Inclusion Criteria:

          -  Signed informed consent

          -  Histological or cytological pancreatic adenocarcinoma. Malignant unspecified tumor
             cells in cytological specimen are allowed after investigator assessment, mixed
             histology including adenosquamous carcinoma is allowed

          -  Male or non-pregnant, non-lactating females who are ≥18 years of age at the time of
             signing the informed consent form (ICF)

          -  Non-curable unresectable locally advanced or metastatic pancreatic carcinoma.

          -  A modified Glasgow Prognostic Score (mGPS) criteria of 1 or 2 assessed within 14 days
             of randomization as defined below:

          -  mGPS of 1: CRP > 10 mg/L and albumin ≥ 35 g/L

          -  mGPS of 2: CRP > 10 mg/L and albumin < 35 g/L

          -  No prior antineoplastic chemotherapy or anti-cancer drugs. Patients who have received
             neoadjuvant or adjuvant chemotherapy and who are diagnosed with loco regional
             recurrent or metastatic disease are not eligible

          -  ECOG/WHO Performance Status (PS) 0-1

          -  ≥ 4 weeks since prior major surgery, ≥ 2 weeks since prior minor surgery and ≥ 1 week
             since prior radiation therapy

          -  Measurable disease using the RECIST1.1 criteria, defined as lesions that can be
             measured in at least one dimension and which have not been previously irradiated.
             Longest diameter ≥ 20 mm with conventional techniques or ≥ 10 mm with spiral CT scan
             or MRI

          -  Fertile men and women of childbearing potential (defined as a sexually mature woman
             who (1) has not undergone hysterectomy [the surgical removal of the uterus] or
             bilateral oophorectomy [the surgical removal of both ovaries] or (2) has not been
             naturally postmenopausal for at least 24 consecutive months [ie, has had menses at any
             time during the preceding 24 consecutive months]) must use secure contraception
             methods as follows: intrauterine device, double-barrier contraception, as a condom and
             occlusive cap (diaphragm or cervical/vault caps) with a vaginal spermicidal agent
             (foam/gel/cream/suppository), vasectomized partner who is sterile prior to the female
             subject's entry and is the sole sexual partner for that female, or complete abstinence
             from sexual intercourse from before 2 months entering the study until 6 months after
             end of chemotherapy

          -  Acceptable hematology parameters defined as:

          -  Absolute neutrophil count (ANC) ≥ 1.5 x 10⁹/L

          -  Platelet count ≥ 100 x 10⁹/L

          -  Haemoglobin ≥ 5.6 mmol/L

          -  Acceptable liver function defined as:

          -  Serum bilirubin < 1.5 x upper limit of normal (ULN)

          -  ASAT/ALAT < 2.5 x ULN ( < 5 x ULN with known liver metastasis)

          -  Acceptable renal function with a creatinine clearance ≥ 50 mL/min/ (eg, using the
             Cockroft-Gault formula)

          -  Subjects must have signed and dated a BIOPAC IRB/IEC approved written informed consent
             form in accordance with regulatory and institutional guidelines. This must be obtained
             before the performance of any protocol related procedures that are not part of normal
             subject care

        Exclusion Criteria:

          -  Electrocardiogram (ECG) with significant modifications suggesting a high risk of
             occurrence of angina pectoris or high risk of arrhythmia.

          -  Other malignancies, except adequately treated basal carcinoma or squamous cell
             carcinoma of the skin or in-situ cervix carcinoma or incidental prostate cancer (T1a,
             Gleason score ≤ 6, PSA < 0.5 ng/ml), or any other tumor with a disease free survival
             of ≥ 5 years.

          -  History of serious or concurrent illness or uncontrolled medical disorder; any medical
             condition that might be aggravated by chemotherapy treatment or which could not be
             controlled; including, but not restricted to:

          -  Active infection requiring antibiotics within 2 weeks before the study inclusion

          -  Concurrent congestive heart failure NYHA ( class III - IV )

          -  Unstable angina pectoris, or myocardial infarction within 6 months and/or prior poorly
             controlled hypertension

          -  Inflammatory bowel disease (colitis, Crohns) or other serious gastrointestinal
             conditions associated with risk of perforation

          -  Peripheral neuropathy grade ≥ 2 according to CTCAE v 4.0

          -  Concomitant use of immunosuppressive or myelosuppressive medications that would in the
             opinion of the investigator, increase the risk of serious neutropenic complications.

          -  No known or suspected allergy to the investigational agents or any agents given in
             association with this trial.

          -  Pregnant or lactating women.

          -  Any psychological, familial, sociological, or geographical condition which does not
             permit protocol compliance and medical follow-up.

          -  Enrollment in any other clinical protocol or investigational study with an
             interventional agent or assessments that may interfere with study procedures.