Inclusion Criteria:

          1. Must be competent and able to comprehend, sign, and date an Ethics Committee (EC) or
             Institutional Review Board approved Informed Consent Form (ICF) before performance of
             any study-specific procedures or tests;

          2. Is ≥18 years or the minimum legal adult age (whichever is greater) and ≤75 years (at
             Screening);

          3. Newly diagnosed, morphologically documented primary AML or AML secondary to
             myelodysplastic syndrome or a myeloproliferative neoplasm, based on the World Health
             Organization (WHO) 2008 classification (at Screening);

          4. Eastern Cooperative Oncology Group (ECOG) performance status 0-2 (at the time the
             participant signs their first ICF);

          5. Presence of FLT3-ITD activating mutation in bone marrow (allelic ratio of ≥3%
             FLT3-ITD/total FLT3);

          6. Participant is receiving standard "7+3" induction chemotherapy regimen as specified in
             the protocol;

          7. Adequate renal function defined as:

             a. Creatinine clearance >50 mL/min, as calculated with the modified Cockcroft Gault
             equation

          8. Adequate hepatic function defined as:

               1. Total serum bilirubin (TBL) ≤1.5 × upper limit of normal (ULN) unless the
                  participant has documented Gilbert's syndrome or the increase is related to
                  increased unconjugated (indirect) bilirubin due to hemolysis;

               2. Serum alkaline phosphatase, aspartate transaminase (AST) and alanine transaminase
                  (ALT) ≤2.5 × ULN;

          9. Serum electrolytes within normal limits: potassium, calcium (total, or corrected for
             serum albumin in case of hypoalbuminemia or ionized calcium) and magnesium. If outside
             of normal limits, participant will be eligible when electrolytes are corrected;

         10. If a woman of childbearing potential, must have a negative serum pregnancy test upon
             entry into this study and must be willing to use highly effective birth control upon
             enrollment, during the treatment period and for 6 months following the last dose of
             investigational drug or cytarabine, whichever is later. A woman is considered of
             childbearing potential following menarche and until becoming postmenopausal (no
             menstrual period for a minimum of 12 months);

         11. If male, must be surgically sterile or willing to use highly effective birth control
             upon enrollment, during the treatment period, and for 6 months following the last dose
             of investigational drug or cytarabine, whichever is later.

        Exclusion Criteria:

          1. Diagnosis of acute promyelocytic leukemia (APL), French-American-British
             classification M3 or WHO classification of APL with translocation, t(15;17)(q22;q12),
             or breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1
             (BCR-ABL) positive leukemia (ie, chronic myelogenous leukemia in blast crisis);
             participants who undergo diagnostic workup for APL and treatment with all-trans
             retinoic acid (ATRA), but who are found not to have APL, are eligible (treatment with
             ATRA must be discontinued before starting induction chemotherapy).

          2. Diagnosis of AML secondary to prior chemotherapy or radiotherapy for other neoplasms;

          3. Prior treatment for AML, except for the following allowances:

               -  Leukapheresis;

               -  Treatment for hyperleukocytosis with hydroxyurea;

               -  Cranial radiotherapy for central nervous system (CNS) leukostasis;

               -  Prophylactic intrathecal chemotherapy;

               -  Growth factor/cytokine support;

          4. Prior treatment with quizartinib or other FLT3-ITD inhibitors;

          5. Prior treatment with any investigational drug or device within 30 days prior to
             Randomization (within 2 weeks for investigational or approved immunotherapy) or
             currently participating in other investigational procedures;

          6. History of known CNS leukemia, including cerebrospinal fluid positive for AML blasts;
             lumbar puncture is recommended for participants with symptoms of CNS leukemia to rule
             out extramedullary CNS involvement;

          7. History of other malignancies, except adequately treated non-melanoma skin cancer,
             curatively treated in-situ disease, or other solid tumors curatively treated with no
             evidence of disease for at least 2 years;

          8. Uncontrolled or significant cardiovascular disease, including any of the following:

               -  Bradycardia of less than 50 beats per minute, unless the participant has a
                  pacemaker;

               -  Fridericia's Heart Rate Correction Formula (QTcF) interval >450 msec;

               -  Diagnosis of or suspicion of long QT syndrome (including family history of long
                  QT syndrome);

               -  Systolic blood pressure ≥180 mmHg or diastolic blood pressure ≥110 mmHg;

               -  History of clinically relevant ventricular arrhythmias (eg, ventricular
                  tachycardia, ventricular fibrillation, or Torsade de Pointes);

               -  History of second (Mobitz II) or third degree heart block (participants with
                  pacemakers are eligible if they have no history of fainting or clinically
                  relevant arrhythmias while using the pacemaker);

               -  History of uncontrolled angina pectoris or myocardial infarction within 6 months
                  prior to Screening;

               -  History of New York Heart Association Class 3 or 4 heart failure;

               -  Known history of left ventricular ejection fraction (LVEF) ≤45% or less than the
                  institutional lower limit of normal;

               -  Complete left bundle branch block;

          9. Active acute or chronic systemic fungal, bacterial, or viral infection not well
             controlled by antifungal, antibacterial or antiviral therapy;

         10. Known active clinically relevant liver disease (eg, active hepatitis B, or active
             hepatitis C);

         11. Known history of human immunodeficiency virus (HIV). Participants should be tested for
             HIV prior to Randomization if required by local regulations or EC;

         12. History of hypersensitivity to any excipients in the quizartinib/placebo tablets;

         13. Females who are pregnant or breastfeeding;

         14. Otherwise considered inappropriate for the study by the Investigator.