Name | Type | Description | Interventions |
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Cohort 1A: Atezolizumab/Trastuzumab/Pertuzumab | Experimental | Participants will receive atezolizumab in combination with trastuzumab and pertuzumab every 3 weeks. | - Atezolizumab
- Pertuzumab
- Trastuzumab
|
Cohort 1B: Atezolizumab/Trastuzumab emtansine 3.6 mg | Experimental | Participants will receive atezolizumab in combination with trastuzumab emtansine (3.6 mg/kg) every 3 weeks. | - Atezolizumab
- Trastuzumab emtansine
|
Cohort 1C: Atezolizumab/Trastuzumab emtansine 3.0 mg | Experimental | Participants will receive atezolimumab in combination with trastzumab emtansine (3.0 mg/kg) every 3 weeks. | - Atezolizumab
- Trastuzumab emtansine
|
Cohort 1D: Atezolizumab/Trastuzumab emtansine 2.4 mg | Experimental | Participants will receive atezolimumab in combination with trastzumab emtansine (2.4 mg/kg) every 3 weeks. | - Atezolizumab
- Trastuzumab emtansine
|
Cohort 1E: Atezolizumab/ doxorubicin/ cyclophosphamide | Experimental | Participants with HER2-negative breast cancer will receive atezolizumab (every 2 weeks) in combination with doxorubicin (every 2 weeks) and cyclophosphamide for four cycles. After the completion of four cycles of combination atezolizumab /doxorubicin / cyclophosphamide, atezolizumab will be continued as a single-agent at a dose of 1200 mg every 3 weeks. | - Atezolizumab
- Doxorubicin
- Cyclophosphamide
|
Cohort 1F: Atezolizumab/Trastuzumab/Pertuzumab/ Docetaxel | Experimental | Participants will receive atezolizumab in combination with trastuzumab, pertuzumab, and docetaxel every 3 weeks. | - Atezolizumab
- Docetaxel
- Pertuzumab
- Trastuzumab
|
Cohort 2A: Atezolizumab/Trastuzumab/Pertuzumab | Experimental | Participants will receive atezolizumab in combination with trastuzumab and pertuzumab every 3 weeks for 2 cycles, followed by docetaxel, carboplatin, trastuzumab and pertuzumab every 3 weeks for 6 cycles. Breast surgery will be performed no later than 6 weeks after neoadjuvant therapy. Upon the completion of surgery, participants will receive 12 cycles of single-agent trastuzumab every 3 weeks. | - Atezolizumab
- Carboplatin
- Docetaxel
- Pertuzumab
- Trastuzumab
|
Cohort 2B: Atezolizumab/Trastuzumab emtansine | Experimental | Participants will receive atezolizumab in combination with trastuzumab emtansine every 3 weeks for 2 cycles, followed by docetaxel, carboplatin, trastuzumab and pertuzumab every 3 weeks for 6 cycles. Breast surgery will be performed no later than 6 weeks after neoadjuvant therapy. Upon the completion of surgery, participants will receive 12 cycles of single-agent trastuzumab every 3 weeks. | - Atezolizumab
- Carboplatin
- Docetaxel
- Pertuzumab
- Trastuzumab
- Trastuzumab emtansine
|
Cohort 2C: Safety Expansion | Experimental | Participants with HER2-positive metastatic breast cancer/unresectable locally advanced breast cancer who received prior treatment with trastuzumab and a taxane chemotherapy will receive atezolizumab in combination with trastuzumab emtansine at the dose determined from stage 1, every 3 weeks until disease progression, lack of clinical benefit, or unacceptable toxicity. | - Atezolizumab
- Trastuzumab emtansine
|
Cohort 2D: Safety Expansion | Experimental | Participants with HER2-positive metastatic breast cancer recently progressed on an HP containing regimen will receive atezolimumab in combination with trastuzumab and pertuzumab every 3 weeks until disease progression, lack of clinical benefit, or unacceptable toxicity. | - Atezolizumab
- Pertuzumab
- Trastuzumab
|