This is an open-label, Phase 1/2 study in subjects with advanced or metastatic solid tumors.
The study has three separate treatment groups where separate epigenetic agents are evaluated
with an immunotherapy combination. Treatment Group A will evaluate the DNA methyltransferase
inhibitor azacitidine in combination with the programmed death receptor-1 (PD-1) inhibitor
pembrolizumab and the indoleamine 2,3-dioxygenase (IDO-1) inhibitor epacadostat; Treatment
Group B will evaluate the bromodomain and extra-terminal (BET) inhibitor INCB057643 with
pembrolizumab and epacadostat; and Treatment Group C will evaluate the lysine-specific
demethylase 1A (LSD1) inhibitor INCB059872 with pembrolizumab and epacadostat. The study will
be divided into 2 parts (Part 1 and 2). Part 1 is a dose-escalation assessment to evaluate
the safety and tolerability of the combination therapies. Once the recommended doses have
been determined, subjects with previously treated NSCLC, microsatellite-stable colorectal
cancer (CRC), head and neck squamous cell carcinoma, urothelial carcinoma, and melanoma will
be enrolled into expansion cohorts in Part 2.
Inclusion Criteria:
- Willingness to provide written informed consent for the study.
- Willingness to undergo a pretreatment and on-treatment tumor biopsy to obtain tumor
tissue.
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
- Part 1: Subjects with histologically or cytologically confirmed advanced or metastatic
solid tumors that have failed prior standard therapy (disease progression; subject
refusal or intolerance is also allowable).
- Part 2:
*Note: Subjects must have failed available therapies that are known to confer clinical
benefit as indicated below, unless they are ineligible, intolerant, or refused
standard treatment.
- Subjects with histologically or cytologically confirmed NSCLC:
- Metastatic (Stage IV) or recurrent NSCLC (according to American Joint Committee
on Cancer 7th edition guidelines) who have had disease progression after
available therapies for advanced or metastatic disease that are known to confer
clinical benefit, been intolerant to treatment, or refused standard treatment.
- Prior systemic regimens must include previously approved therapies, including a
platinum-containing chemotherapy regimen; a tyrosine kinase inhibitor for tumors
with driver mutations; and checkpoint inhibitors where approved.
- Must have disease progression on a prior PD-1-pathway targeted agent.
- Subjects with recurrent (unresectable) or metastatic CRC:
- Have histologically confirmed microsatellite stable (MSS) CRC.
- Stage IV MSS CRC (according to American Joint Committee on Cancer 7th edition
guidelines) who have had disease progression after available therapies for
advanced or metastatic disease that are known to confer clinical benefit, been
intolerant to treatment, or refused standard treatment.
- Prior systemic regimens must include previously approved therapies, including
fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy; an anti-VEGF
therapy (if no contraindication); and if negative for KRAS, NRAS, and BRAF
mutations and no contraindication, an anti-epidermal growth factor receptor
(EGFR) therapy; and progressed after the last administration of approved therapy.
- Subjects with HNSCC:
- Histologically confirmed squamous cell carcinoma of the oral cavity, oropharynx,
hypopharynx, or larynx.
- Carcinomas of the nasopharynx, salivary gland, or nonsquamous cell histology are
excluded.
- Must have received prior treatment with a platinum-based therapy
- Must have had documented disease progression while on a prior PD-1
pathway-targeted agent.
- Subjects with melanoma:
- Histologically or cytologically confirmed melanoma.
- Unresectable Stage III or Stage IV melanoma, as per American Joint Committee on
Cancer staging system not amenable to local therapy.
- Subjects with urothelial carcinoma:
- Histologically or cytologically confirmed urothelial carcinoma of the renal
pelvis, ureter, urinary bladder, or urethra that is transitional cell or mixed
transitional/nontransitional (predominantly transitional) cell type.
- Stage IV locally advanced or metastatic urothelial carcinoma (according to
American Joint Committee on Cancer 7th edition guidelines) with documented
disease progression while on a PD-1 pathway targeted therapy.
Exclusion Criteria:
- Laboratory parameters not within the protocol-defined range.
- Receipt of anticancer medications or investigational drugs within a defined interval
before the first administration of study drug.
- Has not recovered from toxic effects of prior therapy to ≤ Grade 1.
- Active or inactive autoimmune disease or syndrome.
- Active infection requiring systemic therapy.
- Known active central nervous system (CNS) metastases and/or carcinomatous meningitis.
- History or presence of an abnormal ECG that, in the investigator's opinion, is
clinically meaningful.
- Has received a live vaccine within 30 days of planned start of study therapy.
- Prior receipt of an IDO inhibitor.
- Subjects with uncontrolled type I or type II diabetes mellitus (defined as HgbA1c >
8).
- Prior receipt of a BET inhibitor (Treatment Group B only).
- Subjects with a history of bleeding related to cancer under study requiring a medical
intervention (eg, embolization procedure, RBC transfusion, or hospitalization) within
30 days of study enrollment (Treatment Groups B and C only).
- Clinically significant bleeding within 14 days of Cycle 1 Day 1 (Treatment Groups B
and C only).
- Prior receipt of an LSD1 inhibitor including INCB059872 (Treatment Group C only).
