Inclusion Criteria:

          1. Female

          2. 18 years of age or older

          3. Scheduled to undergo non-nipple sparing mastectomy for Invasive Breast Cancer or DCIS
             within 1 month

          4. Pathological diagnosis of Invasive Ductal Breast Cancer or Ductal Carcinoma in Situ
             requiring mastectomy

          5. Estrogen Receptor-positive pathology

          6. ECOG performance scale of 0-1

          7. Adequate organ function as defined by the following criteria:

               -  Absolute neutrophil count (ANC) ≥ 1500/μl

               -  Platelets ≥ 100,000/μl

               -  Hemoglobin ≥ 9.0 g/dl

               -  Creatinine ≤ 2 times upper limit of normal

               -  Bilirubin ≤ 2 times upper limit of normal

               -  Transaminases (AST/SGOT and ALT/SGPT) ≤ 2.5 times upper limit of normal

          8. Able to sign informed consent

          9. Willing to use effective contraception for at least 28-days post study drug
             administration.

        Exclusion Criteria:

          1. Diagnosis of inflammatory breast carcinoma

          2. Concurrent treatment with another anti-estrogen

          3. Presence of an infection including ulcerations and fungal infections in the breast to
             be studied

          4. Any condition contraindicating fulvestrant administration:

               -  Subjects with bleeding diatheses, thrombocytopenia or current anticoagulant use

               -  Subjects with a known hypersensitivity to fulvestrant or any of its formulation
                  components including castor oil, alcohol, benzyl alcohol, and benzyl benzoate.

               -  Several hepatic impairments, define as Child-Pugh Class C or worse

          5. Prior breast surgery which interrupts communication of the ductal systems with the
             nipple

          6. Diagnosis of triple-negative or ER-negative breast cancer

          7. Non-Ductal Pathology: Lobular or Colloid type presence

          8. Subjects scheduled to undergo nipple sparing mastectomy

          9. Prior radiation to the breast or chest wall

         10. Pregnant or lactating

         11. Impaired renal function

         12. Impaired cardiac function or history of cardiac problems

         13. Poor nutritional state (as determined by clinician)

         14. Depressed bone marrow

         15. Presence of serious infection

         16. Presence of ascites (as determined by clinician)

         17. Presence of pleural effusion

         18. Allergies to Lidocaine or Novocain

         19. Allergies to imaging dyes