Inclusion Criteria:

          -  1) histologically confirmed (patients not receiving a single sputum cytology
             diagnosis) non-small cell lung cancer patients,with wild-type EGFR and ALK-negative;
             2) According to IASLC2009 new TNM staging of lung cancer stage ⅢB or Ⅳ, previously
             untreated or relapsed after 1 year of lung cancer resection; 3) have at least one
             evaluable lesions,according to version 1.1 of the standard in accordance with a
             judgment RECIST(longest diameter on a spiral CT at least 10mm,on a regular CT longest
             diameter at least 20mm); 4) Male or female, aged 18 to 75 years; 5) ECOG PS 0 or 1; 6)
             expected survival at least 3 months; 7) adequate hematological function: absolute
             neutrophil count (ANC) at least 2×10^9/L and platelet count at least 100×10^9/L and
             hemoglobin at least 9 g/dL; 8) adequate liver function: total bilirubin less than
             upper limit of normal (ULN); AST and ALT less than 2.5 times upper limit of normal
             (ULN); alkaline phosphatase less than 5 times the upper limit of normal (ULN); 9)
             adequate renal function: serum creatinine less than upper limit of normal (ULN) or
             calculated creatinine clearance at least 60 mL/min; 10) ECG is normal, there is no
             non-healing wounds on the body; 11) had not received previous treatment anticancer
             drugs, or had only received for previous non-metastatic tumors adjuvant or neoadjuvant
             chemotherapy, but when you start to study treatment has ended more than 6 months; 12)
             have conducted previous surgery patients required to study treatment was started more
             than four weeks, and the patient had recovered; 13) have an intact uterus in women
             prior to enrollment in the study must have a negative pregnancy test result (unless it
             is already 24 months of amenorrhea) within 28 days. If the pregnancy test from the
             first administration more than seven days, urine pregnancy test is required for
             authentication (less than 7 days before the first dose); 14) previous to biological
             agents, particularly E.coli genetically engineered products without serious allergic
             reactions; 15) signed informed consent.

        Exclusion Criteria:

          -  1) pregnancy, breast-feeding women, or female patients of childbearing potential but
             did not take contraceptive measures;2) existing severe acute infection and is not
             controlled; or purulent and chronic infection, delayed healing wounds; 3) the original
             severe heart disease, including congestive heart failure, uncontrolled high-risk
             arrhythmias, unstable angina, myocardial infarction, severe heart valve disease and
             resistant hypertension; 4) suffering from neurological and psychiatric diseases or
             mental disorders is not easy to control, poor compliance, and can not be described
             with treatment responders; primary brain or central nervous metastasis disease has not
             been controlled, with significant cranial hypertension or neuropsychiatric symptoms;
             5) have bleeding tendencies; 6) other researchers believe that patients should not
             participate in the present trial.