Inclusion Criteria:

          -  Eligible for study when participant is 1 year to 21 years at the time of diagnosis

          -  Eligible Ages in Australia and Canada; 2 years to 21 years

          -  De novo high-risk (HR) Ph-like B-ALL for which any of following criteria are present
             at diagnosis:

               -  Age ≥ 10 years

               -  White blood cell (WBC) ≥ 50 × 10^3/μL

               -  CNS3 leukemia at diagnosis

               -  Systemic steroid pretreatment without presteroid WBC documentation

          -  Diagnostic bone marrow or peripheral blood sample must have gene expression profiling
             and downstream genetic testing performed by submitting diagnostic specimens under the
             COG AALL08B1 or APEC14B1 biology studies, or AALL1131 or its successor study.
             Specimens must demonstrate a Ph-like expression profile (ie, LDA-positive) as tested
             by low density microarray testing at the COG ALL reference laboratory or TriCore
             laboratory at the University of New Mexico AND must contain 1 of the following genetic
             lesions: (determined at COG ALL reference laboratories, or equivalent
             CAP/CLIA-certified laboratories approved by the medical monitor:

               1. CRLF2 rearrangement* with confirmed JAK1 or JAK2 mutation (JAK+)

               2. CRLF2 rearrangement* without JAK mutation

               3. Other JAK pathway alterations (eg, JAK2 fusions, EPOR fusions, SH2B3 deletions,
                  IL7RA mutations) with or without CRLF2-R, or CRLF2-R with unknown JAK status*† as
                  determined by a COG ALL Reference Laboratory

          -  Completed a 4-drug Induction therapy regimen (modified aBFM regimen or equivalent) in
             Study AALL1131 or its successor study, or as per the institutional standard of care
             for HR B-ALL and have had end-Induction minimal residual disease (MRD) assessed

          -  Male and female subjects of reproductive non childbearing potential or willing to take
             appropriate precautions to avoid pregnancy or fathering a child for the duration of
             study participation

        Exclusion Criteria:

          -  Receipt of any other cytotoxic chemotherapy before Induction therapy, with exception
             of hydroxyurea or steroid pretreatment

          -  Trisomy 21 (Down syndrome)

          -  BCR-ABL1-rearranged (Ph+) ALL

          -  Calculated creatinine clearance or radioisotope glomerular filtration rate < 70
             mL/min/1.73 m^2

          -  Alanine aminotransferase ≥ 5 × upper limit of normal (ULN) for age

          -  Direct bilirubin ≥ 1.5 × ULN (may be assumed if total bilirubin is below ULN)

          -  History or evidence of cirrhosis

          -  Platelet count < 75 × 10^3/μL

          -  Absolute neutrophil count (ANC) < 750/μL

          -  Positive screen for hepatitis B or C

          -  Known human immunodeficiency virus infection