Inclusion Criteria:

          -  Advanced or metastatic cancer.

          -  Able to swallow tablets.

          -  For Part B, you will need to have colon cancer or non-small cell lung (NSCLC) cancer
             with KRAS and/or BRAF mutations.

          -  Discontinued all previous treatments for cancer and recovered from the acute effects
             from the therapy.

        Exclusion Criteria:

          -  Active infection (fungal, viral, or bacterial).

          -  Active cancer in your brain or spinal cord.

          -  Acute or chronic leukemia.

          -  Serious heart condition.

          -  Disease that requires immunosuppressant therapy.

          -  Diagnosis of inflammatory bowel disease.

          -  Major small bowel resection that interferes with your body's ability to absorb the
             oral medicine.

          -  Participated in other clinical trials investigating prexasertib or ralimetinib.

          -  Pregnant or breastfeeding.

          -  Other pre-existing conditions or medical history which your doctor will explain to
             you.