Inclusion Criteria:

          -  Obtain of informed consent.

          -  Histologically or cytologically confirmed non-small cell lung cancer.

          -  World Health Organization (WHO) performance status (PS) of 0 to 2.

          -  Measurable lesions as defined by RECIST criteria.

          -  Second-line or more treatments.

          -  Wild type of epidermal-growth-factor receptor (EGFR).

          -  Life expectancy ≥12 weeks.

          -  Organ functions normal, as defined below, within two weeks of randomization:

             • Hb≥90g/L Absolute neutrophils count(ANC)≥1.5×109/L Platelets≥80×109/L Serum
             bilirubin≤2×ULN; Aspartate transaminase(AST) and alanine transaminase
             (ALT)≤2.5×ULN(≤5×ULN if liver metastases) Creatinine clearance≥45ml/min or
             Cr≤1.25×ULN.

          -  Females of child-bearing potential must have negative serum pregnancy test.

          -  Sexually active males and females (of childbearing potential) willing to practice
             contraception during the study.

        Exclusion Criteria:

          -  Small cell lung cancer.

          -  Newly diagnosed Central Nervous System (CNS) metastases that have not yet been
             definitively treated with surgery and/or radiation.

          -  Uncontrolled hypertension.

          -  Myocardial ischemia or infarction more than stage II, cardiac insufficiency.

          -  Abnormal coagulation (INR>1.5 or PT>ULN+4, or APTT>1.5 ULN), bleeding tendency or
             receiving coagulation therapy.

          -  Difficulties in taking pills (inability to swallow tablets,GI tract resection, chronic
             bacillary diarrhea and intestinal obstruction).

          -  Hemoptysis, more than 2.5ml daily.

          -  Thrombosis in 12 months, including pulmonary thrombosis, stoke, or deep venous
             thrombosis.

          -  Unhealed bone fracture or wound for long time.

          -  Received big surgery, had bone fracture or ulcer in 4 weeks.

          -  Urine protein≥++, or urine protein in 24 hours≥1.0g.

          -  Pregnant or lactating woman.