Inclusion criteria. Patients may be entered in the study only if they meet all of the
        following criteria:

        1. Adults at least 18 years of age. 2. Eastern Cooperative Oncology Group (ECOG)
        performance status ≤1. 3.

          1. Subjects with histopathologically or cytologically confirmed diagnosis of non-uveal
             Melanoma, RCC or NSCLC, for whom the use of nivolumab is indicated. NSCLC subjects
             with EGFR or ALK genomic aberrations in tumor should have disease progression on
             FDA-approved therapy for these aberrations prior to receiving nivolumab (Phase 1b).

          2. Subjects with histopathologically or cytologically confirmed diagnosis of non-uveal
             Melanoma, or NSCLC, for whom the use of nivolumab is indicated. With Protocol
             Amendment 5, subjects with NSCLC are not eligible for enrollment.

          3. Non-uveal melanoma and NSCLC patients whose disease has progressed after achieving SD
             for at least 3 months, PR or CR as the best response that has been documented by
             imaging studies (Phase 2 expansion).With Protocol Amendment 5, subjects with NSCLC are
             not eligible for enrollment.

             4. Subject must have at least one measurable target lesion as defined by Response
             Evaluation Criteria in Solid Tumors (RECIST) v.1.1. Melanoma subjects participating in
             the optional serial tumor biopsy sub-study must have tumor tissue available from a
             metastatic or unresectable site for PD-L1 and correlative biomarker analysis.

             5. All prior systemic therapy (chemotherapy, mutation targeting therapy, immune
             checkpoint therapy), surgical or radiation treatment must have been completed at least
             4 weeks before study drug administration (2 weeks for palliative radiotherapy, 1 week
             for minor surgery) pending full recovery from therapy.

             6. The following laboratory results within 7 days prior to study drug administration:
             Adequate hematopoietic, electrolyte, hepatic, and renal laboratory findings as defined
             below: WBC ≥3000/μL, Neutrophils ≥1500/μL, Platelets ≥100x103/μL, Hemoglobin ≥9.0g/dL
             independent of transfusion, Creatinine ≤1.5mg/dL, AST and ALT ≤3x ULN, Alkaline
             phosphatase ≤2.5x ULN unless bone metastases present, Bilirubin ≤1.5x ULN (unless
             known Gilbert's disease where it must be ≤3x ULN) and serum albumin ≥3.0g/dL.

             7. Life expectancy ≥12 weeks. 8. A negative serum pregnancy test at baseline for women
             of childbearing potential.

             9. Are willing to abstain from heterosexual activity or practice physical barrier
             contraception prior to time of study entry to at least 5 months after the last day of
             treatment.

             10. Have the ability to understand and the willingness to sign a written informed
             consent document.

             Exclusion criteria. Subjects who fulfill any of the following criteria at screening
             will not be eligible for admission into the study:

               1. History of Grade 3 or above hypersensitivity reactions to other monoclonal
                  antibodies.

               2. Subjects with a history of a cardiovascular illness including: congestive heart
                  failure (New York Heart Association Grade III or IV); unstable angina or
                  myocardial infarction within the previous 6 months; or symptomatic cardiac
                  arrhythmia despite medical management.

               3. Uncontrolled hypertension, SBP >160 or DBP >100.

               4. Subjects with active brain metastasis; previously treated brain metastasis is
                  allowed if it has been stable for 4 weeks or more and not requiring steroids.

               5. Presence of leptomeningeal disease.

               6. History of hemorrhagic diarrhea, inflammatory bowel disease, active uncontrolled
                  peptic ulcer disease or recurrent pleural effusion requiring repetitive
                  palliative thoracentesis within 3 months prior to study entry, except for
                  subjects with a pleurex port. and immune-mediated toxicity leading to treatment
                  discontinuation

               7. Active, known, or suspected autoimmune disease, except for type I diabetes
                  mellitus, hypothyroidism only requiring hormone replacement, skin disorders (such
                  as vitiligo, psoriasis, or alopecia).

               8. Active uncontrolled bacterial, viral, or fungal infection requiring systemic
                  therapy.

               9. Known history of testing positive for human immunodeficiency virus (HIV), known
                  acquired immunodeficiency syndrome (AIDS).

              10. Active hepatitis B (serum hepatitis B surface antigen [HBV sAg] positive), or
                  hepatitis C (HCV antibody test or serum hepatitis C RNA positive) indicating
                  acute or chronic infection.

              11. Subjects with a condition requiring systemic treatment with either
                  corticosteroids (>10mg daily prednisone equivalents) or other immunosuppressive
                  medications within 14 days of study drug administration. Inhaled or topical
                  steroids are permitted.

              12. Use of other investigational agent (drug not marketed for any indication) within
                  28 days or at least 5 half-lives (whichever is shorter) before study drug
                  administration.

              13. Pregnant or breast-feeding women.

              14. Second malignancy unless in remission for 2 years, except for non-melanomatous
                  skin cancer, carcinoma in situ of the cervix treated with curative intent,
                  curatively treated prostate cancer with prostate-specific antigen (PSA) <0.1
                  ng/mL.

              15. Underlying medical conditions that, in the Investigator's opinion, will make the
                  administration of study drug hazardous or obscure the interpretation of toxicity
                  determination or adverse events.

              16. Unwilling or unable to comply with procedures required in this protocol.