Inclusion Criteria:

          1. Chemotherapy refractory or relapsed CD133-positive liver cancer, pancreatic cancer,
             brain tumor ,breast cancer, ovarian tumors, colorectal cancer and acute leukemia.

          2. Patients must be 18 years of age or older.

          3. Patients must have an ECOG (Eastern Cooperative Oncology Group )performance status of
             0-2.

          4. Patients must have evidence of adequate bone marrow reserve, hepatic and renal
             function as evidenced by the following laboratory parameters:

             Absolute neutrophil count greater than 1500/mm3. Platelet count greater than
             100,000/mm3. Hemoglobin greater than 10g/dl (patients may receive transfusions to meet
             this parameter).

             Total bilirubin < 1.5 times upper limits of normal. Serum creatinine less than or
             equal to 1.6 mg/ml or the creatinine clearance must be greater than 70 ml/min/1.73m.

          5. Seronegative for HIV antibody.

          6. Seronegative for active hepatitis B, and seronegative for hepatitis C antibody.

          7. Patients must be willing to practice birth control during and for four months
             following treatment. NOTE: women of child-bearing age must have evidence of negative
             pregnancy test.

          8. Patients must be willing to sign an informed consent.

        Exclusion Criteria:

          -  1. Patients with life expectancy less than 12 months will be excluded. 2. Patients
             with uncontrolled hypertension (> 160/95), unstable coronary disease evidenced by
             uncontrolled arrhythmias, unstable angina, decompensated congestive heart failure (>
             New York Heart Association Class II), or myocardial infarction within 6 months of
             study will be excluded.

             3. Patients with any of the following pulmonary function abnormalities will be
             excluded: FEV(forced expiratory volume), < 30% predicted; DLCO (diffusing capacity of
             lung for carbon monoxide) < 30% predicted (post-bronchodilator); Oxygen Saturation
             less than 90% on room air.

             4. Patients with severe liver and kidney dysfunction or consciousness disorders will
             be excluded.

             5. Pregnant and/or lactating women will be excluded. 6. Patients with active
             infections, including HIV, will be excluded, due to unknown effects of the vaccine on
             lymphoid precursors.

             7. Patients with any type of primary immunodeficiencies will be excluded from the
             study.

             8. Patients requiring corticosteroids (other than inhaled) will be excluded. 9.
             Patients with history of T cell tumors will be excluded. 10. Patients who are
             participating or participated any other clinical trials in latest 30 days will be
             excluded.

             11. Patients with relapsed acute leukemia after allogeneic stem cell transplantation