Inclusion Criteria:

          1. Age ≥18 years at the screening visit.

          2. Patients with histologically or cytologically documented, confirmed diagnosis of
             advanced malignancy, whose disease failed to respond to or progressed after standard
             therapy or they could not tolerate standard therapy.

          3. Measurable or evaluable disease according to RECIST v1.1.

          4. ECOG performance status of 0 or 1.

          5. Predicted life expectancy ≥12 weeks.

          6. For men and women of child-bearing potential, willing to use adequate contraception
             (i.e., latex condom, cervical cap, diaphragm, abstinence, etc.) for the entire
             duration of the study.

        1. If female, must be either postmenopausal, sterilised or, if sexually active, effectively
        practicing an acceptable method of contraception (either oral, parenteral, or implantable
        hormonal contraceptives, intrauterine device or barrier and spermicide). Subjects must
        agree to use adequate contraception during the study and for at least 12 weeks (or longer
        as per local requirement) after the last dose of study treatment.

        2. Male subjects agree to ensure that they or their female partner(s) use adequate
        contraception during the study and for at least 12 weeks (or longer as per local
        requirement) after the subject receives their last dose of study treatment.

        Exclusion Criteria:

          1. Patients are not able to provide written informed consent to study participation

          2. Patients who have been treated with most recent radiotherapy, hormonal therapy,
             immunotherapy, chemotherapy or investigational drugs within ≤21 days or 5 half-lives
             (whichever is shorter) from enrolment (screening), and/or who have any unresolved NCI
             Common Terminology Criteria of Adverse Events (CTCAE) v4.03 > Grade 1
             treatment-related side effect (with the exception of alopecia).

          3. Patient has anemia due to HbS or HbC disease, alpha or beta thalassaemia

          4. Patient has Glucose-6-phosphate deficiency

          5. Patient has known or suspected history of cytochrome b5-MetHb-reductase pathway
             deficiency

          6. Persons of Navajo, Athabaska Alaskan or Siberian Yakutsk descent

          7. Patient has untreated severe hypothyroidism

          8. Patient has laboratory estimations indicating organ system dysfunction:

               1. Absolute neutrophil count (ANC) <1.5 X 109/L

               2. Platelets <100 X 109/L

               3. Hemoglobin <9g/dL

               4. Total bilirubin >1.5 mg/dL

               5. ALT and AST >3.0 times the ULN if no liver involvement or >5 times the ULN with
                  liver involvement.

               6. Calculated creatinine clearance <60mL/min estimated using the Cockcroft-Gault
                  equation:

                  • Cockcroft-Gault equation: creatinine clearance = (140 - age in years) x (wt in
                  kg)) x 1.23) / (serum creatinine in micromol/l) [For women multiply the result of
                  calculation by 0.85].

          9. Major surgery (excluding placement of vascular access) ≤21 days from beginning of the
             study drug or minor surgical procedures ≤7 days. No waiting is required following
             implantable port and catheter placement.

         10. Any of the following cardiac criteria:

               1. Congestive heart failure (CHF), grade III or IV per New York Heart Association
                  (NYHA) classification

               2. Symptomatic cardiomyopathy

               3. > Class II Cardiac ventricular arrhythmias requiring anti-arrhythmic therapy

               4. Unstable angina or new-onset angina

               5. QTcF interval >470 ms on screening ECG.

        9. Severe or uncontrolled systemic diseases including uncontrolled hypertension, active
        bleeding diatheses 10. Any evidence of active infection including active Hepatitis B,
        Hepatitis C or human immunodeficiency virus 11. The patient has concurrent severe and/or
        uncontrolled medical disease that could compromise participation in the study (i.e.,
        uncontrolled diabetes, severe infection requiring active treatment, severe malnutrition,
        chronic severe liver or renal disease, uncontrolled hypertension, active bleeding
        diatheses).

        12. Active infection requiring IV antibiotics within two weeks prior to treatment, or
        evidence of TB infection.

        13. Hepatitis B, Hepatitis C or human immunodeficiency virus 14. Previously untreated brain
        metastases. Patients who have received radiation or surgery for brain metastases are
        eligible if therapy was completed at least 3 weeks previously and there is no evidence of
        central nervous system disease progression, mild neurologic symptoms, and no requirement
        for chronic corticosteroid therapy.

        15. Lactating, breastfeeding, or positive pregnancy test for female patients of
        child-bearing potential.

        16. The patient is unable to swallow capsules and/or has a surgical or anatomical condition
        that precludes swallowing and absorbing oral medication on an ongoing basis (for oral
        therapy only).

        17. Patients with prior stem cell transplantation or solid organ transplantation.

        18. History of other malignancies (except for adequately treated basal or squamous cell
        carcinoma or carcinoma in situ) within the last 3 years.

        17. Any other condition that would, in the investigator's judgment, contraindicate the
        patient's participation in the clinical study due to safety concerns or compliance with
        clinical study procedures.