Most patients with locally advanced or metastatic tumors succumb to their disease. Thus,
there is a substantial need for novel therapeutic strategies to improve the outcome for
patients with advanced or metastatic melanoma. Targeting the the Ras/Raf signalling pathway
by BRAF and MEK inhibition as well as targeting immunologic checkpoint control with an
antiPD-L1 antibody have emerged as treatment option.
In this study the best timing for sequential use of both treatment options (BRAF/MEK
inhibition and antiPD-L1 antibody) in patients with unresectable or metastatic BRAFV600
mutant melanoma will be assessed.
At this time there is no experience concerning the sequencing strategy when using the two
effective therapeutical approaches as targeting the Ras/Raf signalling pathway by BRAF and
MEK inhibition or targeting immunologic checkpoint control with an antiPD-L1 antibody.
This is a prospective, open, multicenter, randomized phase II study in patients with
unresectable or metastatic BRAFV600 mutant melanoma. In this study the scheduling of the
treatment with a combined BRAF/MEK inhibition and the treatment with an anti-PD-L1 antibody
will be assessed.
After a 3 months run-in period with vemurafenib and cobimetinib, all patients who did not
show disease progression or treatment interruption for more than 28 days during run-in phase
will be randomized in a 1:1 ratio:
- either to proceed vemurafenib and cobimetinib until disease progression and subsequently
cross-over to atezolizumab treatment until disease progression (Arm A).
- or to receive the anti-PD-L1 antibody atezolizumab until disease progression and
subsequently cross-back to vemurafenib and cobimetinib until disease progression (Arm
B). In a translational research program tumor tissue, blood plasma and peripheral blood
mononuclear cell will be analyzed to evaluate the biologic effects of treatment sequence
on the molecular profile and biomarker expression in tissue and plasma.
Inclusion Criteria:
- Be willing and able to provide written informed consent for the trial.
- Male or female patient being ≥18 years of age on day of signing informed consent.
- Histologically confirmed diagnosis of locally advanced, unresectable or metastatic
melanoma AJCC (unresectable stage IIIB, IIIC, IVM1a, IVM1b, or IVM1c) without active
or untreated brain metastases; all known CNS lesions must have been treated with
stereotactic therapy or surgery at least 4 weeks prior to the first dose of trial
treatment AND the patient must be without evidence of clinical or radiographic disease
progression in the CNS for at least 4 weeks prior to the first dose of trial treatment
and any neurologic symptoms must have returned to baseline, the patient must have no
evidence of new or enlarging brain metastases, and the patient must not have used
steroids for at least 3 weeks prior to trial treatment.
- No previous therapy for the advanced or metastatic stage. Prior adjuvant therapy is
permitted (e.g. Interferon, Interleukin-2-therapy, chemo- or radiotherapy). Prior
adjuvant therapy has to be terminated (last dose) at least 28 days before enrolment.
Patients who are in follow-up period of a clinical trial in adjuvant setting and
progressing may be enrolled / randomized.
- Measurable disease, i.e., present with at least one measurable lesion per RECIST,
version 1.1, for the definition of a measureable lesion.
- Presence of BRAF mutation (V600) in tumor tissue.
- Performance status of 0 or 1 on the ECOG Performance Scale.
- Adequate organ function.
- Adequate cardiac function.
- Able to take oral medications.
- Female subject of childbearing potential should have a negative pregnancy test within
72 hours prior to receiving the first dose of study medication.
- Female patients of childbearing potential and male patients with partners of
childbearing potential must agree to always use a highly effective form of
contraception according to CTFG during the course of this study and for at least 6
months after completion of study therapy.
Exclusion Criteria:
- Use of any investigational or non-registered product within the 30 days before
registration.
- Diagnosis of immunodeficiency or receiving systemic steroid therapy or any other form
of immunosuppressive therapy within 7 days prior to study Day 1.
- Prior therapy with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CD137, or anti-Cytotoxic
T-lymphocyte-associated antigen-4 (CTLA-4) antibody (including ipilimumab or any other
antibody or drug specifically targeting T-cell co-stimulation or checkpoint pathways).
- Prior therapy with a BRAF inhibitor (including but not limited to vemurafenib,
dabrafenib, encorafenib and / or MEK inhibitor
- Prior major surgery.
- Known additional malignancy that is progressing or requires active treatment within 5
years prior to the study.
- Known active central nervous system (CNS) metastases and/or carcinomatous meningitis.
- History of leptomeningeal metastases.
- History or current evidence of central serous retinopathy (CSR) or retinal vein
occlusion (RVO) or predisposing factors to RVO or CSR.
- History of retinal degenerative disease.
- History of allogenic bone marrow transplantation or organ transplantation.
- History of Gilbert's syndrome.
- Impaired cardiovascular function or clinically significant cardiovascular diseases.
- Uncontrolled arterial hypertension despite medical treatment.
- Impairment of gastrointestinal function or gastrointestinal disease.
- Evidence of interstitial lung disease or active, non-infectious pneumonitis.
- Active infection requiring systemic therapy.
- Positive test for Human Immunodeficiency Virus (HIV).
- Positive test for Hepatitis B or Hepatitis C.
- Known hypersensitivity reaction to any of the components of study treatment.
- Medical, psychiatric, cognitive or other conditions, including known alcohol or drug
abuse.
- Patients having received a live, attenuated vaccine within 4 weeks prior to the first
dose of trial treatment.
- Legal incapacity or limited legal capacity.
