Inclusion Criteria:

          1. Patients with bcr/abl-positive CML in stable cytogenetic / molecular remission after
             at least 18 months therapy with tyrosine kinase Inhibitors (TKI). The following groups
             of patients will be included:

               -  complete cytogenetic remission (CCyR), but stable detection of bcr/abl-transcript
                  on qPCR (at least on two different time points over a period of at least 6
                  months). A stable molecular remission is assumed, if the difference between the
                  qPCR values does not exceed a factor 5 (< 0,5log).

               -  No CCyR, but qPCR for bcr/abl transcript < 10% (= MCyR (Major cytogenetic
                  Response)) after at least 24 months on 2nd generation TKI therapy.

          2. Treatment with a TKI inhibitor and an additional anti leukemic drug is no exclusion
             criterion.

          3. Age 18-80 years

          4. Performance status of 0 or 1 according to WHO index or Karnofsky index >70 %

          5. Life expectancy > 18 months

          6. Hematological function should be at least partially conserved (platelets count
             >50.000/ μl, Hb > 8g/dl)

          7. written informed consent

          8. No breast feeding

          9. if of childbearing potential, negative pregnancy test (serum/urine ß- HCG ( human
             chorionic gonadotropin )) and willingness to use highly effective contraceptive
             methods (Pearl Index <1, e.g.: birth control pill, loop, hormone implant, transdermal
             hormone patch, a combination of two barrier methods [condom and vaginal diaphragm]
             sterilisation or sexual abstinence) for the study duration and thereafter as long as
             under treatment with antileukemic drugs

        Exclusion Criteria:

          1. Clinically relevant autoimmune disorders

          2. Immunodeficiency syndromes

          3. Known allergy to GM-CSF (granulocyte macrophage colony-stimulating factor), TNF-α
             (Tumor necrosis factor Alpha) , IL-4 (interleukine 4) or KLH (keyhole limpet
             hemocyanin)

          4. Pregnancy (absence confirmed by serum/urine ß-HCG) or breastfeeding

          5. Women of childbearing age without highly effective contraception

          6. Active infectious disease requiring treatment

          7. Continuous therapy with corticosteroids or other immunosuppressive drugs

          8. Severe psychiatric disorders

          9. Organ dysfunction:

               -  Thrombin Time / Partial Thromboplastin Time > 1,5 x upper normal limit

               -  creatinine > 2,0 mg/ml

               -  Bilirubin > 3,0 mg/ml, ALAT/ASAT (Alanine aminotransferase/ aspartate
                  aminotransferase) > 3x upper normal limit

               -  pulmonary disfunction (dyspnea at rest or with minimal exertion)

               -  clinically relevant coronary heart disease or ventricular arrhythmia, congestive
                  heart failure > grade II NYHA (New York Heart Association)

         10. Persons who are detained officially or legally to an official institute

         11. Subjects for whom there is concern about compliance with the protocol procedures

         12. Present History of substance abuse (drug or alcohol) or any other factor (e.g.,
             serious psychiatric condition) that could limit the subject's ability to comply with
             study procedures