Inclusion Criteria:

          -  Patient (male or female) ≥12 years of age

          -  ECOG (Eastern Cooperative Oncology Group) performance status ≤1

          -  Must have progressed following standard therapy, or for whom, in the opinion of the
             Investigator, no effective standard therapy exists, is tolerated or appropriate.

          -  Patients must be willing and able to undergo study required biopsies.

          -  Presence of at least one measurable lesion according to RECIST v1.1.

          -  Documented MAPK pathway alteration

        Exclusion Criteria:

          -  Prior treatment with ERK inhibitors.

          -  History or current evidence of retinal vein occlusion (RVO) or current risk factors
             for RVO.

          -  Any medical condition that would, in the investigator's judgment, prevent the
             patient's participation in the clinical study due to safety concerns or compliance
             with clinical study procedures.

          -  Patients receiving proton pump inhibitors (PPI) which cannot be discontinued 3 days
             prior to the start study treatment and for the duration of the study.

          -  Patients with malignant disease other than that being treated in the study.

          -  Clinically significant cardiac disease.

        Other protocol-defined exclusion criteria may apply.