Clinical Trials /

CIK-Cells in Relapsing Patients With Acute Leukemia or Myelodysplastic Syndromes After SCT.

NCT02752243

Description:

Multi-site, non-randomized Phase I/II study involving children and adults.

Related Conditions:
  • Acute Lymphoblastic Leukemia
  • Acute Myeloid Leukemia
  • Myelodysplastic Syndromes
Recruiting Status:

Recruiting

Phase:

Phase 1/Phase 2

Trial Eligibility

Document

Title

  • Brief Title: CIK-Cells in Relapsing Patients With Acute Leukemia or Myelodysplastic Syndromes After SCT.
  • Official Title: A Prospective Phase I/II Study to Investigate the Feasibility, Safety and Efficacy of IL-15 Activated Cytokine Induced Killer (CIK) Cells in Relapsing Patients With Acute Leukemia or Myelodysplastic Syndromes After Allogeneic SCT

Clinical Trial IDs

  • ORG STUDY ID: FFM-CIK-Cell Study 01
  • SECONDARY ID: 2013-005446-11
  • NCT ID: NCT02752243

Conditions

  • Myelodysplastic Syndromes
  • Acute Leukemia

Interventions

DrugSynonymsArms
CIK-CellsCIK-Cells

Purpose

Multi-site, non-randomized Phase I/II study involving children and adults.

Detailed Description

      This is a phase I/II multicenter-study to investigate the feasibility safety and efficacy of
      interleukin (IL)-15 activated CIK cells in patients with acute leukemia or myelodysplastic
      syndrome (MDS) showing evidence of relapse after allogeneic stem cell transplantation (SCT).

      CIK cell infusions will be given with an interval of 4-6 weeks according to a dose escalation
      schedule in patients with impending relapse after allogeneic SCT. In presence of acute graft
      versus host disease (aGvHD) ≥ grade II, the next scheduled infusion will not be administered.
    

Trial Arms

NameTypeDescriptionInterventions
CIK-CellsExperimentalIL-15 activated CIK cells individually generated from PB mononuclear cells of the original stem cell donors.
  • CIK-Cells

Eligibility Criteria

        Inclusion Criteria:

        Acute leukemia and MDS patients with molecular or cytogenetic relapse in peripheral blood
        (PB) or bone marrow (BM) samples obtained during monitoring for relapse after allogeneic
        SCT.

        MRD detected by Ig/TCR gene rearrangement testing or any detected disease specific DNA or
        RNA sequence or disease specific cell surface Proteins or mixed recipient chimerism (MC) ≥
        1% and < 40%, or levels ≥ 10-4 of BCR-ABL/ABL ratio or any other disease specific
        cytogenetic abnormality will trigger CIK cell interventions.

          -  Respecting MC, MC = 1% of autologous/recipient signals in PB samples must be confirmed
             by another PB or BM sample within one week. Patients with MC = 1% of
             autologous/recipient signals in CD33+ and/or CD34+ subpopulations in PB samples must
             be confirmed by BM analyses within one week. Acute leukemia and MDS patients with MC =
             1% of autologous/recipient signals including signals in CD33+ and/or CD34+
             subpopulations in BM samples must not be confirmed.

          -  Acute leukemia and MDS patients with frank relapse ≥ 120 days after allogeneic SCT who
             achieved complete remission (CR) or blast clearance (i.e. <5% blasts) in the bone
             marrow after re-induction chemotherapy.

          -  All patients must be in complete remission or have achieved blast clearance (i.e. <5%
             blasts) in the bone marrow before 1st CIK cell treatment (bone marrow assessment at a
             maximum of 7 days in advance of 1st treatment is obligatory).

          -  Patients without immunosuppressive agents and steroids for at least 7 days.

          -  Patients without chemo- or immune therapy during CIK cell treatment, except patients
             with thyrosine-kinase inhibitors (TKI) for treatment of BCR-ABL positive leukemia.
             Last DLI treatment must be 4 weeks before 1st CIK cell treatment.

          -  Patients with < grade II aGvHD.

          -  Patients with Karnowsky or Lansky performance status ≥ 50%.

          -  Patients and/or his/her legal representative having reviewed the patient
             information/informed consent form and have had their questions answered and have given
             written informed consent.

        Exclusion Criteria:

          -  Acute leukemia and MDS patients with hematologic relapse < day 120 after allogeneic
             stem cell transplantation.

          -  Patients with 5% and more malignant cells in a representative bone marrow analysis
             performed at a maximum of 7 days before 1st CIK cell treatment (obligatory).

          -  Patients with immunosuppressive agents or steroids.

          -  Patients with chemo- or immune therapy, except patients with thyrosine-kinase
             inhibitors (TKI) for BCR-ABL positive leukemias.

          -  Patients with ≥ grade II GvHD.

          -  Patients with rapid T cell regeneration and any signs of GvHD

          -  Patients with Karnowsky or Lansky performance status < 50%.

          -  Patients and/or his/her legal representative having reviewed the patient
             information/informed consent form and have had their questions answered and have not
             given written informed consent.

          -  HIV-positive patients.

          -  HBV/HCV positive patients.

          -  Patients with prior solid organ transplantation.

          -  Patients treated with any other investigational product within the last 28 days or
             five half-lives (whichever is longer).

          -  Hypersensitivity to any component of the study drug

          -  Female patients of child-bearing potential not agreeing to use a highly effective
             method of birth control resulting in a low failure rate (i.e. < 1%) when used
             consistently and correctly.

          -  Male patients with female partners of childbearing potential not agreeing to use a
             highly effective method birth control resulting in a low failure rate (i.e. < 1%) when
             used consistently and correctly.

          -  Pregnancy/Breastfeeding.

          -  Patients with severe infections or signs/symptoms of infection within 2 weeks prior to
             study start.
      
Maximum Eligible Age:80 Years
Minimum Eligible Age:N/A
Eligible Gender:All
Healthy Volunteers:No

Primary Outcome Measures

Measure:The occurrence of grade three or four acute Graft versus Host Disease (aGvHD)
Time Frame:two until four weeks after CIK-Cell Infusion
Safety Issue:
Description:

Secondary Outcome Measures

Measure:Efficacy of CIK-Cells analyzed by progression free survival
Time Frame:one year
Safety Issue:
Description:
Measure:Overall survival
Time Frame:one year
Safety Issue:
Description:

Details

Phase:Phase 1/Phase 2
Primary Purpose:Interventional
Overall Status:Recruiting
Lead Sponsor:Peter Bader

Trial Keywords

  • acute leukemia
  • myelodysplastic syndrome (MDS)
  • Stem Cell Transplantation

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