This is a Randomized, Double-blind, Multi-center, Multi-national Trial to Evaluate the
statistical equivalence of efficacy, safety and immunogenicity of SAIT101 Versus Rituximab as
a First-line Immunotherapy Treatment in asymptomatic patients with Low Tumor Burden
Follicular Lymphoma. Patients will be randomized in a 1:1 ratio to receive study drug once a
week for 4 weeks, and will then be followed up for up to 52 weeks after the first dose.
Randomization will be stratified by inclusion in the PK/PD sub-population and Follicular
lymphoma international prognostic index 2 (FLIPI-2) score.
Visits are scheduled at Weeks 1, 2, 3, and 4 (study drug infusion visits), and then at Weeks
5, 12, 20, 28, 36, and 52 (i.e., End of Study [EOS]). Efficacy response assessments will be
performed at Weeks 12 and 28, while safety assessments will continue until EOS.
The primary objectives is To compare the efficacy of SAIT101 with rituximab licensed in the
European Union (hereafter designated MabThera®, brand name in EU) when administered as a
first-line immunotherapy in patients with low tumor burden follicular lymphoma (LTBFL) and
the secondary objectives isTo evaluate SAIT101 versus MabThera® with respect to safety and
tolerability, immunogenicity and Pharmacokinetics (PK)/Pharmacodynamics (PD) in a
sub-population of patients.
1. Patients with histologically-confirmed Low Tumor Burden Follicular Lymphoma, without B
symptoms, Ann Arbor stage II to IVA NHL (CD20+ FL of Grades 1, 2, or 3a)
2. Low tumor burden according to GELF criteria defined as:
- Normal serum lactate dehydrogenase (LDH)
- No mass ≥7 cm.
- Less than 3 nodal sites, each with diameter >3 cm
- No systemic or B symptoms (fever >38°C for 3 consecutive days; recurrent,
drenching night sweats; unintentional weight loss exceeding 10% body weight in
the last 6 months.
- No splenomegaly ≥16 cm by CT scan.
- No risk of vital organ compression.
- No pleural or peritoneal serous effusion.
- No leukemic phase >5,000/µL circulating tumor cells.
- No cytopenias (defined as platelets <100,000/mm3, hemoglobin <10 g/dL, or
absolute neutrophil count <1,500/mm3).
3. Patients not previously treated for their FL, including any previous treatment for FL
under clinical trials except localized radiation therapy for previous limited stage
1. Previous treatment with any chemotherapy and/or rituximab or other monoclonal
2. Prior radiotherapy completed <28 days before study enrollment.
3. Anticipated need for concomitant administration of any other experimental drug, or a
concomitant chemotherapy, anticancer hormonal therapy, radiotherapy, or immunotherapy
during study participation.
4. Concomitant disease which requires continuous therapy with corticosteroids at doses
equivalent to prednisolone >20 mg/day.
5. Transformation to high-grade lymphoma secondary to previously untreated low-grade
6. Prior or concomitant malignancies within 5 years prior to screening, with the
exceptions of non-melanoma skin cancer, adequately treated carcinoma in situ of the
cervix, adequately treated breast cancer in situ, and localized prostate cancer stage
T1c, provided that the patient underwent curative treatment and remains relapse free.
7. Patients with a body surface area >3.0 m2.
8. Major surgery (excluding lymph node biopsy) within 28 days prior to randomization.
9. Primary or secondary immunodeficiency (history of, or currently active), including
known history of human immunodeficiency virus (HIV) infection or positive test at
10. Acute, severe infection (e.g., sepsis and opportunistic infections), or active,
chronic or persistent infection that might worsen with immunosuppressive treatment
(e.g., herpes zoster).
11. Positive serological test for hepatitis B surface antigen (HBsAg), hepatitis B core
antibody (HBcAb) or hepatitis C serology.
12. Confirmed current active tuberculosis (TB)
13. Central nervous system (CNS) or meningeal involvement, or cord compression by the
lymphoma; history of CNS lymphoma
14. History of a severe allergic reaction or anaphylactic reaction to a biological agent
or history of hypersensitivity to any component of the trial drug (e.g.,
hypersensitivity or allergy to murine products).
15. Patients who have significant cardiac disease, including but not limited to history of
congestive heart failure (New York Heart Association Class III/IV; see Appendix 7),
unstable angina, or uncontrolled cardiac arrhythmia.
16. Uncontrolled or severe hypertension, or cerebrovascular disease.
17. Serious underlying medical conditions that, per the Investigator's discretion, could
impair the ability of the patient to participate in the trial
18. Any other co-existing medical or psychological condition(s) that will preclude
participation in the study or compromise ability to give informed consent and/or
comply with study procedures.
19. Treatment with any investigational medicinal product (IMP) within 4 weeks prior to
initiation of 1st infusion of study drug, or treatment with a drug that has not
received regulatory approval for any indication within 4 weeks or a minimum of 5
half-lives, whichever is longer, of the 1st infusion of study drug.
20. Receipt of a live/attenuated vaccine within 6 weeks prior to the screening visit.
21. Females who are pregnant, breastfeeding, or planning a pregnancy during the treatment
period or within 12 months after the last infusion of study drug.
22. Patients who are investigational site staff members directly involved in the conduct
of the trial, and their family members, site staff members otherwise supervised by the
investigator, or patients who are Archigen employees directly involved in the conduct
of the trial.