Inclusion Criteria:

          -  ≥ 18 and ≤ 65 years

          -  Good performance status, ECOG 0 or 1 (39).

          -  Histologically proved adenocarcinoma in colon or rectum

          -  BRAF wild-type CRC on primary tumor or liver metastases

          -  High standard oncological surgical resection of the primary defined by :

               -  Safe margin of resection

               -  Curative resection of primary tumor according to oncological principles

               -  TNM adequate staging

          -  Absence of local recurrence on colonoscopy performed in the 12 months prior to
             inclusion (except in case of primary tumor resection < 12 months )

          -  Confirmed non resectable colorectal liver metastases by the validation committee

          -  ≥ 3 months of tumor control during the last chemotherapy line: Stable or Partial
             Response on RECIST criteria (40)

          -  ≤ 2 lines of chemotherapy for metastatic disease

          -  CEA < 80 microg/L or a decrease ≥ 50% of the highest serum CEA levels observed during
             the disease

          -  Absence of extrahepatic tumor localisation according to CT scan and PET-CT

          -  Renal function should be within the normal limits

          -  No need for extra-renal purification procedure, hemodialysis or kidney transplantation
             associated (nephrologist assessment)

          -  A platelet count> 80,000 / mm3

          -  White blood cell count> 2500 / mm3

          -  Eligible for both treatments groups

          -  Signed informed consent and expected cooperation of the patient for the treatment and
             follow up

        Exclusion Criteria:

          -  Participation refusal

          -  No health insurance facilities

          -  General contraindication to LT (Severe cardiopulmonary disease or other life-limiting
             coexisting medical conditions, extrahepatic malignancy, active alcohol or substance
             abuse, active infection or uncontrolled sepsis, lack of psychosocial support or
             inability to comply with medical treatment)

          -  Other malignancies either concomitant or within 5 years before liver transplantation

          -  Patients not having received standard treatment for the primary CRC according to
             recommended guidelines

          -  Prior extra hepatic metastatic disease or local relapse

          -  Pregnancy at the time of inclusion