I. To determine if the addition of ribociclib (LEE011) to everolimus and letrozole improves
progression free survival in patients with advanced or recurrent endometrial carcinoma.
I. To determine clinical benefit and the median duration of progression-free survival (PFS)
and overall survival (OS) in patients with advanced or recurrent endometrial carcinoma
treated with ribociclib (LEE011), everolimus and letrozole versus everolimus and letrozole
II. To determine the frequency and severity of toxicities associated with ribociclib
(LEE011), everolimus (RAD001), and letrozole in this cohort of patients.
III. To determine the presence of a CTNNB1 mutation is associated with response to ribociclib
(LEE011), everolimus (RAD001), and letrozole.
IV. To determine if liquid biopsies at baseline and 8 weeks correlate with presence of a
tissue mutation or response to therapy.
I. To examine the pharmacokinetic and pharmacodynamic effects of ribociclib in patients with
advanced or recurrent endometrial carcinoma.
OUTLINE: Patients are randomized to 1 of 2 arms.
ARM I: Patients receive ribociclib orally (PO) once daily (QD), everolimus PO QD, and
letrozole PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease
progression or unacceptable toxicity.
ARM II: Patients receive everolimus PO QD and letrozole PO QD on days 1-28. Cycles repeat
every 28 days in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, participants are followed up at 30 days and then every 3
- Patient has signed the informed consent (ICF) prior to any screening procedures being
performed and is able to comply with protocol requirements.
- Patients must have histologically-confirmed endometrial carcinoma (endometrioid and
mixed endometrioid tumors, any grade).
- Patients must have advanced or recurrent disease that is refractory to curative
treatment based on imaging or clinical exam.
- Patient must consent to allow for a baseline tumor biopsy. Tumor material from
biopsies done before the screening period are acceptable if the biopsy was performed
within 3 months prior to the planned treatment start and no other systemic cancer
therapy was administered in the interim. If a biopsy is performed and the specimen is
considered non-diagnostic, does not have enough tissue, or the biopsy is deemed
infeasible to perform, this does not prevent the patient from proceeding with the
- Patients must have had no more than two prior chemotherapeutic regimens for recurrent
endometrial carcinoma. Chemotherapy administered in conjunction with primary radiation
as a radio-sensitizer is not counted as a prior treatment for recurrent or advanced
- Prior radiation therapy of any kind is allowed.
- Prior treatment with letrozole is allowed if the patient meets the washout period of
- All patients must have measurable disease per Response Evaluation Criteria in Solid
Tumors (RECIST) version 1.1 defined as at least one "target lesion" that can be
accurately measured in at least one dimension (>= 10 mm longest dimension to be
recorded; Lymph nodes must be >= 15 mm per short axis). Each lesion must be > 20 mm
when measured by palpation or conventional imaging techniques (computed tomography
[CT] or magnetic resonance imaging [MRI] - based on primary physician preference) or >
10 mm with spiral CT scan. Measurable lesions must be at least 2 times the slice
thickness in millimeters. Tumors within a previously irradiated field will be
designated as "non-target" lesions unless progression is documented. Ascites and
pleural effusions are not considered measurable disease. If the measurable disease is
confined to a solitary lesion, its neoplastic nature should be confirmed by
- Patients must not be pregnant, breastfeeding or of child-bearing potential. Patients
are considered not of child bearing potential if they are surgically sterile (they
have undergone a total hysterectomy, bilateral tubal ligation, or bilateral
oophorectomy) or they are postmenopausal for greater than 12 months (if patient is
uncertain of amenorrhea for 12 months, a pregnancy test will be done to confirm
pregnancy status). Patients in whom ovaries are present and were not previously
menopausal at the time of hysterectomy, should have a serum estradiol < 10 pm/mL to
confirm ovarian senescence.
- Patients must be off all other anti-tumor therapies (including immunologic agents) for
at least four weeks prior to study registration. Patients on hormonal agents require a
washout for 10 days.
- Gynecologic Oncology Group (GOG) performance status of 0 to 1.
- Absolute neutrophil count >= 1.5 x 10^9/L (at screening).
- Platelets >= 100 x 10^9/L (at screening).
- Hemoglobin >= 9.0 g/dL (at screening).
- International normalized ratio (INR) =< 1.5 (at screening).
- Serum creatinine =< 1.5 mg/dL or creatinine clearance >=50 mL/min (at screening).
- Estimated glomerular filtration rate (eGFR) >= 30mL/min/1.73m^2 (at screening)
according to the Modification of Diet in Renal Disease (MDRD) formula.
- In the absence of liver metastases, alanine aminotransferase (ALT) and aspartate
aminotransferase (AST) < 2.5 x upper limit of normal (ULN). If the patient has liver
metastases, ALT and AST < 5 x ULN (at screening).
- Total bilirubin < ULN; or total bilirubin =< 3.0 x ULN or direct bilirubin =< 1.5 x
ULN in patients with well-documented Gilbert's syndrome (at screening).
- Fasting serum cholesterol =< 240 mg/dL or =< 7.75 mmol/L and fasting triglycerides =<
2.5 x ULN (at screening).
- NOTE: In case one or both of these thresholds are exceeded, the patient can only
be included after initiation of appropriate lipid lowering medication.
- Patient with available standard 12-lead electrocardiography (ECG) with the following
parameters at screening: a. Corrected QT interval by Fridericia's formula (QTcF)
interval at screening < 450 msec (using Fridericia's correction). b. Resting heart
rate 50-100 beats per minute (bpm).
- Patients who have uterine sarcomas, carcinosarcomas, serous tumors (any component) or
pure clear cell carcinomas.
- Patients currently receiving anticancer therapies or who have received anticancer
therapies within 4 weeks of the start of study drug (including chemotherapy, radiation
therapy, antibody based therapy, etc.)
- Patient has not recovered from all toxicities related to prior anticancer therapies to
National Cancer Institute (NCI)-Common Terminology Criteria for Adverse Events (CTCAE)
version 4.03 grade =< 1 (exception to this criterion: patients with grade 1
taxane-induced neuropathy, any grade of alopecia, amenorrhea or other toxicities not
considered a safety risk for the patient as per investigator's discretion are allowed
to enter the study).
- Patient has had major surgery within 14 days prior to starting study drug or has not
recovered from major side effects (tumor biopsy is not considered as major surgery).
- Participation in other studies involving investigational drug(s) within 30 days prior
to randomization or within 5 half-lives of the investigational product (whichever is
longer) or participation in any other type of medical research judged not to be
scientifically or medically compatible with this study.
- Patients receiving chronic, systemic treatment with corticosteroids or another
immunosuppressive agent. Topical, short duration (< 5 days) of systemic
corticosteroids, eye drops, local injections, or inhaled corticosteroids are allowed.
- Patients should not receive immunization with attenuated live vaccines within one week
of study entry or during study period. Close contact with those who have received
attenuated live vaccines should be avoided during treatment with everolimus. Examples
of live vaccines include intranasal influenza, measles, mumps, rubella, oral polio,
bacillus Calmette-guerin (BCG), yellow fever, varicella and TY21a typhoid vaccines.
- Patients with central nervous system (CNS) involvement unless they meet all of the
- At least 4 weeks from prior therapy completion (including radiation and/or
surgery) to starting the study treatment.
- Clinically stable CNS tumor at the time of screening and not receiving steroids
and/or enzyme-inducing anti-epileptic medications for brain metastases.
- Patient has a concurrent malignancy or malignancy within 3 years prior to starting
study drug, with the exception of adequately treated, basal or squamous cell carcinoma
curatively resected cervical cancer in situ.
- Patient has any other concurrent severe and/or uncontrolled medical condition that
would, in the investigator's judgment, may cause unacceptable safety risks,
contraindicate patient participation in the clinical study or compromise compliance
with the protocol (e.g. chronic pancreatitis, chronic active hepatitis, active
untreated or uncontrolled fungal, bacterial or viral infections, etc.).
- Patient has a known history of human immunodeficiency virus (HIV) infection (testing
- Clinically significant, uncontrolled heart disease and/or cardiac repolarization
abnormalities, including any of the following:
- History of acute coronary syndromes (including myocardial infarction, unstable
angina, coronary artery bypass grafting, coronary angioplasty, or stenting) or
symptomatic pericarditis within 6 months prior to screening.
- History of documented congestive heart failure (New York Heart Association
functional classification III-IV).
- Documented cardiomyopathy.
- Left ventricular ejection fraction (LVEF) < 50% as determined by multiple gated
acquisition (MUGA) scan or echocardiogram (ECHO) at screening.
- Clinically significant cardiac arrhythmias (e.g. ventricular tachycardia),
complete left bundle branch block, high-grade AV block (e.g. bifascicular block,
Mobitz type II and third-degree AV block).
- Long QT syndrome or family history of idiopathic sudden death or congenital long
QT syndrome, or any of the following:
- Risk factors for Torsades de Pointe (TdP) including uncorrected
hypocalcemia, hypokalemia or hypomagnesemia, history of cardiac failure, or
history of clinically significant/symptomatic bradycardia.
- Concomitant use of medication(s) with a known risk to prolong the QT
interval and/or known to cause Torsades de Pointe that cannot be
discontinued (within 5 half-lives or 7 days prior to starting study drug) or
replaced by safe alternative medication.
- Inability to determine the QT interval on screening (QTcF, using
- Systolic blood pressure (SBP) > 160 mmHg or < 90 mmHg at screening.
- Impairment of gastrointestinal function or gastrointestinal disease that may
significantly alter the absorption of study medication (e.g., ulcerative disease,
uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome or small bowel
resection associated with malabsorption).
- Patient is currently receiving any of the following medications and cannot be
discontinued 7 days prior to starting study drug:
- Known strong inducers or inhibitors of CYP3A4/5, including grapefruit, grapefruit
hybrids, pummelos, star-fruit, and Seville oranges.
- That have a narrow therapeutic window and are predominantly metabolized through
- Herbal preparations/medications, dietary supplements.
- Hormone replacement therapy, topical estrogens (including any intra-vaginal
preparations), megestrol acetate and selective estrogen-receptor modulators (e.g.
- Patient is currently receiving warfarin or other coumarin-derived anticoagulant for
treatment, prophylaxis or otherwise. Therapy with heparin, low molecular weight
heparin (LMWH) or fondaparinux is allowed.
- Liver disease such as cirrhosis or severe hepatic impairment (patient with a
Child-Pugh score B or C).
- Note: A detailed assessment of hepatitis B/C medical history and risk factors
must be done at screening for all patients. Hepatitis B virus (HBV)
deoxyribonucleic acid (DNA) and hepatitis C virus (HCV) ribonucleic acid (RNA)
polymerase chain reaction (PCR) testing are required at screening for all
patients with a positive medical history based on risk factors and/or
confirmation of prior HBV/HCV infection.
- Patients who have received prior treatment with an mTOR inhibitor (e.g., sirolimus,
- Patients with a known hypersensitivity to ribociclib or everolimus or to its
- History of noncompliance to medical regimens.
- Patients unwilling to or unable to comply with the protocol.