Inclusion Criteria:

          -  Age 18-55 yr.

          -  De novo Ph+ (BCR-ABL)ALL

          -  ECOG score ≤2 unless due to ALL

          -  Absence of significant liver disease, as defined by the following criteria: total
             serum bilirubin ≤1.5 x upper limit of normal (ULN), unless due to Gilbert's syndrome,
             alanine aminotransferase (ALT) ≤2.5 × ULN or ≤5 x ULN if leukemic involvement of the
             liver is present, and aspartate aminotransferase (AST) ≤2.5 × ULN or ≤5 x ULN if
             leukemic involvement of the liver is present.

          -  Adequate pancreatic function as defined by serum lipase and amylase ≤1.5 × ULN.

          -  No history of dyslipidemia, hypertension, thrombotic events or cardiac disease.

          -  For females of childbearing potential, a negative pregnancy test must be documented
             prior to randomization. Female and male patients who are fertile must agree to use an
             effective form of contraception with their sexual partners from randomization through
             4 months after the end of treatment.

          -  informed consent signed, according to national regulation

          -  Patients aged between 56 and 60 years may be selected who could be included in the
             study with the authorization of the Coordinating Investigator with the consolidation
             treatment modified as follows:

        Mercaptopurine (MP): 50 mg / m2, PO on days 1 to 7, 28 to 35 and 56 to 63 MTX: 0.75 g / m2,
        IV (continuous infusion 24 h) on days 1, 28 and 56 ARA-C: 500 mg / m2 / 12 h, IV, days
        14-15 and 42-43 TIT (MTX: 12 mg, ARA-C: 30 mg, hydrocortisone: 20 mg), days 1, 28 and 56
        Ponatinib 30 mg / d PO, from day 1 to 7 days before HSCT

        Exclusion Criteria:

          -  Lymphoid blast crisis of CML,

          -  WHO performance status ≤ 50% (Karnofsky) or ≥ 3 (ECOG).

          -  Active HBV or HCV hepatitis, or AST/ALT ≥ 2.5 x ULN and bilirubin ≥ 1.5 x ULN.

          -  History of acute pancreatitis within 1 year of study or history of chronic
             pancreatitis.

          -  History of alcohol abuse.

          -  Ongoing or active infections.

          -  Uncontrolled hypertriglyceridemia (triglycerides >450 mg/dL).

          -  Clinically significant, uncontrolled or active cardiovascular disease, specifically
             including, but not restricted to: Any history of myocardial infarction, stroke, or
             revascularization, Unstable angina or transient ischemic attack within 6 months prior
             to enrollment Congestive heart failure within 6 months prior to enrollment, or left
             ventricular ejection fraction (LVEF) less than lower limit of normal per local
             institutional standards History of clinically significant (as determined by the
             treating physician) atrial arrhythmia Any history of ventricular arrhythmia Any
             history of venous thromboembolism including deep venous thrombosis or pulmonary
             embolism.

          -  Uncontrolled hypertension (diastolic blood pressure >90 mm Hg; systolic >140 mm Hg).
             Patients with hypertension should be under treatment on study entry to effect blood
             pressure control.

          -  Taking medications that are known to be associated with torsades de pointes.

          -  Taking any medications or herbal supplements that are known to be strong inhibitors of
             CYP3A4 within at least 14 days before the first dose of ponatinib.

          -  Creatinine levels > 2.5mg/dl or glomerular filtration rate (GFR) < 20 ml/min or
             proteinuria >3.5 g/day.

          -  Gastrointestinal (GI) function impairment, or a GI disease that may significantly
             alter the absorption of study drugs.

          -  Patients who are currently receiving treatment with any of the medications with
             potential to prolong QT interval (listed in Appendix 4) if the medications cannot be
             either discontinued or switched to a different medication prior to starting study
             drug.

          -  Patients who have received any investigational drug ≤ 4 weeks.

          -  Patients who have undergone major surgery ≤ 2 weeks prior to starting study drug or
             who have not recovered from side effects of such therapy.

          -  Patients who are pregnant or breast feeding and adults of reproductive potential not
             employing an effective method of birth control (women of childbearing potential must
             have a negative serum pregnancy test within 48 hrs. prior to administration of
             Ponatinib). Postmenopausal women must be amenorrheic for at least 12 months to be
             considered of non-childbearing potential. Male and female patients must agree to
             employ an effective barrier method of birth control throughout the study and for up to
             4 months following discontinuation of study drugs.

          -  Patients with a history of another primary malignancy that is currently clinically
             significant or currently requires active intervention.

          -  Patients unwilling or unable to comply with the protocol