Clinical Trials /

Guadecitabine and Atezolizumab in Treating Patients With Advanced Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia That Is Refractory or Relapsed

NCT02935361

Description:

This phase I/II trial studies the side effects and best dose of guadecitabine when given together with atezolizumab and to see how well they work in treating patients with myelodysplastic syndrome or chronic myelomonocytic leukemia that has spread to other places in the body and has come back or does not respond to treatment. Guadecitabine may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as atezolizumab, may interfere with the ability of cancer cells to grow and spread. Giving guadecitabine and atezolizumab may work better in treating patients with myelodysplastic syndrome or chronic myelomonocytic leukemia.

Related Conditions:
  • Chronic Myelomonocytic Leukemia
  • Myelodysplastic Syndromes
Recruiting Status:

Recruiting

Phase:

Phase 1/Phase 2

Trial Eligibility

Document

Title

  • Brief Title: Guadecitabine and Atezolizumab in Treating Patients With Advanced Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia That Is Refractory or Relapsed
  • Official Title: A Phase I/II Multicenter Study Combining Guadecitabine, a DNA Methyltransferase Inhibitor, With Atezolizumab, an Immune Checkpoint Inhibitor, in Patients With Intermediate or High-Risk Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia

Clinical Trial IDs

  • ORG STUDY ID: 9L-16-3
  • SECONDARY ID: NCI-2016-01233
  • SECONDARY ID: 9L-16-3
  • SECONDARY ID: P30CA014089
  • NCT ID: NCT02935361

Conditions

  • Chronic Myelomonocytic Leukemia
  • Myelodysplastic Syndrome
  • Recurrent Acute Myeloid Leukemia With Myelodysplasia-Related Changes

Interventions

DrugSynonymsArms
AtezolizumabMPDL 3280A, MPDL 328OA, MPDL-3280A, MPDL3280A, MPDL328OA, RG7446, RO5541267, TecentriqTreatment (guadecitabine, atezolizumab)
GuadecitabineDNMT inhibitor SGI-110, S110, SGI-110Treatment (guadecitabine, atezolizumab)

Purpose

This phase I/II trial studies the side effects and best dose of guadecitabine when given together with atezolizumab and to see how well they work in treating patients with myelodysplastic syndrome or chronic myelomonocytic leukemia that has spread to other places in the body and has come back or does not respond to treatment. Guadecitabine may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as atezolizumab, may interfere with the ability of cancer cells to grow and spread. Giving guadecitabine and atezolizumab may work better in treating patients with myelodysplastic syndrome or chronic myelomonocytic leukemia.

Detailed Description

      PRIMARY OBJECTIVES:

      I. To identify a safe dose of guadecitabine in combination with atezolizumab and to assess
      the safety and tolerability of the combination in patients with myelodysplastic syndrome
      (MDS) who are refractory to or have lost their confirmed response to one or more
      hypomethylating agents (HMAs) and in patients with newly diagnosed MDS.

      II. To evaluate the efficacy of guadecitabine in combination with atezolizumab for the
      treatment of patients with MDS who are refractory to or have lost their confirmed response to
      one or more HMAs.

      III. To evaluate the efficacy of guadecitabine in combination with atezolizumab for the
      treatment of patients with newly diagnosis MDS.

      SECONDARY OBJECTIVES:

      I. To measure the impact of the combination of guadecitabine and atezolizumab on overall
      survival among patients with relapsed/refractory MDS.

      II. To measure the impact of the combination of guadecitabine and atezolizumab on overall
      survival among patients with treatment-naive MDS.

      III. To evaluate the impact of the combination of guadecitabine and atezolizumab on the
      duration of response in patients with relapsed/refractory MDS and treatment-naive MDS.

      IV. To evaluate the impact of the combination of guadecitabine and atezolizumab on
      transfusion-dependence among patients with relapsed/refractory and treatment-naive MDS.

      TERTIARY OBJECTIVES:

      I. To determine the baseline expression/methylation of programmed cell death protein 1 (PD-1)
      in T cells among patients with relapsed, refractory and treatment-naive MDS.

      II. To quantify the impact of combination therapy with guadecitabine and atezolizumab on PD-1
      expression/methylation in T cells.

      III. To correlate response with expression/methylation of PD-1 by T cells and with expression
      of programmed cell death-ligand 1 (PD-L1) in the bone marrow of patients with MDS treated
      with guadecitabine and atezolizumab.

      IV. To investigate the expression of tumor antigens on MDS blasts during combination therapy
      with guadecitabine and atezolizumab V. To investigate the specific T-cell subsets in MDS
      blood and bone marrow during combination therapy with guadecitabine and atezolizumab.

      VI. To investigate the specific antigens (epitopes) which are recognized by T-cells in MDS
      blood and bone marrow during combination therapy with guadecitabine and atezolizumab.

      OUTLINE: This is a phase I, dose-escalation study of guadecitabine followed by a phase II
      study.

      Patients receive guadecitabine subcutaneously (SC) on days 1-5 and atezolizumab intravenously
      (IV) over 30-60 minutes on days 8 and 22. Courses repeat every 28 days for up to 24 months in
      the absence of disease progression or unacceptable toxicity.

      After completion of study treatment, patients are followed up for 30 or 90 days and every 6
      months thereafter.
    

Trial Arms

NameTypeDescriptionInterventions
Treatment (guadecitabine, atezolizumab)ExperimentalPatients receive guadecitabine SC on days 1-5 and atezolizumab IV over 30-60 minutes on days 8 and 22. Courses repeat every 28 days for up to 24 months in the absence of disease progression or unacceptable toxicity.
  • Atezolizumab
  • Guadecitabine

Eligibility Criteria

        Inclusion Criteria:

          -  Phase I: Adult subjects with advanced MDS requiring therapy who were previously
             treated with either azacitidine or decitabine for at least 4 cycles and deemed to have
             failed therapy due to progression of disease using International Working Group (IWG)
             criteria ("refractory") or losing their previously documented response to the therapy
             ("relapsed")

          -  Phase II: Adult subjects with advanced MDS requiring therapy who were previously
             treated with either azacitidine or decitabine for at least 4 cycles and deemed to have
             failed therapy due to progression of disease using IWG criteria ("refractory") or
             losing their previously documented response to the therapy ("relapsed")

          -  MDS should be classified as:

               -  Intermediate 1-risk or higher risk according to the international prognostic
                  scoring system (IPSS) or revised IPSS

               -  Chronic myelomonocytic leukemia (CMML)

          -  During the 8 weeks prior to inclusion in study, subjects must have a baseline bone
             marrow examination including all of the following:

               -  Cytomorphology to confirm bone marrow blasts;

               -  Cytogenetics; AND

               -  Eastern Cooperative Oncology Group (ECOG) status 0-2

          -  Subject is able to understand and willing to comply with protocol requirements and
             instructions

          -  Subject has signed and dated informed consent

          -  Total bilirubin (except for Gilbert's syndrome) =< 2.5 x upper limit of normal (ULN)

          -  Aspartate aminotransferase (ALT) and alanine aminotransferase (AST) =< 3 x ULN

          -  Creatinine =< 2.5 x ULN

          -  For women of childbearing potential: agreement to remain abstinent (refrain from
             heterosexual intercourse) or use contraceptive methods that result in a failure rate
             of < 1% per year during the treatment period and for at least 90 days after the last
             dose of atezolizumab

               -  A woman is considered to be of childbearing potential if she is postmenarcheal,
                  has not reached a postmenopausal state (>= 12 continuous months of amenorrhea
                  with no identified cause other than menopause), and has not undergone surgical
                  sterilization (removal of ovaries and/or uterus)

               -  Examples of contraceptive methods with a failure rate of < 1% per year include
                  bilateral tubal ligation, male sterilization, proper use of hormonal
                  contraceptives that inhibit ovulation, hormone-releasing intrauterine devices,
                  and copper intrauterine devices

               -  The reliability of sexual abstinence should be evaluated in relation to the
                  duration of the clinical trial and the preferred and usual lifestyle of the
                  patient; periodic abstinence (e.g., calendar, ovulation, symptothermal, or
                  postovulation methods) and withdrawal are not acceptable methods of contraception

          -  For men: agreement to remain abstinent (refrain from heterosexual intercourse) or use
             contraceptive measures, and agreement to refrain from donating sperm, as defined
             below:

               -  With female partners of childbearing potential, men must remain abstinent or use
                  a condom plus an additional contraceptive method that together result in a
                  failure rate of < 1% per year during the treatment period and for at least 120
                  days after the last dose of guadecitabine; men must refrain from donating sperm
                  during this same period

               -  With pregnant female partners, men must remain abstinent or use a condom during
                  the treatment period and for at least 30 days after the last dose of
                  guadecitabine to avoid exposing the embryo

               -  The reliability of sexual abstinence should be evaluated in relation to the
                  duration of the clinical trial and the preferred and usual lifestyle of the
                  patient; periodic abstinence (e.g., calendar, ovulation, symptothermal, or
                  postovulation methods) and withdrawal are not acceptable methods of contraception

          -  Women of childbearing potential (WOCBP) must have a negative serum test (minimum
             sensitivity 25 IU/L or equivalent units of human chorionic gonadotropin [HCG]) within
             72 hours prior to the start of investigational product

        Exclusion Criteria:

          -  Any active history of a known autoimmune disease; subjects with vitiligo, type 1
             diabetes mellitus, residual hypothyroidism requiring hormone replacement, or
             conditions not expected to recur in the absence of an external trigger are permitted
             to enroll

          -  Subjects with a history of interstitial lung disease; patients requiring continuous
             supplemental oxygen are excluded to avoid possible complications from pneumonitis

          -  History of idiopathic pulmonary fibrosis, organizing pneumonitis (e.g., bronchiolitis
             obliterans), drug-induced pneumonitis, or idiopathic pneumonitis

          -  Patients who are actively receiving any other anticancer therapy

          -  Patients with a history of allergic reactions attributed to compounds of similar
             chemical or biologic composition to HMAs

          -  Patients with a diagnosis of acute myeloid leukemia (AML) not transformed from MDS or
             transformed from MDS with > 30% blasts in bone marrow or white blood cells (WBC) > 25
             x 10^3/L

          -  Patients with short life expectancy (less than 3 months) due to comorbidity other than
             MDS

          -  Female subjects who are nursing or pregnant (positive serum or urine beta-human
             chorionic gonadotropin [B-hCG] pregnancy test)

          -  Patients with current alcohol or drug abuse

          -  Patients who have received treatment with an investigational drug within 30 days
             preceding the first dose of study medication

          -  Patients with uncontrolled inter-current illness including, but not limited to,
             ongoing or active infection, symptomatic congestive heart failure, unstable angina
             pectoris, uncontrolled cardiac arrhythmia, or psychiatric illness/social situations
             that would limit compliance with study requirements

               -  Patients with prior infections must be afebrile for >= 72 hours and completed any
                  antibiotics prior to receiving study drug

               -  In patients who received IV antibiotics for active infection, a washout period of
                  14 days is required prior to initiating study therapy (exception: patients with
                  febrile neutropenia in whom no infectious etiology has been
                  determined/documented)

               -  Patients receiving chronic antimicrobial prophylaxis therapy (e.g. antifungal
                  prophylaxis) may be included in the study provided there is no active infection

          -  Patients infected with hepatitis B, C or human immunodeficiency virus (HIV), unless
             they are on stable and effective antiviral treatment

               -  Serious infection requiring oral or IV antibiotics/antifungals/antivirals and/or
                  hospitalization within 28 days prior to screening

               -  Patients on prophylactic oral antibiotics, antifungals and antivirals due to
                  prolonged neutropenia in the absence of documented infection are eligible

               -  Patients who are treated with IV antibiotics for neutropenic fever, are eligible
                  if no infectious etiology was determined and the last dose of antibiotics was >=
                  7 days from cycle 1, day 1

               -  Patients with a condition requiring systemic treatment with either
                  corticosteroids (> 10 mg daily prednisone equivalent) or other immunosuppressive
                  medications within 14 days of randomization. Inhaled or topical steroids and
                  adrenal replacement steroid doses > 10 mg daily prednisone equivalent, are
                  permitted in the absence of uncontrolled autoimmune disease

          -  Medication-related exclusion criteria

          -  Prior treatment with anti−PD-1, or anti−PD-L1 therapeutic antibody or
             pathway-targeting agents

          -  Prior treatment with anti−cytotoxic T-lymphocyte-associated protein 4 (CTLA-4)
             therapeutic agents (e.g. ipilimumab)

          -  Treatment with systemic immunostimulatory agents (including but not limited to
             interferon [IFN]-alpha or interleukin [IL]-2) within 6 weeks or five half-lives of the
             drug (whichever is shorter) prior to cycle 1, day 1

          -  Treatment with any investigational agent within 4 weeks prior to cycle 1, day 1 (or
             within five half-lives of the investigational product, whichever is longer)

          -  Treatment with systemic immunosuppressive medications (including but not limited to
             prednisone, cyclophosphamide, azathioprine, methotrexate, thalidomide, and anti-tumor
             necrosis factor [anti-TNF] agents) within 2 weeks prior to cycle 1, day 1

          -  Patients who have received acute, low-dose, systemic immunosuppressant medications may
             be enrolled

          -  The use of inhaled corticosteroids and mineralocorticoids (e.g., fludrocortisone) for
             patients with orthostatic hypotension or adrenocortical insufficiency is allowed

          -  History of severe allergic, anaphylactic, or other hypersensitivity reactions to
             chimeric or humanized antibodies or fusion proteins

          -  Patients with prior allogeneic bone marrow transplantation or prior solid organ
             transplantation
      
Maximum Eligible Age:N/A
Minimum Eligible Age:18 Years
Eligible Gender:All
Healthy Volunteers:No

Primary Outcome Measures

Measure:Incidence of dose-limiting toxicities evaluated according to National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 (Phase I)
Time Frame:Up to 56 days
Safety Issue:
Description:Descriptive summaries and analyses of CTCAE 4.0 toxicities that occur will be produced, both by patient and by cycle.

Secondary Outcome Measures

Measure:Incidence of grade 3 or higher adverse events and grade 2 toxicities that do not resolve after 3 weeks assessed by CTCAE 4.0
Time Frame:Up to 8 weeks
Safety Issue:
Description:Descriptive summaries of toxicities that occur will be produced, both by patient and by course.
Measure:Overall response rate (Phase II)
Time Frame:Up to 4 years
Safety Issue:
Description:
Measure:Overall survival
Time Frame:From start of treatment to death from any cause, assessed up to 4 years
Safety Issue:
Description:Will be analyzed using survival analysis methods.
Measure:Percentage of patients who were transfusion-dependent on study entry who become transfusion-independent
Time Frame:Up to 4 years
Safety Issue:
Description:
Measure:Progression free survival
Time Frame:From start of treatment to the first disease progression or recurrence, assessed up to 4 years
Safety Issue:
Description:Will be analyzed using survival analysis methods.
Measure:Time to best response
Time Frame:Up to 4 years
Safety Issue:
Description:Will be analyzed using survival analysis methods.

Details

Phase:Phase 1/Phase 2
Primary Purpose:Interventional
Overall Status:Recruiting
Lead Sponsor:University of Southern California

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