Inclusion Criteria:

          -  Patients must have one of the following hematologic malignancies: acute myelogenous
             leukemia (AML), induction failure, high-risk for relapse first remission (with
             intermediate-risk or high-risk cytogenetics including complex karyotype, abnormal
             [abn][3q], -5/5q-, -7/7q-, abn[12p], abn[17p], myeloid/lymphoid or mixed-lineage
             leukemia [MLL] gene re-arrangement and t [6;9]47, fms related tyrosine kinase 3 [flt3]
             mutation positive and/or evidence of minimal residual disease by flow cytometry),
             secondary leukemia from prior chemotherapy and/or arising from myelodysplastic
             syndromes (MDS), any disease beyond first remission

          -  Myelodysplastic syndrome (MDS): Primary or therapy related, including patients that
             will be considered for transplant; these include any of the following categories: 1)
             revised International Prognostic Scoring System (IPSS) intermediate and high risk
             groups, 2) malondialdehyde (MDA) with transfusion dependency, 3) failure to respond or
             progression of disease on hypomethylating agents, 4) refractory anemia with excess of
             blasts, 5) transformation to acute leukemia, 6) chronic myelomonocytic leukemia, 7)
             atypical MDS/myeloproliferative syndromes, 8) complex karyotype, abn(3g), -5/5g-,
             -7/7g-, abn(12p), abn(17p)

          -  Acute lymphoblastic leukemia (ALL): Induction failure, primary refractory to treatment
             (do not achieve complete remission after first course of therapy) or are beyond first
             remission including second or greater remission or active disease; patients in first
             remission are eligible if they are considered high risk, defined as any of the
             following detected at any time: with translocations 9;22 or 4;11, hypodiploidy,
             complex karyotype, secondary leukemia developing after cytotoxic drug exposure, and/or
             evidence of minimal residual disease or acute biphenotypic leukemia, or double hit
             non-Hodgkin's lymphoma

          -  Non-Hodgkin's lymphoma (NHL) in second or third complete remission, or relapse
             (including relapse post autologous hematopoietic stem cell transplant); relapsed
             double hit lymphomas; patients with options for treatment that are known to be
             curative are not eligible

          -  Small lymphocytic lymphoma (SLL), or chronic lymphocytic leukemia (CLL) with
             progressive disease following a minimum of two lines of standard therapy

          -  Chronic myeloid leukemia (CML) second chronic phase or accelerated phase

          -  Hodgkin's disease (HD): Induction failures, after first complete remission, or relapse
             (including relapse post autologous hematopoietic stem cell transplant), or those with
             active disease

          -  Multiple myeloma: stage II or III, symptomatic, secretory multiple myeloma requiring
             treatment

          -  A person (such as a haploidentical family member) or unit of cord blood must be
             identified as a source of back-up cells source in case of engraftment failure

          -  Patient age criteria: age >= 15 and =< 45 years (myeloablative regimen 1; age >= 15
             and =< 80 years (nonmyeloablative regimen 2) at the discretion of the investigator(s);
             age >= 15 and =< 80 years old that in the opinion of the investigator(s) would
             preclude myeloablative therapy may receive reduced intensity regimen 3

          -  Performance score of at least 60% by Karnofsky

          -  Left ventricular ejection fraction of at least 40% (myeloablative regimen 1, reduced
             intensity regimen 3)

          -  Left ventricular ejection fraction of at least 30% (nonmyeloablative regimen 2)

          -  Pulmonary function test (PFT) demonstrating an adjusted diffusion capacity of least
             50% predicted value for hemoglobin concentration (myeloablative regimen 1, reduced
             intensity regimen 3)

          -  Serum creatinine within normal range, or if serum creatinine outside normal range,
             then renal function (measured or estimated creatinine clearance or glomerular
             filtration rate [GFR]) > 40mL/min/1.73 m^2

          -  Serum glutamate pyruvate transaminase (SGPT)/bilirubin < to 2.0 x normal
             (myeloablative regimen 1), reduced intensity regimen 3; SGPT/bilirubin < to 4.0 x
             normal (nonmyeloablative regimen 2)

          -  Negative beta human chorionic gonadotropin (HCG) test in a woman with child bearing
             potential defined as not post-menopausal for 12 months

          -  Patients with options for treatment that are known to be curative are not eligible

          -  Patients enrolled in this study may be enrolled on other supportive care
             investigational new drug (IND) studies at the discretion of the principal investigator
             (PI)

        Exclusion Criteria:

          -  Human immunodeficiency virus (HIV) positive; HIV results will be determined by nucleic
             acid testing

          -  Uncontrolled serious medical condition such as persistent septicemia despite adequate
             antibiotic therapy, decompensated congestive heart failure despite cardiac medications
             or pulmonary insufficiency requiring intubation (excluding primary disease for which
             cord blood [CB] transplantation is proposed), or psychiatric condition that would
             limit informed consent

          -  Active central nervous system (CNS) disease in patient with history of CNS malignancy

          -  Availability of appropriate, willing, human leukocyte antigen (HLA)-matched related
             stem cell donor