This study will evaluate the safety, efficacy, pharmacokinetics, and immunogenicity of
obinutuzumab + Atezo + Pola in participants with relapsed or refractory (RR) FL and rituximab
+ Atezo + Pola in participants with RR DLBCL. The study will include an initial
dose-escalation phase designed to determine the recommended Phase 2 dose (RP2D) for Pola in
this treatment combination, followed by an expansion phase in which Pola will be given at the
RP2D. All participants will receive induction treatment with obinutuzumab + Atezo + Pola for
6 cycles. RR FL participants achieving a complete response (CR), partial response (PR), or
stable disease (SD) at the end of induction (EOI) will receive maintenance treatment with
obinutuzumab.
Inclusion Criteria:
- Eastern Cooperative Oncology Group (ECOG) Performance Status of 0, 1, or 2
- For obinutuzumab + Atezo + Pola treatment group: relapsed or refractory FL after
treatment with at least one prior chemoimmunotherapy regimen that included an
anti-Cluster of Differentiation (CD)20 monoclonal antibody and for which no other more
appropriate treatment option exists as determined by the investigator
- For rituximab + Atezo + Pola treatment group: relapsed or refractory DLBCL after
treatment with at least one prior chemoimmunotherapy regimen that included an
anti-CD20 monoclonal antibody, in participants who are not eligible for second line
combination (immuno-) chemotherapy and autologous stem-cell transplantation or who
have failed second line combination (immuno-) chemotherapy or experienced disease
progression following autologous stem-cell transplantation
- Histologically documented CD20-positive lymphoma and fluorodeoxyglucose (FDG)-avid
lymphoma (that is PET-positive lymphoma) with at least one bi-dimensionally measurable
lesion
- Availability of a representative tumor specimen and the corresponding pathology report
for retrospective central confirmation of the diagnosis of FL or DLBCL
- For women who are not postmenopausal or surgically sterile: agreement to remain
abstinent or to use contraceptive methods that result in a failure rate of less than
(<) 1% per year during the treatment period for greater than or equal to (>=) 5 months
after last dose of Atezo, >= 12 months after last dose of rituximab, >= 12 months
after last dose of Pola, and >= 18 months after last dose of obinutuzumab
- For men: agreement to remain abstinent or to use contraceptive measures that result in
a failure rate of <1% per year during the treatment period and for at least 3 months
after last dose of obinutuzumab, rituximab, and Atezo and for 5 months after last dose
of Pola, and agreement to refrain from donating sperm during this same period
Exclusion Criteria:
- Grade 3b follicular lymphoma
- History of transformation of indolent disease to DLBCL
- Known CD20-negative status at relapse or progression; CNS lymphoma or leptomeningeal
infiltration
- Prior allogeneic stem cell transplantation (SCT), completion of autologous SCT within
100 days prior to Day 1 of Cycle 1 (D1C1)
- Prior anti-cancer therapy including: Fludarabine or alemtuzumab within 12 months prior
to D1C1; radioimmunoconjugate within 12 weeks prior to D1C1; monoclonal antibody or
antibody drug conjugate (ADC) within 5 half-lives or 4 weeks prior to D1C1 ;
radiotherapy, chemotherapy, hormonal therapy, or targeted small-molecule therapy
within 2 weeks prior to D1C1; anti-programmed death-1 (anti-PD-1), anti-programmed
death-ligand 1 (anti-PD-L1), anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA4),
anti-CD137/41-BB agonist, or anti-CD40 agonist antibodies
- Treatment with systemic immunosuppressive medications, including but not limited to
prednisone, azathioprine, methotrexate, thalidomide, and anti-tumor necrosis factor
agents within 2 weeks prior to D1C1
- History of solid organ transplantation and of severe allergic or anaphylactic reaction
to humanized, chimeric, or murine monoclonal antibodies
- Active infection; positive for hepatitis B surface agent (HbsAg), total hepatitis B
core antibody (HBcAb), or hepatitis C virus (HCV) antibody at screening; known history
of HIV positive status, progressive multifocal leukoencephalopathy (PML), autoimmune
disease
- Vaccination with a live virus vaccine or live attenuated vaccine within 28 days prior
to D1C1
- Pre-existing Grade greater than (>) 1 neuropathy
- Major surgical procedure other than for diagnosis within 28 days prior to D1C1
- Inadequate hematologic function, renal function, and liver function
- Pregnant or lactating women
- Life expectancy < 3 months