Inclusion Criteria:

          -  Signed informed consent form;

          -  Aged 18-65 years;

          -  ECOG physical condition is 0 or 1;

          -  Life expectancy greater than 12 weeks;

          -  Diagnosed with histologically or cytologically-confirmed, standard treatment is
             ineffective (disease progresses after treatment) or HER2-positive, locally advanced or
             metastatic malignant solid tumor patients who cannot tolerate standard therapy, cannot
             receive or do not have standard therapy;

          -  Human epidermal growth factor receptor 2 (HER2)-positive as measured either by
             immunohistochemistry (IHC 2+ and by fluorescence in situ hybridization (FISH) or by
             immunohistochemistry (3+);

          -  Patients with measurable and appreciable tumor lesions according to Response
             Evaluation Criteria in Solid Tumors (RECIST 1.1);

          -  Adequate organ function as defined by the following criteria:

               -  absolute neutrophil count(ANC) >= 1.5 x 10(9)/L;

               -  platelets>=100*10(9)/L;

               -  Total serum bilirubin <=1.5*ULN;

               -  serum aspartate transaminase (AST) and serum alanine transaminase (ALT)
                  <=2.5*upper limit of normal (ULN), or AST and ALT<=5*ULN with hepatic metastasis;

               -  Serum creatinine clearance rate >=45ml/min;

               -  international normalized ratio (INR) and activated partial thromboplastin time
                  (APTT) must be less than or equal to 1.5 times the upper limit of the normal
                  range (ULN);

          -  Women of child-bearing potential and men must agree to use adequate contraception
             (e.g. condoms, implants, injectables, combined oral contraceptives, some intrauterine
             devices [IUDs], complete sexual abstinence, or sterilized partner) prior to study
             entry and during the period of therapy and for 30 days after the last dose of study
             drug;

          -  Left ventricular ejection fraction (LVEF) >= 50%.

        Exclusion Criteria:

          -  Current pregnancy or lactation;

          -  Received anti-tumor treatment 4 weeks before study administration, including
             chemotherapy, radiotherapy, hormone therapy, biological therapy or immunotherapy,
             except the following: Gonadotropin-releasing hormone (GnRH) antagonistic therapy for
             prostate cancer and Hormone replacement therapy;

          -  Major surgery within 4 weeks of first dose of study drug and not fully recovered;

          -  Receiving palliative radiation therapy for bone metastases if administered <= 2 weeks
             prior to first study treatment;

          -  Toxicity of previous anti-tumor treatment has not recovered to CTCAE [version 4.0] 0-1
             (with exception of alopecia);

          -  Participated in other clinical drug studies within 4 weeks;

          -  Hypersensitivity or delayed allergic reaction to certain components of RC48-ADC or
             similar drugs;

          -  According to the judgment of the investigator, a clinically significant active
             infection;

          -  A history of immunodeficiency, including a positive HIV test, or other acquired,
             congenital immunodeficiency diseases, or a history of organ transplantation;

          -  Uncontrollable systemic diseases including diabetes, hypertension, lung Fibrosis,
             acute lung disease, interstitial lung disease, etc.;

          -  Congestive heart failure with grade 2 or higher (including grade 2) by the New York
             Institute of Cardiology (NYHA) of the United States in the history of diseases such as
             acute myocardial infarction, unstable angina, stroke, or transient ischemic attack
             within 6 months before enrollment;

          -  Insufficient adherence to participate in this clinical study;

          -  Treated with Herceptin (Trastuzumab) within 60 days before the trial;

          -  Have received systemic steroid therapy for a long time ( short-term users who
             discontinue medication> 2 weeks can be selected);

          -  Uncontrolled primary or metastatic tumor of brain;

          -  Peripheral neuropathy with grade>= 2;

          -  People with a history of mental illness that is difficult to control.