Inclusion Criteria:

          -  Patients with SCCHN who are planned for surgical resection and in the opinion of the
             surgeon are able to safely undergo tissue biopsy plus intratumoral (IT) injection in
             advance, with special consideration given to risk of occlusion or compression of
             airway or major vessels in the neck, secondary to tumor swelling, or erosion into a
             major vessel in the case of necrosis.

          -  Age 18 years or above with ability to give informed consent, comply with the protocol
             and sign a study-specific consent document. Patients with history of psychiatric
             illness must be judged by the investigator as able to understand the investigational
             nature and risks associated with the therapy.

          -  Any Eastern Cooperative Oncology Group (ECOG) performance status deemed suitable by
             investigator for requirements of study, to potentially include incisional office
             biopsy of lesion, or image guided multiple 18g core needle biopsies (5 minimum) by
             interventional radiology, followed immediately by direct injection of lesion with
             drug.

          -  Patients must have blood test results within protocol-specified parameters

          -  Men must agree to not attempt to become a new father for a total of 165 days
             post-treatment completion

          -  Women must agree not to become pregnant for a total of 105 days post treatment
             completion

        Exclusion Criteria:

          -  Any clinical factors such as bleeding, active infection, colitis history or
             psychiatric factors that in the judgment of the investigator would preclude safe
             participation and compliance with study procedures.

          -  Need for chronic maintenance oral steroids ≥ 20mg prednisone daily equivalent; inhaled
             steroids are acceptable.

          -  History of or current active autoimmune diseases, [e.g. including but not limited to
             inflammatory bowel diseases (IBD), rheumatoid arthritis, autoimmune thyroiditis,
             autoimmune hepatitis, systemic sclerosis (scleroderma and variants), systemic lupus
             erythematosus, autoimmune vasculitis, autoimmune neuropathies (such as Guillain-Barre
             syndrome), which in the judgment of the investigator pose an active and significant
             risk. Vitiligo and adequately controlled endocrine deficiencies such as hypothyroidism
             are not exclusionary.]

          -  Infectious diseases including human immunodeficiency virus (HIV), Hepatitis B virus
             (HBV) and hepatitis C virus (HCV).

          -  Patients who have had a history of acute diverticulitis, intra-abdominal abscess, GI
             obstruction and abdominal carcinomatosis which are known risk factors for bowel
             perforation, and in the judgment of the investigator still pose an active risk.