The purpose of this study is to evaluate the clinical activity and tolerability of a
combination of obinutuzumab plus venetoclax in patients with relapsed or refractory diffuse
large B-cell lymphoma.
The study will have a 6 patient run-in phase to determine safety and to adjust treatment.
Once the sixth patient has completed 21 days of treatment, withdrawn due to toxicity, or
died, a formal review will be undertaken by the sponsor (AGMT). Enrolment will be halted
until review is completed. If one (1) treatment related death is reported or three (3) or
more patients experience CTC grade 4 events other than neutropenia, anemia, or
thrombocytopenia, the study will be stopped for further recruitment. If the stopping criteria
are not met, enrollment will be continued. A futility analysis will be conducted when the
first 10 patients have been evaluated for response: If at least 2 patients had an objective
response (CR or PR), the study will be continued.
The combination treatment will be repeated for up to 3 cycles. The first response assessment
(including PET-CT) will be performed after the first cycle of obinutuzumab-venetoclax and
patients with at least stable disease (SD) or better will be given another 2 cycles of
therapy and then have assessment after a total of 3 cycles. Patients with complete or partial
remission (CR, PR) after 3 cycles of therapy will either go on to transplant or receive 9
further cycles of the combination therapy (if transplant ineligible). Patients with
progressive disease at any time-point or stable disease after 3 cycles will be taken off
study.
Inclusion Criteria:
- Diffuse large B-cell lymphoma (DLBCL)
- with histologically confirmed relapse within 12 months after having achieved a PR
or CR with initial R-anthracycline containing therapy, or
- with refractoriness to initial R-anthracycline containing therapy (not achieving
at least a partial response)
- Bcl-2 protein expression detected by immunohistochemistry.
- Adequate organ function,
- At least one bi-dimensionally measurable lesion on CT scan defined as > 1.5 cm in its
longest dimension.
- Confirmed availability of archival or freshly biopsied tumor tissue meeting
protocol-defined-specifications prior to study enrolment.
- Eastern Cooperative Oncology Group (ECOG) Performance Status of 0, 1, or 2.
- Adequate hematologic function (unless caused by underlying disease, as established by
extensive bone marrow involvement or as a result of hypersplenism secondary to the
involvement of the spleen by lymphoma per the investigator)
Exclusion Criteria:
- Patient has received any other investigational treatment within 28 days before study
entry.
- Known hypersensitivity to recombinant proteins, murine proteins, or to any excipient
contained in the drug formulation of obinutuzumab or venetoclax.
- DLBCL transformed from other malignancies or CD20 negative DLBCL.
- Radiation, chemotherapy, or immunotherapy or any other anticancer therapy ≤ 4 weeks
prior to Cycle 1 Day 1.
- Ongoing corticosteroid use > 30 mg/day of prednisone or equivalent. Patients who
received corticosteroid treatment with ≤ 30 mg/day of prednisone or equivalent must be
documented to be on a stable dose of at least 4 weeks duration prior to randomization
(Cycle 1 Day 1). Patients may have received a brief (< 7 days) course of systemic
steroids (≤ 100 mg prednisone equivalent) prior to initiation of study therapy for
control of lymphoma-related symptoms.
- ECOG performance status ≥ 3.
- Female patients who are pregnant or breast-feeding.
- Acute or uncontrolled chronic infections.
- Known diagnosis of HIV
- Known cerebral or meningeal disease (HL or any other etiology), including signs or
symptoms of PML.
- Symptomatic neurologic disease compromising normal activities of daily living or
requiring medications.
- Any sensory or motor peripheral neuropathy greater than or equal to Grade 2.
- Known history of any of the following cardiovascular conditions:
- myocardial infarction within 2 years of study entry,
- New York Heart Association (NYHA) Class III or IV heart failure,
- evidence of current uncontrolled cardiovascular conditions, including cardiac
arrhythmias, congestive heart failure (CHF), angina, or electrocardiographic
evidence of acute ischemia or active conduction system abnormalities,
- recent evidence (within 6 months before first dose of study drug) of a
left-ventricular ejection fraction <50% .
- Diagnosed or treated for another malignancy within 3 years before the first dose or
previously diagnosed with another malignancy and have evidence of residual disease.
- Patients with transformed lymphoma.
- Primary CNS lymphoma.
- Vaccination with live vaccines within 28 days prior to treatment.
- History of other malignancy that could affect compliance with the protocol or
interpretation of results (Patients with a history of curatively treated basal or
squamous cell carcinoma or Stage 1 melanoma of the skin or in situ carcinoma of the
cervix are eligible).
- Patients with a malignancy that has been treated with surgery alone with curative
intent will also be excluded, unless the malignancy has been in documented remission
without treatment for ≥ 3 years prior to enrollment.
- Evidence of significant, uncontrolled concomitant diseases that could affect
compliance with the protocol or interpretation of results or that could increase risk
to the patient.
- Significant pulmonary disease (including obstructive pulmonary disease and history of
bronchospasm).
- Known active bacterial, viral, fungal, mycobacterial, parasitic, or other infection
(excluding fungal infections of nail beds) at study enrollment, or any major episode
of infection requiring treatment with IV antibiotics or hospitalization (relating to
the completion of the course of antibiotics) within 4 weeks prior to Cycle 1 Day 1.
- Requires the use of warfarin (because of potential drug-drug interactions that may
potentially increase the exposure of warfarin).
- Received the following agents within 7 days prior to the first dose of venetoclax:
- CYP3A inhibitors such as fluconazole, ketoconazole, and clarithromycin
- Strong CYP3A inducers such as rifampin, carbamazepine
- Consumed grapefruit, grapefruit products, Seville oranges (including marmalade
containing Seville oranges) or star fruit within 3 days prior to the first dose of
venetoclax.
- Clinically significant history of liver disease, including viral or other hepatitis,
current alcohol abuse, or cirrhosis.
- Presence of positive test results for Hepatitis B, Hepatitis C and CMV.
- Recent major surgery (within 6 weeks prior to the start of Cycle 1 Day 1), other than
for diagnosis.
- Any of the following abnormal laboratory values:
- Calculated creatinine clearance < 50 mL/min with the use of the 24-hour
creatinine clearance or modified Cockcroft-Gault equation
