Inclusion Criteria:

          -  ECOG ≤ 1

          -  Willing to undergo tumor biopsies from injected and distal lesions

          -  Must have two biopsy accessible lesions:

               -  * one lesion must be ≥10 mm and <100 mm in longest diameter, accessible for
                  repeated intratumoral (IT) injection and accessible for baseline and on-treatment
                  biopsies.

                    -  a second (distal) lesion must be accessible for baseline and on-treatment
                       biopsy and must be distinct from the injected lesion.

                    -  tumors encasing major vascular structures (i.e., carotid artery or tumors
                       close to other vital organs), are not considered appropriate

        Exclusion Criteria:

          -  Patients who require local palliative measures such as XRT or surgery

          -  Symptomatic or untreated leptomeningeal disease.

          -  Presence of symptomatic central nervous system (CNS) metastases

          -  Impaired cardiac function or clinically significant cardiac disease

          -  Active autoimmune disease or a documented history of autoimmune disease, except
             vitiligo or resolved childhood asthma/atopy.

          -  Active infection requiring systemic antibiotic therapy.

          -  Known history of Human Immunodeficiency Virus (HIV) infection.

          -  Active Epstein-Barr virus (EBV), hepatitis B virus (HBV) or hepatitis C virus (HCV)

          -  Malignant disease, other than that being treated in this study.