DIAGNOSIS AND INCLUSION CRITERIA:

          1. Patient ≥18 years and < 75 years

          2. Patient ≥18 years and <71 years must have an ECOG ≤1 - Patients ≥71 years and < 75
             years must have an ECOG = 0

          3. Pathologically confirmed high-risk stage III colon adenocarcinoma, restricted to pT4N1
             or pT1-4N2 tumor.

          4. Curative R0 surgical resection.

          5. Patients who have undergone surgery for colon cancer, defined as a tumor location >12
             cm from the anal verge by endoscopy and/or above the peritoneal reflection at surgery
             (high rectum), without gross or microscopic evidence of residual disease after surgery
             with curative intent

          6. Start of study drug treatment has to be performed less than 56 days after surgery.

          7. No prior chemotherapy.

          8. No prior abdominal or pelvic irradiation.

          9. Patient with adequate organ function:

               -  Absolute neutrophil count (ANC) ≥ 2 x 109/L

               -  Haemoglobin ≥9 g/dL

               -  Platelets (PTL) ≥100 x 109/L

               -  AST/ALT ≤2.5 x ULN

               -  Alkaline phosphatase ≤2.5 x ULN

               -  Total Bilirubin ≤1.5 x ULN (Upper Limit of Normal)

               -  Creatinine clearance ≥50 mL/min (Cockcroft and Gault formula)

               -  Kalemia, magnesemia, calcemia ≥ 1 LLN (Lower Limit of Normal)

               -  Carcinoembryogenic antigen (CEA) ≤10ng/mL after surgery (during screening period)

         10. Adequate contraception if applicable.

         11. Patient able and willing to comply with study procedures as per protocol

         12. Patient able to understand and willing to sign and date the written voluntary informed
             consent form at screening visit prior to any protocol-specific procedures

         13. Public or private health insurance coverage

         14. Life expectancy of > or = at 5 years

         15. Uracilemia < 16 ng/ml (only for french centers)

        Exclusion Criteria:

          1. Major surgical procedure, open biopsy or significant traumatic injury within 28 days
             prior to study treatment start. Incompletely healed wounds or anticipation of the need
             for major surgical procedure during the course of the study

          2. Metastatic disease

          3. Presence of inflammatory bowel disease and/or ileus

          4. Known hypersensitivity reaction to any of the components of study treatments.

          5. Pregnancy (absence to be confirmed by β-hCG test) or breast-feeding period

          6. Clinically relevant coronary artery disease or history of myocardial infarction in the
             last 12 months, or high risk of uncontrolled arrhythmia (for men: QTc ≥450 msec, for
             women: QTc ≥470 msec)

          7. Previous malignancy in the last 5 years except curative treated basal cell carcinoma
             of the skin and/or in situ carcinoma of the cervix

          8. Medical, geographical, sociological, psychological or legal conditions that would not
             permit the patient to complete the study or sign informed consent

          9. History or current evidence on physical examination of central nervous system disease
             or peripheral neuropathy ≥ grade 1 Common Toxicity Criteria for Adverse Events (CTCAE)
             v4.03.

         10. Any significant disease which, in the investigator's opinion, would exclude the
             patient from the study.

         11. Patient with a DPD deficiency or UGT1A1 homozygous 7/7; the test should be done for
             all patients before 5-FU administration, according to ANSM communication regarding
             recommendation about high risk of no testing DPD in patient before 5-FU
             administration; (Appendices 8 to 11).

         12. Patients already included in another therapeutic trial involving an experimental drug