Inclusion Criteria:

          1. Age ≥18 years of age .

          2. Histologically or cytologically confirmed metastatic pancreatic ductal adenocarcinoma.

          3. Capable of providing informed consent and complying with Trial procedures.

          4. Karnofsky Performance Status (KPS) of ≥ 70%.

          5. Life expectancy ≥ 12 weeks.

          6. Measurable tumor lesions according to RECIST 1.1 criteria.

          7. Women must not be able to become pregnant (e.g. post-menopausal for at least 1 year,
             surgically sterile, or practicing adequate birth control methods) for the duration of
             the study. Women of child bearing potential must have a negative serum or urine
             pregnancy test at the Screening Visit and be non-lactating. Both male and female
             patients of reproductive potential must agree to use a reliable method of birth
             control during the study.

        Exclusion Criteria:

          1. Patients must have received no previous radiotherapy, surgery, chemotherapy or
             investigational therapy for the treatment of metastatic disease. Prior treatments in
             the adjuvant setting with gemcitabine and/or 5-FU or gemcitabine administered as a
             radiation sensitizer are allowed, provided at least 6 months have elapsed since
             completion of the last dose and no lingering toxicities are present.

          2. Palliative surgery and/or radiation treatment less than 4 weeks prior to initiation of
             study treatment.

          3. Exposure to any investigational agent within 4 weeks prior to initiation of study
             treatment.

          4. Evidence of central nervous system (CNS) metastasis (negative imaging study, if
             clinically indicated, within 4 weeks of Screening Visit).

          5. History of other malignancies (except cured basal cell carcinoma, superficial bladder
             cancer or carcinoma in situ of the cervix) unless documented free of cancer for ≥5
             years.

          6. Laboratory values: Screening serum creatinine > upper limit of normal (ULN); total
             bilirubin > (ULN); alanine aminotransferase (ALT) and AST ≥ 2.5 ULN or ≥ 5.0×ULN if
             liver metastases are present; absolute neutrophil count <1,500/mm3, platelet
             concentration <100,000/mm3, hematocrit level <27% for females or <30% for males, or
             coagulation tests (prothrombin time [PT], partial thromboplastin time [PTT],
             International Normalized Ratio [INR]) >1.5×ULN unless on therapeutic doses of
             warfarin.

          7. Current, serious, clinically significant cardiac arrhythmias as determined by the
             investigator.

          8. History of HIV infection or active or chronic hepatitis B or C.

          9. Active, clinically significant serious infection requiring treatment with antibiotics,
             anti-virals or anti-fungals.

         10. Major surgery within 4 weeks prior to initiation of study treatment.

         11. Any condition that might interfere with the patient's participation in the study or in
             the evaluation of the study results.

         12. Any condition that is unstable and could jeopardize the patient's participation in the
             study.

         13. Patient has a transplanted organ.

         14. Patients with a history of autoimmune disease.

         15. Prior PD-1 or PD-L1 therapy.

         16. Patients taking any chemo or immunosuppressive steroids (equivalent to > 20 mg
             hydrocortisone per day).

         17. Patients cannot have > Grade 1 pre-existing peripheral neuropathy (per CTCAE).