Key Inclusion Criteria:

          -  Fully understand the study and voluntarily sign the informed consent form;

          -  At least 18 years old;

          -  Histologically or cytologically documented, locally advanced or metastatic solid
             malignancy of any type during the dose escalation phase, that has progressed on
             available standard systemic therapy, and for whom no effective therapy or standard of
             care exists; and locally advanced or metastatic BTC that has progressed on standard
             first-line chemotherapy; locally advanced or metastatic pNET that has progressed on
             everolimus, sunitinib or both; locally advanced or metastatic EP-NET that has
             progressed on everolimus; advanced STS that has progressed on at least one line of
             standard therapy or refused standard frontline cytotoxic chemotherapy during the
             expansion phase;

          -  Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

        Exclusion Criteria:

          -  Hypertension that is not controlled by antihypertension medication, defined as:
             systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg;

          -  History or presence of digestive tract diseases, including active gastric/duodenal
             ulcer or ulcerative colitis, or active hemorrhage of an unresected gastrointestinal
             tumor, or an evaluation by investigators of having any other condition that could
             possibly result in gastrointestinal tract hemorrhage or perforation;

          -  History or presence of serious hemorrhage , hemoptysis or hematemesis within 3 months
             or a thromboembolic event (including Deep Vein Thrombosis (DVT), stroke and/or
             transient ischemic attack) within 6 months;

          -  Patients with squamous Non Small Cell Lung Cancer (NSCLC) should be excluded;

          -  Clinically significant cardiovascular disease, including but not limited to, acute
             myocardial infarction within 6 months prior to enrollment, severe/unstable angina
             pectoris or coronary artery bypass grafting, New York Heart Association Class III/IV
             congestive heart failure, ventricular arrhythmias requiring treatment or left
             ventricular ejection fraction (LVEF) < 50%;

          -  Systemic anti-neoplastic therapies within 4 weeks prior to the initiation of
             investigational treatment, including chemotherapy, radical radiotherapy,
             hormonotherapy, biotherapy and immunotherapy;

          -  Palliative radiotherapy for bone metastasis/lesion within 2 weeks;

          -  Known Human immunodeficiency virus (HIV) infection;

          -  Known clinically significant history of liver disease, including viral or other
             hepatitis, current alcohol abuse, or cirrhosis;

          -  Women who are pregnant or lactating;

          -  Brain metastases and/or spinal cord compression untreated with surgery and/or
             radiotherapy, and without clinical imaging evidence of stable disease for 14 days or
             longer; Subjects requiring steroids within 4 weeks prior to start of study treatment
             will be excluded;

          -  Inability to take medication orally, dysphagia or an active gastric ulcer resulting
             from previous surgery or a severe gastrointestinal disease, or any other condition
             that investigators believe may affect absorption of the investigational product;

          -  Received investigational treatment in another clinical study within 4 weeks prior to
             the initiation of investigational treatment;

          -  Other disease, metabolic disorder, physical examination anomaly, abnormal laboratory
             result, or any other condition that investigators suspect may prohibit use of the
             investigational product, affect interpretation of study results, or put the patient at
             high risk.