapy, and for which no alternative standard
therapy exists: pancreatic adenocarcinoma, renal clear cell carcinoma, SCCHN
(squamous cell carcinoma of head and neck), NSCLC (non-small cell lung cancer),
colorectal cancer (CRC), hepatocellular carcinoma (HCC), ovarian serous epithelial
cancer, bladder transitional cancer, cervical cancer, and triple-negative breast
cancer

5. Prior chemotherapy or immunotherapy (tumor vaccine, cytokine, or growth factor given
to control the cancer) must have been completed at least 4 weeks before study drug
administration, and all adverse events (AEs) have either returned to baseline or
stabilized.

6. Prior definitive radiation therapy must have been completed at least 6 weeks before
study drug administration and the irradiated lesions should show evidence of
progression if they are intended to be considered target lesions. Prior palliative
radiotherapy must be completed at least 2 weeks before study drug administration. The
radiotherapy related side effects must have resolved before the study entry. No
radiopharmaceuticals (strontium, samarium) will be allowed within 8 weeks before
study drug administration.

7. Participants must have accessible tumors and consent to repeated biopsy for
performance of correlative tissue studies

8. Must have at least one measurable lesion per irRECIST (immune-related Response
Evaluation Criteria Criteria in Solid Tumors):

- At least 1 lesion of greater than or equal to 10 mm in the longest diameter for
a non-lymph node or greater than or equal to 15 mm in the short-axis diameter
for a lymph node that is serially measurable according to irRECIST using
computerized tomography/magnetic resonance imaging (CT/MRI)

- Lesions that have had definitive external beam radiotherapy or locoregional
therapies such as radiofrequency (RF) ablation or brachytherapy must show
evidence of progressive disease to be deemed a target lesion

9. Prior treated brain or meningeal metastases must be without evidence of progression
(confirmed by MRI) for at least 8 weeks and off immunosuppressive doses of systemic
steroids (greater than 10 mg/day prednisone or equivalent) for at least 4 weeks
before study drug administration

10. Immunosuppressive doses of systemic medications, such as steroids or absorbed topical
steroids (doses greater than 7.5 to 10 mg/day prednisone or equivalent) must be
discontinued at least 2 weeks before study drug administration.

11. Participants with prior Hepatitis B or C are eligible on the condition that
participants have adequate liver function as defined by Inclusion Criterion number 16
and Exclusion Criterion number 5

12. Left ventricular ejection fraction (LVEF) greater than 50% on echocardiography or
multiple gated acquisition (MUGA) scan

13. Adequate renal function defined as serum creatinine less than 1.5 X ULN (upper limit
of normal) or use SI units or calculated creatinine clearance greater than or equal
to 50 mL/min per the Cockcroft and Gault formula

14. Adequate bone marrow function:

- Absolute neutrophil count (ANC) greater than or equal to 1500/mm3 (greater than
or equal to 1.5 X 103/ul)

- Platelets greater than or equal to 100,000/mm3 (greater than or equal to 100 X
109/L)

- Hemoglobin greater than or equal to 9.0 g/dL

15. Adequate liver function:

- Total bilirubin less than or equal to 1.5 X ULN except for unconjugated
hyperbilirubinemia of Gilbert's syndrome

- Alkaline phosphatase, alanine aminotransferase (ALT), and aspartate
aminotransferase (AST) less than or equal to 3 X ULN (less than or equal to 5 X
ULN if participant has liver metastases). If alkaline phosphatase is greater
than 3 X ULN (in absence of liver metastases) or greater than 5 X ULN (in
presence of liver metastases) AND the participant also is known to have bone
metastases, the liver specific alkaline phosphatase must be separated from the
total and used to assess the liver function instead of total alkaline
phosphatase

16. Adequate blood coagulation function as evidenced by an International Normalized Ratio
(INR) less than or equal to 1.5

17. Willing and able to comply with all aspects of the protocol

18. Provide written informed consent prior to any study specific screening procedures

19. Females must not be lactating or pregnant at screening or baseline (as documented by
a negative beta-human chorionic gonadotropin [B-hCG] test with a minimum sensitivity
of 25 IU/L or equivalent units of B-hCG). A separate baseline assessment is required
if a negative screening pregnancy test was obtained more than 72 hours before the
first dose of study drug. All females will be considered to be of childbearing
potential unless they are postmenopausal (at least 12 months consecutive amenorrheic,
in the appropriate age group, and without other known or suspected cause) or have
been sterilized surgically (ie, bilateral tubal ligation, total hysterectomy, or
bilateral oophorectomy, all with surgery at least 1 month before dosing). Females of
childbearing potential must not have had unprotected sexual intercourse within 30
days prior to study entry and must agree to use a highly effective method of
contraception, from the last menstrual period prior to initiation of treatment,
during Treatment Cycles, and for 30 days after the final dose of study treatment, and
have a male partner who uses a condom. Highly effective contraception includes:

- Double barrier methods of contraception such as condom plus diaphragm or
cervical/vault cap with spermicide

- Placement of an intrauterine device

- Established hormonal contraceptive methods: oral, injectable, or implant.
Females who are using hormonal contraceptives must have been on a stable dose of
the same hormonal contraceptive product for at least 4 weeks prior to dosing and
must continue to use the same contraceptive during the study and for 30 days
after study drug discontinuation. Female participants exempt from this
requirement are participants who practice total abstinence or have a male
partner who is vasectomized with confirmed azoospermia. If currently abstinent,
the participant must agree to use a double barrier method as described above if
they become sexually active during the Treatment Cycles, and for 30 days after
study drug discontinuation

20. Male participants must have had a successful vasectomy (confirmed azoospermia) or
they and their female partners must meet the criteria above (ie, not of childbearing
potential or practicing highly effective contraception and use a condom throughout
the study period and for 30 days after study drug discontinuation)

Exclusion Criteria:

1. Other malignancy active within the previous 2 years except for basal or squamous cell
skin cancer, superficial bladder cancer or carcinoma in situ of the cervix or breast
that has completed curative therapy

2. Participants with any active autoimmune disease or a documented history of autoimmune
disease, or history of syndrome that required systemic steroids or immunosuppressive
medications, except for participants with vitiligo or resolved childhood
asthma/atopy. Participants with poorly controlled asthma who require intermittent use
of bronchodilators (such as albuterol) will be excluded from this study.

3. Participants with inflammatory bowel disease

4. Known human immunodeficiency virus (HIV) infection

5. Active infection requiring therapy, including known positive tests for Hepatitis B
surface antigen and hepatitis C virus (HCV) RNA

6. Major surgery within 4 weeks before the first dose of study drug

7. Concurrent medical condition requiring the use of immunosuppressive medications, or
immunosuppressive doses of systemic or absorbable topical corticosteroids except
inhaled or intranasal corticosteroids (with minimal systemic absorption)

8. Inability to take oral medication, or malabsorption syndrome or any other
uncontrolled gastrointestinal condition (eg, nausea, diarrhea, or vomiting) that
might impair the bioavailability of E7046

9. Any other major illness that, in the investigator's judgment, will substantially
increase the risk associated with the participant's participation in this study

10. Use of other investigational drugs within 28 days or at least 5 half-lives (whichever
is shorter) before study drug administration

11. Prior exposure to drugs that are antagonists of colony stimulating factor-1 receptor
(CSF1R)

12. Use of any live vaccines (eg, intranasal influenza, measles, mumps, rubella, oral
polio, BCG, yellow fever, varicella, and TY21a typhoid vaccines) within 28 days

13. Prolongation of corrected QT [QTcF (Fridericia's corrected QT interval)] interval to
greater than 480 msec when electrolytes balance is normal

14. Significant cardiovascular impairment: history of congestive heart failure greater
than New York Heart Association (NYHA) Class II, uncontrolled arterial hypertension,
unstable angina, myocardial infarction, or stroke within 6 months of the first dose
of study drug; or cardiac arrhythmia requiring medical treatment (including oral
anticoagulation)

15. Females who are pregnant (positive urine test) or breastfeeding

16. Any history of a medical condition or a concomitant medical condition that, in the
opinion of the investigator, would compromise the participant's ability to safely
complete the study

Minimum Eligible Age: 18 Years

Maximum Eligible Age: 99 Years

Eligible Gender: Both