Inclusion Criteria:

          1. Solid tumor specific:

               -  Patients must have a histologically/cytologically confirmed primary solid tumor

               -  Radiographic or clinical evidence of advanced/metastatic malignant disease that
                  is resistant to standard therapy or for which no standard therapy is available.
                  Lesions may be measurable or non-measurable

          2. Multiple myeloma specific:

               -  Confirmed evidence of disease progression from immediately prior MM therapy or
                  refractory to the immediately prior treatment

               -  Measurable disease M protein component in serum (at least 0.5 g/dL) and/or urine
                  (if present), (>=0.2 g excreted in a 24 hour collection sample).

               -  Subjects with free light chain only disease are excluded

          3. All previous therapies for cancer, including radiotherapy, major surgery and
             investigational therapies discontinued for ≥ 14 days (≥ 28 days for mitomycin C or
             nitrosoureas ) before Cycle 1 Day 1 (C1D1), and all acute effects of any prior therapy
             resolved to baseline severity or Grade ≤ 1 Common Terminology Criteria for Adverse
             Events (CTCAE v4.03), except alopecia or parameters defined in this eligibility list

          4. Age ≥ 18 years

          5. ECOG performance status ≤ 1

          6. Adequate organ and marrow function as defined below:

               -  Absolute neutrophil count ≥1,000/mm3 without growth factor use ≤ 7 days prior to
                  C1D1

               -  Platelets ≥75,000/mm3 without platelet transfusion ≤ 7 days prior to C1D1

               -  Hemoglobin >8.0 mg/dL without red blood cell transfusion ≤ 7 days prior to C1D1

               -  Total serum bilirubin <1.5 X upper limit of normal (ULN)

               -  AST (SGOT)/ALT (SGPT) ≤2 X ULN; ≤ 5 X ULN if there is liver involvement secondary
                  to tumor

               -  Serum creatinine ≤ 1.5 X ULN (OR creatinine clearance ≥ 60 mL/min/1.73 m2)

               -  Serum or urine pregnancy test (for females of childbearing potential) negative ≤7
                  days of starting treatment

          7. Ability to understand and the willingness to sign a written informed consent document
             and comply with the study scheduled visits, treatment plans, laboratory tests and
             other procedures.

          8. Female patients must be surgically sterile or be postmenopausal, or must agree to use
             effective contraception during the period of the trial and for at least 90 days after
             completion of treatment. Male patients must be surgically sterile or must agree to use
             effective contraception during the period of the trial and for at least 90 days after
             completion of treatment. The decision of effective contraception will be based on the
             judgment of the principal investigator or a designated associate.

        Exclusion Criteria:

          1. Patients with symptomatic brain metastases are excluded. Patients with asymptomatic
             and treated CNS metastases may participate in this trial. The patient must have
             completed any prior treatment for CNS metastases > 28 days prior to study entry
             including radiotherapy or surgery. Steroids for the treatment of brain metastasis are
             not permitted.

          2. Active inflammatory gastrointestinal disease, chronic diarrhea (unless related to
             underlying malignancy or prior related treatment) or history of abdominal fistula,
             gastrointestinal perforation, peptic ulcer disease, or intra-abdominal abscess within
             6 months prior to study enrollment. Gastroesophageal reflux disease under treatment
             with proton pump inhibitors is allowed.

          3. Pregnancy or breast feeding

          4. Current active treatment in another clinical study

          5. Active bacterial, fungal or viral infection including hepatitis B (HBV), hepatitis C
             (HCV), requiring treatment with IV antibiotic, IV anti-fungal, or anti-viral.

          6. Known human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome
             (AIDS)-related illness.

          7. Multiple myeloma specific:

               -  Active or prior plasma cell leukemia (defined as either 20% of peripheral WBC
                  comprised of plasma/CD138+ cells or an absolute count of 2 x 10^9/L)

               -  Solitary bone or solitary extramedullary plasmacytoma as the only evidence of
                  plasma cell dyscrasia.

          8. Subjects with serum calcium (corrected for albumin) ≥ 12 mg/dL

          9. Any of the following in the previous 6 months: myocardial infarction, severe/unstable
             angina, coronary/peripheral artery bypass graft, symptomatic congestive heart failure,
             cerebrovascular accident, transient ischemic attack or symptomatic pulmonary embolism.

         10. Other severe acute or chronic medical or psychiatric condition or laboratory
             abnormality that may increase the risk associated with study participation or study
             drug administration, or may interfere with the interpretation of study results, or in
             the judgment of the investigator would make the patient inappropriate for entry into
             the study.