PRIMARY OBJECTIVES:
I. To explore basal levels and effects of durvalumab in combination with chemotherapy on
molecular markers in immune-related pathways, including but not limited to, deoxyribonucleic
acid (DNA) copy number, mutation, and level of ribonucleic acid (RNA) and protein expression,
before and after durvalumab and chemotherapy treatment in women with primary advanced high
grade serous ovarian, fallopian tube, or primary peritoneal cancer.
SECONDARY OBJECTIVES:
I. To evaluate progression-free survival of paclitaxel and carboplatin and durvalumab in
patients with advanced stage, metastatic ovarian cancer undergoing neoadjuvant chemotherapy.
II. To describe the feasibility of combination therapy and maintenance durvalumab in this
population.
III. To evaluate the safety, tolerability and pharmacokinetics (PK) of combination and
maintenance durvalumab.
IV. To report overall survival.
EXPLORATORY OBJECTIVES:
I. To evaluate circulating lymphoid populations (subsets). II. To determine tissue programmed
death-ligand 1 (PD-L1) expression and T-cell infiltration.
III. To measure circulating immune-related cytokines/chemokines. IV. To capture patient
reported outcomes (symptoms, quality of life, and patient utilities).
OUTLINE:
NEOADJUVANT CHEMOTHERAPY: Before debulking surgery, patients receive durvalumab and
carboplatin intravenously (IV) over 1 hour on day 1, and paclitaxel IV over 3 hours on days
1, 8, and 15. Treatment repeats every 21 days for up to 3 courses in the absence of disease
progression or unacceptable toxicity. Patients then undergo debulking surgery.
SURGERY: After 3 courses of chemotherapy, patients undergo debulking laparoscopic surgery.
ADJUVANT THERAPY: Beginning after debulking surgery, patients receive carboplatin IV over 1
hour on day 1, paclitaxel IV over 3 hours on days 1, 8, and 15, and durvalumab IV over 1 hour
on day 1. Treatment repeats every 21 days for up to 3 courses in the absence of disease
progression or unacceptable toxicity.
MAINTENANCE THERAPY: Patients receive durvalumab IV over 1 hour on day 1 and 15. Treatment
repeats every 28 days for up to 7 courses in the absence of disease progression or
unacceptable toxicity.
After completion of study treatment, patients are followed up at 30 days, 2, 3, 4, 6, 8, 9,
10, and 12 months, and then every 6 months thereafter.
Inclusion Criteria:
- Written informed consent and any locally-required authorization (e.g., Health
Information Portability and Accountability Act [HIPAA] in the United States of America
[USA], European Union [EU] Data Privacy Directive in the EU) obtained from the subject
prior to performing any protocol-related procedures, including screening evaluations
- Histology showing high-grade epithelial non-mucinous ovarian, primary peritoneal, or
fallopian tube cancer
- No prior treatment for primary advanced (stage III or IV) epithelial ovarian, primary
peritoneal, or fallopian tube carcinoma such as irradiation, chemotherapy, hormonal
therapy, immunotherapy, investigational therapy, surgery, and/or other concurrent
agents or therapies
- A disposition to neoadjuvant chemotherapy with planned interval tumor reductive
surgery after 3 complete cycles of treatment
- Planned chemotherapy with combination carboplatin and paclitaxel given intravenously
- Have measurable disease based on Response Evaluation Criteria in Solid Tumors (RECIST)
version 1.1
- Measurable disease is defined at least one lesion that can be accurately measured
in at least one dimension (longest dimension to be recorded); each target lesion
must be > 20 mm when measured by conventional techniques, including palpation,
plain x-ray, computed tomography (CT), and magnetic resonance imaging (MRI), or >
10 mm when measured by spiral CT
- Patients with non-measurable but evaluable solid tumors may be deemed eligible
contingent upon principal investigator (PI) review; a non-measurable but
evaluable solid tumor is defined as either unidimensionally measurable lesions,
masses with margins not clearly defined, or lesions with maximal perpendicular
diameters < 10 mm that can still be evaluated for the primary endpoint
- Peripheral neuropathy grade 0 or 1 by National Cancer Institute (NCI) Common
Terminology Criteria for Adverse Events (CTCAE) version 4.03
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Life expectancy >= 12 weeks
- Hemoglobin (Hgb) >= 9 g/dL
- Absolute neutrophil count (ANC) >= 1.5 x 10^9/L (> 1500 per mm^3)
- Platelet count >= 100 x 10^9/L (> 100,000 per mm^3)
- Serum bilirubin =< 1.5 x institutional upper limit of normal (ULN)
- Aspartate Transaminase (AST) and alanine transaminase (ALT) =< 2.5 x institutional
upper limit of normal (ULN) unless liver metastases are present, in which case it must
be =< 5 x ULN
- Serum creatinine clearance (CL) > 40 mL/min by the Cockcroft-Gault formula or by
24-hour urine collection for determination of creatinine
- Subjects must either be of non-reproductive potential (i.e., post-menopausal by
history: >= 60 years old and no menses for >= 1 year without an alternative medical
cause; OR history of hysterectomy, OR history of bilateral tubal ligation, OR history
of bilateral oophorectomy) or must have a negative serum pregnancy test upon study
entry
- Subject is willing and able to comply with the protocol for the duration of the study
including undergoing treatment and scheduled visits and examinations including follow
up
- Pre-treatment tumor tissue available for research purposes; this tissue can be
collected from preoperative laparoscopy, other diagnostic biopsy, or a
research-specific biopsy; this pre-treatment tumor must be amenable to repeat tissue
sampling after induction therapy
- Signed informed consent on protocol LAB02-188
- For participation in the patient-reported outcomes and qualitative interviews,
subjects must be fluent in English
Exclusion Criteria:
- Involvement in the planning and/or conduct of the study (applies to both AstraZeneca
staff and/or staff at the study site)
- Previous enrollment in the present study
- Prior treatment for ovarian, fallopian tube, or primary peritoneal cancer
- Histology showing mucinous or low grade epithelial carcinoma
- Participation in another clinical study with an investigational product during the
last 4 weeks
- Any previous treatment with a programmed cell death protein 1 (PD1) or programmed cell
death ligand 1 (PD-L1) inhibitor, including durvalumab
- History of another primary malignancy except for: malignancy treated with curative
intent and with no known active disease >= 5 years before the first dose of study drug
and of low potential risk for recurrence; adequately treated non-melanoma skin cancer
or lentigo maligna without evidence of disease; or adequately treated carcinoma in
situ without evidence of disease e.g., cervical cancer in situ
- Mean QT interval corrected for heart rate (QTc) >= 470 ms calculated from 3
electrocardiograms (ECGs) using Bazett's correction
- Current or prior use of immunosuppressive medication within 28 days before the first
dose of durvalumab, with the exceptions of intranasal and inhaled corticosteroids or
systemic corticosteroids at physiological doses, which are not to exceed 10 mg/day of
prednisone, or an equivalent corticosteroid
- Any unresolved toxicity (> CTCAE grade 2) from previous anti-cancer therapy; any prior
grade >= 3 immune-related adverse event (irAE) while receiving any previous
immunotherapy agent, or any unresolved irAE > grade 1
- Active or prior documented autoimmune disease within the past 2 years; NOTE: Subjects
with vitiligo, Grave's disease, or psoriasis not requiring systemic treatment (within
the past 2 years) are not excluded
- Active or prior documented inflammatory bowel disease (e.g., Crohn's disease,
ulcerative colitis)
- History of primary immunodeficiency
- History of allogeneic organ transplant
- History of hypersensitivity to durvalumab or any excipient
- History of hypersensitivity to paclitaxel or carboplatin or their excipients
- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, uncontrolled hypertension, unstable
angina pectoris, cardiac arrhythmia, active peptic ulcer disease or gastritis, active
bleeding diatheses including any subject known to have evidence of acute or chronic
hepatitis B, hepatitis C or human immunodeficiency virus (HIV), or psychiatric
illness/social situations that would limit compliance with study requirements or
compromise the ability of the subject to give written informed consent
- Known history of previous clinical diagnosis of tuberculosis
- History of leptomeningeal carcinomatosis
- Receipt of live attenuated vaccination within 30 days prior to study entry or within
30 days of receiving durvalumab
- Female subjects who are pregnant/breast-feeding or who are of reproductive potential
and not employing acceptable methods of birth control; acceptable methods of
contraception include true abstinence in line with the preferred and usual lifestyle
choice of the patient, tubal ligation, vasectomized partner, barrier methods (e.g.,
cap plus spermicide, sponge plus spermicide, diaphragm plus spermicide, or male condom
plus a spermicide), intrauterine device methods (e.g., Copper T or
Levonorgestrel-releasing intrauterine system), or hormonal methods (e.g., any
registered and marketed contraceptive agent that contains an estrogen and/or a
progestational agent) and that is administered via the oral, subcutaneous,
transdermal, intrauterine, or intramuscular route as an implant, hormone shot or
injection, combined pill, minipill or patch; all methods of contraception should be
used in combination with the use of a condom by their male sexual partner for
intercourse
- Any condition that, in the opinion of the investigator, would interfere with
evaluation of study treatment or interpretation of patient safety or study results
- Symptomatic or uncontrolled brain metastases requiring concurrent treatment, inclusive
of but not limited to surgery, radiation and/or corticosteroids
- Subjects with uncontrolled seizures
