Inclusion Criteria:

          -  Male or female patients with diagnosis of CP-CML with cytogenetic confirmation of Ph+
             chromosome [t(9;22)(q34;q11)].

          -  Ph negative cases or patients with variant translocations who are BCR-ABL positive in
             multiplex PCR4 will be also considered eligible.

          -  ECOG performance status ≤2.

          -  Age ≥ 18 years old (no upper age limit is given)

          -  Serum levels of potassium, magnesium and total calcium within the normal limits (≥LLN
             [lower limit of normal] and ≤ULN [upper limit of normal]). Correction of electrolytes'
             levels with supplements to meet enrolment criteria is allowed.

          -  AST and ALT ≤2.5 x ULN or 5.0 x ULN if considered due to leukemia

          -  Alkaline phosphatase ≤2.5 x ULN unless considered due to leukemia

          -  Total bilirubin ≤1.5 x ULN, except known Gilbert disease

          -  Serum creatinine ≤2 x ULN

          -  Written informed consent prior to any study procedures being performed.

        For 1st-line patients:

        • Pre-treatment with hydroxyurea up to 6 months and imatinib or dasatinib for duration of
        up to 4 weeks is permitted.

        For ≥ 2nd-line patients:

        • Patients with treatment failure according to the 2013 ELN Recommendations criteria3 or
        treatment intolerance as assessed by the investigator after prior treatment with TKIs other
        than dasatinib (imatinib, nilotinib, bosutinib, ponatinib).

        Exclusion Criteria:

          -  Previous allogeneic stem cell transplantation (AlloSCT)

          -  Known impaired cardiac function, including any of the following:

               -  Congenital long QT syndrome

               -  History of or presence of clinically significant ventricular or atrial
                  tachyarrhythmia

               -  QTc >450 msec on screening ECG

               -  Myocardial infarction within 6 months prior to starting therapy

          -  Other clinical significant heart disease (e.g. unstable angina pectoris, congestive
             heart failure)

          -  Acute or chronic viral hepatitis with moderate or severe hepatic impairment
             (Child-Pugh scores >6), even if controlled

          -  Other concurrent uncontrolled medical conditions (e.g., active or uncontrolled
             infections, acute or chronic liver and renal disease) that could cause unacceptable
             safety risks or compromise compliance with the protocol

          -  Impaired gastrointestinal function or disease that may alter the absorption of study
             drug (e.g., ulcerative disease, uncontrolled nausea, vomiting and diarrhea,
             malabsorption syndrome, small bowel resection or gastric by-pass surgery)

          -  Concomitant medications known to be strong inducers or inhibitors of the CYP450
             isoenzyme CYP3A4

          -  Patients who have undergone major surgery ≤2 weeks prior to starting study drug or who
             have not recovered from side effects of such therapy

          -  Patients who are pregnant or breastfeeding or women of reproductive potential not
             employing an effective method of birth control. Women of childbearing potential must
             have a negative serum pregnancy test within 14 days prior to administration of
             dasatinib. Post-menopausal women must be amenorrheic for at least 12 months in order
             to be considered of non-childbearing potential. Male and female patients must agree to
             employ an effective method of birth control throughout the study and for up to 3
             months following discontinuation of study drug

          -  Known diagnosis of human immunodeficiency virus (HIV) infection (HIV testing is not
             mandatory)

          -  Active autoimmune disorder, including autoimmune hepatitis

          -  Known serious hypersensitivity reactions to dasatinib

          -  Patients with a history of another primary malignancy that is currently clinically
             significant or currently requires active intervention

          -  Patients unwilling or unable to comply with the protocol.