Inclusion Criteria:

          -  Measureable disease according to RECIST Version 1.1

          -  Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

          -  Minimum age of 18 years

          -  Adequate hematological, hepatic and renal function

          -  Written consent on an Institutional Review Board-approved informed consent form prior
             to any study-specific evaluation

          -  Histologically or cytologically confirmed diagnosis of one of the following:

               1. Metastatic or unresectable locally advanced NSCLC with documented evidence that
                  the tumor harbors one of the two common EGFR mutations known to be associated
                  with EGFR tyrosine kinase inhibitor (TKI) sensitivity (exon 19 deletion, L858R),
                  either alone or in combination with other EGFR mutations, determined by PCR-based
                  testing of the tumor tissue or plasma sample, and without prior exposure to an
                  EGFR-TKI therapy; OR

               2. Metastatic or unresectable locally advanced NSCLC:

                    1. with documented evidence that the tumor harbors an EGFR mutation known to be
                       associated with EGFR TKI sensitivity (including G719X, exon 19 deletion,
                       L858R, L861Q); and

                    2. with evidence of radiological disease progression while on a previous
                       continuous treatment with a first-generation EGFR TKI. In addition, other
                       lines of therapy may have been given. All patients must have evidence of
                       radiological disease progression on or following the last treatment
                       administered; and

                    3. with documented evidence of EGFR T790M mutation determined by PCR-based
                       testing of the tumor tissue or plasma sample following disease progression
                       on most recent treatment regimen (irrespective of whether this is EGFR TKI
                       or chemotherapy).

        Exclusion Criteria:

          -  Active second malignancy or other prior malignancy treated with chemotherapy less than
             or equal to 6 months prior to treatment with CK-101

          -  History of, or evidence of clinically active, interstitial lung disease

          -  Brain metastases unless asymptomatic, stable and not requiring steroids for at least 2
             weeks

          -  Treatment with prohibited medications

          -  Any toxicity related to prior treatment must have resolved to Grade 1 or less, with
             the exception of alopecia and Grade 2, prior platinum-therapy related neuropathy

          -  Certain cardiac abnormalities or history

          -  Non-study related surgical procedures less than or equal to 14 days prior to CK-101
             administration

          -  Females who are pregnant or breastfeeding.

          -  Refusal to use adequate contraception for fertile patients (females and males)

          -  Presence of any serious or unstable concomitant systemic disorder incompatible with
             the clinical study

          -  Refractory nausea and vomiting, chronic gastrointestinal diseases, inability to
             swallow the formulated product or previous significant bowel resection