Inclusion Criteria:

          1. Patients with histologic diagnosis for one of the following histologies according to
             the World Health Organization: documented at initial diagnosis or at relapse:

               -  Diffuse large cell lymphoma, B-cell (includes primary mediastinal B-cell
                  lymphoma, T-cell rich B-cell lymphoma);

               -  Previous indolent lymphoma (follicular lymphoma, marginal zone lymphoma,
                  including extranodal MALT lymphoma, lymphoplasmacytoid lymphoma) with
                  transformation to diffuse large B-cell lymphoma at relapse (biopsy proof of
                  transformation is mandatory);

               -  Follicular lymphoma grade 3B;

               -  Biopsy proof of disease at initial diagnosis is mandatory. A biopsy at relapse is
                  mandatory. A histological diagnosis (core or excisional biopsy) is strongly
                  encouraged; a cytological diagnosis is acceptable only in the event that tissue
                  cannot be obtained.

             Patients must be CD20+ in order to be eligible for the study.

          2. Clinically and/or radiologically measurable disease (1 site bidimensionally
             measurable). Measurements/ evaluations must be done within 28 days prior to
             registration.

             Baseline FDG-PET scan, if available, must be positive (known FDG-avid lymphoma)

          3. Patient must have had at least one previous regimen of therapy for their disease.
             Patients must have relapsed or progressed after R-CHOP chemotherapy or equivalent.

          4. Patient age is ≥16 years. Patients older than 70 years of age are not recommended for
             this study. (Note that the lower age limit at each centre will be determined by that
             centre's policy regarding the age at which an individual may sign his or her own
             consent.)

          5. ECOG performance status of 0, 1, 2 or 3.

          6. Patient must be considered fit for intensive chemotherapy and ASCT and an appropriate
             candidate to receive salvage chemotherapy and ASCT.

          7. Laboratory Requirements: (must be done within 14 days of registration)

             Hematology:

               -  Granulocytes (AGC) > 1.0 x 109/L (independent of growth factor support)

               -  Platelets > 100 x 109/L (50 x 109/L if bone marrow involvement by lymphoma,
                  independent of transfusion support)

             Biochemistry:

               -  AST and ALT < 3x ULN

               -  Serum total bilirubin < 1.5x ULN (≤ 5x ULN if Gilberts Disease)

               -  Serum Creatinine < 1.5x ULN (or estimated GFR of ≥40 mL/min/1.73m2 using
                  Cockcroft Gault formula)

               -  International normalized ratio (INR) > 1.5 × the ULN in the absence of
                  therapeutic anticoagulation

               -  Partial thromboplastin time (PTT) or activated partial thromboplastin time (aPTT)

               -  > 1.5 × the ULN in the absence of a lupus anticoagulant

          8. A Women of childbearing potential (WOCBP) is defined as any female who has experienced
             menarche and who has not undergone surgical sterilization (hysterectomy or bilateral
             oophorectomy) and is not postmenopausal. Menopause is defined as 12 months of
             amenorrhea in a woman over age 45 years in the absence of other biological or
             physiological causes. Women of child bearing potential (who are heterosexually active)
             and men (who are sexually active with WOCBP), must be practicing a highly effective
             method of birth control (Pearl Index <1) such as oral contraceptives, intrauterine
             device, sexual abstinence or barrier method of contraception in conjunction with
             spermicidal jelly during study treatment and in female patients for 18 months after
             end of antibody treatment Men must agree to not donate sperm during and after the
             study. These restrictions apply for 18 months after the last dose of study drug.

             Women of childbearing potential must have a pregnancy test taken (either by serum
             beta-human chorionic gonadotropin [β-hCG]) or urine) and proven negative within 14
             days prior to registration.

             Women who are pregnant or breastfeeding are ineligible for this study.

          9. Patient consent must be appropriately obtained in accordance with applicable local and
             regulatory requirements. Each patient must sign a consent form prior to enrollment in
             the trial to document their willingness to participate.

         10. Patients must be accessible for treatment and follow-up. Patients randomized on this
             trial must be treated and followed at the participating centre. Investigators must
             assure themselves the patients randomized on this trial will be available for complete
             documentation of the treatment, response assessment, adverse events, and follow-up.

         11. Protocol treatment is to begin within 5 working days of patient registration

        Exclusion Criteria:

          1. Patients who have been previously treated with obinutuzumab.

          2. Life expectancy < 90 days

          3. Patients with a history of other malignancies, except: adequately treated non-melanoma
             skin cancer and superficial bladder cancer, curatively treated in-situ cancer of the
             cervix or breast, or localized excised prostate cancer, other solid tumors curatively
             treated with no evidence of disease for > 5 years.

          4. Active and uncontrolled central nervous system involvement, meningeal or parenchymal.
             Patients with CNS disease at initial presentation and who are in a CNS CR at the time
             of relapse are eligible. MRI scanning and / or lumbar puncture should be performed if
             there is clinical suspicion of active CNS disease.

          5. Patients with symptoms suggestive of Progressive Multifocal Leukoencephalopathy (PML).

          6. Major surgery performed within 4 weeks prior to registration.

          7. Known history of human immunodeficiency virus (HIV), active Hepatitis C Virus
             infection, active Hepatitis B Virus infection or any uncontrolled active systemic
             infection requiring intravenous (IV) antibiotics. Patients with positive hepatitis B
             serology are defined as positive Hepatitis B surface antigen (HBsAg) or core antibody
             (anti-HBc). These patients should consult liver disease experts before start of
             treatment and should be monitored and managed following local medical standards to
             prevent hepatitis reactivation. Patients with Hepatitis B serology suggestive of
             infection are eligible if they are HBV DNA negative and concurrently treated with
             anti-viral therapy. Patients with a past history of hepatitis C who have eradicated
             the virus (defined as negative PCR for HCV RNA) are eligible.

          8. Patients who have been vaccinated with live, attenuated vaccines within 4 weeks prior
             to registration.

          9. Known history of stroke or intracranial hemorrhage within 6 months prior to
             registration.

         10. Clinically significant cardiovascular disease such as uncontrolled or symptomatic
             arrhythmias, congestive heart failure, or myocardial infarction within 6 months of
             Screening, or any Class 3 (moderate) or Class 4 (severe) cardiac disease as defined by
             the New York Heart Association Functional Classification.

         11. Any serious active disease or co-morbid medical condition, including psychiatric
             illness, judged by the local investigator to preclude safe administration of the
             planned protocol treatment or required follow-up.

         12. Any other serious intercurrent illness, life threatening condition, organ system
             dysfunction, or medical condition judged by the local investigator to compromise the
             subject's safety, preclude safe administration of the planned protocol treatment or
             required follow-up, including (for example):

               -  Active, uncontrolled bacterial, fungal, or viral infection, history of chronic or
                  recurrent infection

               -  Clinically significant cardiac dysfunction or cardiovascular disease.

         13. Patients are not eligible if they have a known hypersensitivity to the study drugs or
             their component, or a history of severe allergic or anaphylactic reactions to
             humanized or murine monoclonal antibodies, or a known sensitivity or allergy to murine
             products