Name | Type | Description | Interventions |
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Part A: Favezelimab Dose A | Experimental | Participants receive favezelimab Dose A intravenous (IV) infusion on Day 1 of each 21-day cycle. | |
Part A: Favezelimab Dose B | Experimental | Participants receive favezelimab Dose B IV infusion on Day 1 of each 21-day cycle. | |
Part A: Favezelimab Dose C | Experimental | Participants receive favezelimab Dose C IV infusion on Day 1 of each 21-day cycle. | |
Part A: Favezelimab Dose D | Experimental | Participants receive favezelimab Dose D IV infusion on Day 1 of each 21-day cycle. | |
Part A: Favezelimab Dose E | Experimental | Participants receive favezelimab Dose E IV infusion on Day 1 of each 21-day cycle. | |
Part A: Favezelimab Dose A+Pembro | Experimental | Participants receive favezelimab Dose A IV infusion on Day 1 of each 21-day cycle PLUS pembrolizumab IV infusion administered sequentially on Day 1 of each 21-day cycle. | |
Part A: Favezelimab Dose B+Pembro | Experimental | Participants receive favezelimab Dose B IV infusion on Day 1 of each 21-day cycle PLUS pembrolizumab IV infusion administered sequentially on Day 1 of each 21-day cycle. | |
Part A: Favezelimab Dose C+Pembro | Experimental | Participants receive favezelimab Dose C IV infusion on Day 1 of each 21-day cycle PLUS pembrolizumab IV infusion administered sequentially on Day 1 of each 21-day cycle. | |
Part A: Favezelimab Dose D+Pembro | Experimental | Participants receive favezelimab Dose D IV infusion on Day 1 of each 21-day cycle PLUS pembrolizumab IV infusion administered sequentially on Day 1 of each 21-day cycle. | |
Part A: Favezelimab Dose E+Pembro | Experimental | Participants receive favezelimab Dose E IV infusion on Day 1 of each 21-day cycle PLUS pembrolizumab IV infusion administered sequentially on Day 1 of each 21-day cycle. | |
Part B: Favezelimab Monotherapy Dose | Experimental | Participants receive favezelimab monotherapy dose IV infusion on Day 1 of each 21-day cycle. | |
Part B: Favezelimab Dose F+Pembro | Experimental | Participants receive favezelimab Dose F IV infusion on Day 1 of each 21-day cycle PLUS pembrolizumab IV infusion administered sequentially on Day 1 of each 21-day cycle. | |
Part B: Favezelimab Dose G+Pembro | Experimental | Participants receive favezelimab Dose G IV infusion on Day 1 of each 21-day cycle PLUS pembrolizumab IV infusion administered sequentially on Day 1 of each 21-day cycle. | |
Part B: Favezelimab Dose H+Pembro | Experimental | Participants receive favezelimab Dose H IV infusion on Day 1 of each 21-day cycle PLUS pembrolizumab IV infusion administered sequentially on Day 1 of each 21-day cycle. | |
Part B: Favezelimab Dose G+Pembro+mFOLFOX7 | Experimental | Participants receive favezelimab Dose G IV infusion on Day 1 of each 21-day cycle PLUS pembrolizumab IV infusion administered sequentially on Day 1 of each 21-day cycle PLUS mFOLFOX7 (oxaliplatin 85 mg/m^2 IV, leucovorin [calcium folinate] 400 mg/m^2 IV and fluorouracil [5-FU] 2400 mg/m^2 IV over 46 to 48 hours every 2 weeks [Q2W]). | - Favezelimab
- Pembrolizumab
- Oxaliplatin
- Leucovorin (Calcium Folinate)
- Fluorouracil [5-FU]
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Part B: Favezelimab Dose G+Pembro+FOLFIRI | Experimental | Participants receive favezelimab Dose G IV infusion on Day 1 of each 21-day cycle PLUS pembrolizumab IV administered sequentially on Day 1 of each 21-day cycle PLUS FOLFIRI (irinotecan 180 mg/m^2 IV, leucovorin [calcium folinate] 400 mg/m^2 IV and 5-FU 2400 mg/m^2 IV over 46 to 48 hours Q2W). | - Favezelimab
- Pembrolizumab
- Irinotecan
- Leucovorin (Calcium Folinate)
- Fluorouracil [5-FU]
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Part B: Favezelimab/Pembrolizumab | Experimental | Participants receive favezelimab/pembrolizumab (favezelimab and pembrolizumab administered as a co-formulation) IV infusion on Day 1 of each 21-day cycle. | - Favezelimab/Pembrolizumab
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Part B: Favezelimab Dose G+Pembro+Lenvatinib | Experimental | Participants receive favezelimab Dose G IV infusion on Day 1 of each 21 day cycle PLUS pembrolizumab IV infusion administered sequentially on Day 1 of each 21-day cycle PLUS oral lenvatinib (20 mg) each day of 21-day cycle. | - Favezelimab
- Pembrolizumab
- Lenvatinib
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