Inclusion Criteria:

          1. Subjects with confirmed diagnosis of Mantle Cell Lymphoma (World Health Organization
             Classification, WHO 2008). Classical, small-cell variants and marginal-zone variants
             can be included.

          2. Age 18 years or older.

          3. Subjects must not have received any prior therapies (excluding diagnostic
             splenectomy).

          4. Asymptomatic patients.

          5. Ann Arbor clinical stages I-IV.

          6. Eastern Cooperative Oncology Group (ECOG) performance status <2 (0-1).

          7. Subjects with a non-nodal MCL presentation with mainly bone marrow or peripheral blood
             involvement.

          8. Other asymptomatic clinical presentations are acceptable in case of low tumor burden,
             including nodal MCL with lymph node enlargement ≤3 cm in the maximum diameter and with
             low proliferation index (Ki-67 ≤ 30%).

          9. The following laboratory values at screening: a) Neutrophil count ≥ 1×10e9/L,
             Hemoglobin level ≥ 100 g/L or platelet count ≥100×10e9/L; b) Transaminases (AST and
             ALT) ≤ 3 x ULN. c)Total bilirubin ≤1.5 x ULN unless bilirubin rise is due to Gilbert's
             syndrome or of non-hepatic origin; d) Creatinine ≤ 2 x ULN or calculated creatinine
             clearance ≥ 40 mL/min/1.73 m2.

         10. Stable disease without evidence of clinical progression criteria for at least 3
             months. Patients in prolonged therapeutic abstention may be included.

         11. Women of childbearing potential and men who are sexually active must be practising a
             highly effective method of birth control during and after the study consistent with
             local regulations regarding the use of birth control methods for subjects
             participating in clinical trials. Men must agree to not donate sperm during and after
             the study. For females, these restrictions apply for 1 month after the last dose of
             study drug. For males, these restrictions apply for 3 months after the last dose of
             study drug.

         12. Women of childbearing potential must have a negative serum (beta-human chorionic
             gonadotropin [-hCG]) or urine pregnancy test at Screening. Women who are pregnant or
             breastfeeding are ineligible for this study.

         13. Sign (or their legally-acceptable representatives must sign) an informed consent
             document indicating that they understand the purpose of and procedures required for
             the study, including biomarkers, and are willing to participate in the study.

        Exclusion Criteria:

          1. Aggressive histological variants: blastic and pleomorphic variants (blastoid).

          2. Proliferation index measured by Ki-67 > 30%.

          3. B-cell monoclonal lymphocytosis with MCL phenotype

          4. Eastern Cooperative Oncology Group (ECOG) performance status ≥2. Presence of B
             symptoms or any relevant symptoms related to the MCL.

        6. Nodal clinical forms with lymph node enlargement >3 cm (maximum diameter). 7. Cytopenias
        attributable to MCL: Neutrophil count < 1×10e9/L, Hemoglobin level < 100 g/L or platelet
        count < 100×10e9/L.

        8. Organ dysfunction related to MCL including creatinine level > 2 x ULN or altered liver
        biochemistry (> 3x ULN).

        9. Gradual increase in different determinations of serum LDH attributable to MCL that
        exceeds 20% of the ULN.

        10. Known CNS infiltration. 11. Subjects with expected therapy requirement for MCL in a
        short time (< 3 months) 12. Patients with active hepatitis B or C infection or HIV
        infection. Positive test results for chronic HBV infection (defined as positive HBsAg
        serology) or positive test results for hepatitis C (hepatitis C virus [HCV] antibody
        serology testing) will be excluded with the following exceptions. Patients with occult or
        prior HBV infection (defined as negative HBsAg and positive total HBcAb) may be included if
        HBV DNA is undetectable, provided that they are willing to undergo monthly DNA testing or
        antiviral prophylaxis. Patients who have protective titers of hepatitis B surface antibody
        (HBsAb) after vaccination or prior but cured hepatitis B are eligible. Patients positive
        for HCV antibody are eligible only if PCR is negative for HCV RNA.

        13. Anticoagulation requirement with vitamin K antagonists. 14. Past medical history of
        stroke or intracranial haemorrhage within 6 months prior to inclusion.

        15. Required medication with strong CYP3A4/5 inhibitors 16. Any serious comorbidity that
        makes the patient unacceptable for receiving the treatment.

        17. Concomitant or previous malignancies the last 2 years other than basal skin cancer or
        in situ uterine cervix cancer.

        18. Pregnancy or lactation. 19. Major surgery within 4 weeks of inclusion. 20. Clinically
        significant cardiovascular disease such as uncontrolled or symptomatic arrhythmias,
        congestive heart failure, or myocardial infarction within 6 months of Screening, or any
        Class 3 (moderate) or Class 4 (severe) cardiac disease as defined by the New York Heart
        Association Functional Classification.

        21. Vaccinated with live, attenuated vaccines within 4 weeks of randomization. 22.
        Uncontrolled systemic infection requiring intravenous (IV) antibiotics. 23. Any
        life-threatening illness, medical condition, or organ system dysfunction which, in the
        investigator's opinion, could compromise the subject's safety, interfere with the
        absorption or metabolism of ibrutinib capsules, or put the study outcomes at undue risk.