Inclusion Criteria:

          1. Female participants aged 18 years or older who are postmenopausal.

          2. Histologically proven diagnosis of breast cancer with evidence of metastatic disease
             or locoregional recurrence.

          3. Histological confirmation and documentation of estrogen receptor (ER)-positive status
             (≥1% positive stained cells).

          4. Histological or cytological confirmation and documentation of human epidermal growth
             factor receptor-2 (HER2)-negative status by local laboratory testing using criteria in
             the American Society of Oncology (ASCO)/College of American Pathologists (CAP)
             Clinical Practice Guideline update.

          5. Measurable disease defined as either of the following:

               -  At least 1 extra-osseous lesion that could be accurately measured in at least 1
                  dimension.

               -  The lesion must have measured ≥20 mm with conventional imaging techniques or ≥10
                  mm with spiral CT or MRI. Lymph nodes must be ≥1.5 cm in the short axis to be
                  considered measurable.

               -  Bone lesions (lytic or mixed [lytic plus sclerotic]) in the absence of measurable
                  disease as defined above. Note: Participants with sclerotic/osteoblastic bone
                  lesions only, in the absence of measurable disease, were not eligible.

          6. Progressive Disease (PD) during prior aromatase inhibitor (AI) therapy.

          7. Have a history of brain metastasis provided that all of the following criteria are
             met:

               -  Brain metastases have been treated.

               -  No evidence of PD for ≥3 months before the first dose of study drug.

               -  No hemorrhage after treatment.

               -  Off dexamethasone treatment for ≥4 weeks before the first dose of study drug.

               -  No ongoing requirement for dexamethasone or anti-epileptic drugs.

          8. Eastern cooperative oncology group (ECOG) performance status of 0 or 1.

          9. Clinical laboratory values as specified below within 4 weeks before the first dose of
             study drug:

               -  Bone marrow reserve consistent with absolute neutrophil count (ANC) ≥1.5*10^9/L;
                  platelet count ≥100*10^9/L; hemoglobin (Hgb) ≥9 g/dL.

               -  Total bilirubin ≤1.5*the upper limit of the normal range (ULN), aspartate
                  aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5*ULN (≤5*ULN if
                  liver metastases are present).

               -  Creatinine clearance ≥40 mL/min based on Cockcroft-Gault estimate or based on a
                  12- or 24-hour urine collection.

               -  Fasting serum glucose ≤130 mg/dL and fasting triglycerides ≤300 mg/dL.

        Exclusion Criteria:

          1. Prior therapy with mechanistic target of rapamycin (mTOR), phosphoinositide-3-kinase
             (PI3K), or dual PI3K-mTOR inhibitors, serine/threonine-specific protein kinase (AKT)
             inhibitors, or fulvestrant.

          2. Prior treatment with >1 line of chemotherapy for metastatic breast cancer or for
             locoregional recurrence that was not amenable to resection or radiation therapy with
             curative intent.

          3. Experienced PD on >2 endocrine therapies for metastatic breast cancer or for
             locoregional recurrence that was not amenable to resection or radiation therapy with
             curative intent.

          4. Life-threatening metastatic visceral disease (defined as extensive hepatic involvement
             or symptomatic pulmonary lymphangitic spread).

          5. Poorly controlled diabetes mellitus defined as hemoglobin A1c (glycosylated
             hemoglobin; HbA1c) >7%; participants with a history of transient glucose intolerance
             due to corticosteroid administration may be eligible if all other inclusion/exclusion
             criteria are met.