Clinical Trials /

Nintedanib+Letrozole in Postmenopausal Women With Breast Cancer: Clinical Trial Safety and Pharmacodynamics

NCT02619162

Description:

Open, multicenter phase I with gradual increase in dosage to evaluate the safety and tolerability of orally administered nintedanib plus letrozole orally (2.5 mg / day) for patients with breast cancer. Nintedanib is administered twice a day orally for 28 consecutive days (Days 1-28) in 4-week cycles.

Related Conditions:
  • Breast Carcinoma
Recruiting Status:

Unknown status

Phase:

Phase 1

Trial Eligibility

Document

Title

  • Brief Title: Nintedanib+Letrozole in Postmenopausal Women With Breast Cancer: Clinical Trial Safety and Pharmacodynamics
  • Official Title: Nintedanib Plus Letrozole in Postmenopausal Women With Breast Cancer: Clinical Trial Phase 0/1 Safety and Pharmacodynamics

Clinical Trial IDs

  • ORG STUDY ID: CNIO-BR-007
  • NCT ID: NCT02619162

Conditions

  • Breast Cancer

Interventions

DrugSynonymsArms
NintedanibBIFF 1120Letrozole+Nintedanib
LetrozoleLetrozole+Nintedanib

Purpose

Open, multicenter phase I with gradual increase in dosage to evaluate the safety and tolerability of orally administered nintedanib plus letrozole orally (2.5 mg / day) for patients with breast cancer. Nintedanib is administered twice a day orally for 28 consecutive days (Days 1-28) in 4-week cycles.

Detailed Description

      Phase 0 / I:

      At level 1 it includes three patients. If any patient suffers dose limiting toxicity (DLT),
      it proceeds to the increase in dose to the next level. If 2/3 patients experience DLT, he
      will close the increased dose and extended / investigate the previous dose level with 3
      additional patients.

      If the level 2, but less than 1/3 the minimum of 6 patients experience TLD is reached, the
      phase I be suspended because not expected another rise above Level 2.

      Dose levels:

        -  Level 1: Nintedanib 150 mg twice daily + oral letrozole 2.5 mg / day orally, in a cycle
           of 28 days.

        -  Level 2: Nintedanib 200 mg twice daily via oral + letrozole 2.5 mg / day orally, in a
           cycle of 28 days.

        -  At least the first cycle will be administered during Phase I. A total of six four-week
           cycles were administered at the discretion of the investigator.
    

Trial Arms

NameTypeDescriptionInterventions
Letrozole+NintedanibExperimentalLetrozole+Nintedanib
  • Nintedanib
  • Letrozole

Eligibility Criteria

        Inclusion Criteria:

          1. Form signed informed consent.

          2. Women ≥ 18 years.

          3. Confirmed diagnosis of invasive non-metastatic breast cancer positive for hormone
             receptors. The inclusion of patients with ductal or lobular histology allowed.

          4. Size greater than 1 cm tumor and any N or N ≥ 1 and any T, including inflammatory
             breast cancer.

          5. Absence of metastatic involvement.

          6. Postmenopausal state. Postmenopausal status is defined as more than 24 months after
             the last menstrual period, or previous known ovariectomy, or chemical, determined by
             FSH, LH and estradiol 17-B according to the local laboratory values over 12 months
             without menstruation.

          7. ECOG performance status of 0 or 1

          8. At least one month after the end of radiotherapy and / or chemotherapy.

          9. At least 6 weeks since major surgery.

         10. Patients currently treated with letrozole less than 6 months.

         11. Primary surgery for breast cancer already done. The elderly women with advanced local
             or regional tumors in which hormone treatment is administered as monotherapy,
             regardless of the intent of the surgery are not candidates.

         12. LVEF> 50%

         13. Renal function, liver and adequate hematologic, defined by the following analytical
             results within 14 days prior to randomization or registration:

               -  Absolute granulocyte count> 1.5 x 109 / L

               -  Absolute platelet count> 100 x 109 / L

               -  Hemoglobin> 10 g / dl

               -  Serum creatinine ≤ 1.5 x ULN or calculated creatinine clearance> 50 ml / min

               -  Serum bilirubin <1.25 ULN

               -  AST / ALT ≤ 1.5 times the LS

         14. Toxicities associated with chemotherapy recovery lesser extent 2 not tolerable.

         15. Life expectancy> 6 months.

        Exclusion Criteria:

          1. HER2 overexpression defined as positive by immunohistochemistry HER-2-positive 2+ 3+
             or FISH / CISH.

          2. Absence of tumor tissue file.

          3. T1 N0 stage patients are excluded.

          4. Malignancy concomitant active, or diagnosis of another malignancy within the last five
             years, apart from non-melanoma or ductal / tubular breast carcinoma skin cancer (not
             received hormone treatment) or in situ cervical cancer, carcinoma colon in situ
             treated properly, as well as any diagnosis of tumor less than five years before the
             inclusion unsigned progression today.

          5. Women of childbearing potential.

          6. Pretreatment nintedanib. Use of other investigational drugs during the administration
             of adjuvant or neoadjuvant treatment is not an exclusion criterion as long as toxicity
             recovers.

          7. Medical Condition concomitant serious, like eg myocardial infarction within 6
             uncontrolled prior to inclusion in the study months, congestive heart failure,
             unstable angina, cardiomyopathy active, unstable ventricular arrhythmia, hypertension
             (according to the criteria of the NYHA) , psychotic disorders uncontrolled severe
             active infections, active peptic ulcer disease, psychiatric disease, HIV infection,
             active hepatitis, COPD or any other medical condition that might be aggravated by
             treatment or limits compliance.

          8. Inability to make oral, or history of malabsorption syndrome medication.

          9. Failure to comply with the study and follow-up procedures.

         10. Anticoagulant therapy (except low-dose heparin or heparin washing as needed to
             maintain a permanent intravenous device) or antiplatelet therapy (except low-dose
             therapy with aspirin, less than 325 mg daily).

         11. History of thromboembolic or hemorrhagic episodes that are clinically relevant in the
             past 6 months or hereditary predisposition to bleeding or thrombosis.

         12. Contraindication to hormonal blockade or absence of hormone-blocking prescription from
             your doctor for any reason. Metastatic breast cancer or non-surgical (including
             inflammatory).
      
Maximum Eligible Age:N/A
Minimum Eligible Age:18 Years
Eligible Gender:Female
Healthy Volunteers:No

Primary Outcome Measures

Measure:Dose limiting toxicity
Time Frame:1-6 months
Safety Issue:
Description:Classified according to the version 4.03 of CTCAE criteria NCI1

Secondary Outcome Measures

Measure:Evaluating FGFR1 modulation and inhibition levels of 17-B Estradiol
Time Frame:1-6 months
Safety Issue:
Description:Assess the pharmacodynamic modulation of FGFR1 and inhibition levels of 17-B: determine plasma levels of FGF 23 ang 17- B estradiol (pg/mL)
Measure:Pharmacokinetic interactions
Time Frame:29 days
Safety Issue:
Description:Determine the pharmacokinetic interactions nintedanib combined with letrozole: determine plasma levels of Nintedanib and Letrozole at day 0, day 15 and day 29 (Cmax)

Details

Phase:Phase 1
Primary Purpose:Interventional
Overall Status:Recruiting
Lead Sponsor:Centro Nacional de Investigaciones Oncologicas CARLOS III

Trial Keywords

  • breast cancer non metastatic
  • adjuvant letrozole
  • Nintedanib BIFF1120

Last Updated

September 13, 2017